Results 121 to 130 of about 677,076 (187)

Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin‐specific quality specification

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7606-7613, October 2026.
Abstract BACKGROUND Geographic origin influences the phytochemical composition and biological activities of medicinal plant resources. Xanthium strumarium L. (XS) fruit is widely used in East Asian traditional medicine. However, current pharmacopeial standards primarily recognize Chinese‐derived material, despite the availability and traditional use of
Eunsu Song, Seung‐Min Oh, Jiyeon Chun, Jinah Hwang   +3 more
wiley   +1 more source

2‑Hydroxypyridine‑N‑oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors

, 2016
With the aim to develop effective and selective human tyrosinase inhibitors, we investigated aurone derivatives whose B-ring was replaced by a non-oxidizable 2-hydroxypyridine-N-oxide (HOPNO) moiety.
Luigi Bubacco (83582), Elina Buitrago (1705141), Marcello Carotti (3356324), Renaud Hardré (1705120), Ahcène Boumendjel (1705126), Aurélie Gouron (1514860), Elisabetta Bergantino (83579), Hélène Jamet (1705123), Marius Réglier (1293408), Romain Haudecoeur (2002357), Marc Maresca (377182), Catherine Belle (1705135)   +11 more
core   +1 more source

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts

ChemistryOpen, Volume 15, Issue 10, October 2026.
S. heldreichiana and S. tomentosa can be considered as effective sources of natural bioactive agents for further in vivo pharmacological evaluation and development. The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses.
Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay   +9 more
wiley   +1 more source

Chlorine Position Governs the Multitarget Bioactivity of Phenylhydrazines: In Vitro Antioxidant, Anti‐Inflammatory, Anti‐Tyrosinase and Antibacterial Evaluation Supported by DFT and Molecular Docking

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
Positional chlorination emerges as a key determinant of multitarget activity in phenylhydrazines. The para‐chloro derivative H3 shows the strongest anti‐inflammatory response, notable antibacterial activity, favorable ADMET behavior, and high COX‐2 affinity. DFT descriptors and molecular docking rationalize these substitution‐dependent effects, linking
L. Aouachria, S. Issadi, H. Debab, I. Selatnia, A.G. Soliman, K. Metwally, O. M. A. Khamaysa, Han‐seung Lee, Hassane Lgaz   +8 more
wiley   +1 more source

Synthesis of Methylisoxazol‐5(4H)‐One Derivatives Using an ʟ‐Proline‐Functionalized‐MMT Catalyst: Molecular Docking and Cancer Cell Line Cytotoxicity Studies

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
An efficient and sustainable method for the synthesis of biologically relevant isoxazoles is developed using modified montmorillonite‐K10 (MMT) nanoclay as a heterogeneous catalyst. The catalyst exhibited good stability and reusability over five cycles, with minimal loss of activity (95%–88%). ABSTRACT Guided by green chemistry principles, an efficient
Anushka Servesh, Santhosh Govindaraju, Sumaiya Tabassum, Sankar Ganesh Ramaraj   +3 more
wiley   +1 more source

Plant‐Derived Senolytic Ingredient, Camellia sinensis Root Extract, Ameliorates Skin Aging‐Associated Phenotypes

Experimental Dermatology, Volume 35, Issue 10, October 2026.
Camellia sinensis root extract (SENOMUNE) preferentially reduced senescent dermal fibroblast viability and decreased SASP‐associated factor expression and secretion. Its effects were associated with features consistent with LMP/cathepsin/AIF‐associated caspase‐independent cell death.
Sunyoung Park, Siyoung Cho, Daejin Min, Hyunjung Choi, Kyeonghwan Hwang, In Sup Kil, Won‐Seok Park, Hyoung‐June Kim   +7 more
wiley   +1 more source

Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin

International Journal of Cosmetic Science, Volume 48, Issue 5, Page 1006-1017, October 2026.
Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang, Hong Zhang, Chengming Zhang, Wencai Jiang, Luonan Chen, Yimei Tan, Ying Zou, Xuelan Gu   +7 more
wiley   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, Volume 65, Issue 10, Page 2038-2048, October 2026.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Clinical Efficacy and Mechanisms of ZiyuShuang, an Anti‐Skin Aging Formula Identified Through Network Medicine Framework Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin aging, a key aspect of physiological decline, markedly affects appearance, making strategies to delay it vital for quality of life. Materials and Methods We applied network medicine analysis to screen herbal medicines from the TCMSP database, yielding an anti‐skin aging formula, ZiYuShuang (ZYS).
Yingpeng Tong, Xiangmei Ni, Xinnan Jiang, Ru Zhang, Pengcheng Guo, Chunbo Feng, Jianxin Wang   +6 more
wiley   +1 more source

Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity

, 2015
Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effective approach to control hyperpigmentation in human skin and enzymatic browning in fruits and vegetables ...
Saeed Emami, Seyedeh Mahdieh Hashemi
core