Results 71 to 80 of about 16,390 (163)
Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.A promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Francesca Rizzo +5 more
wiley +1 more source
Frontiers in Microbiology, 2020 Hydrogen can serve as an electron donor for chemolithotrophic acidophiles, especially in the deep terrestrial subsurface and geothermal ecosystems. Nevertheless, the current knowledge of hydrogen utilization by mesophilic acidophiles is minimal.
Jiri Kucera +8 more
doaj +1 more source
Nanophotonics, Volume 15, Issue 20, 27 October 2026.Mitochondrial oxidative metabolism generates ROS. Downstream chemiexcitation triplet carbonyls, singlet oxygen; produces ultra‐weak photon emission (UPE). Energetic bounds restrict well‐coupled respiration to extremely weak, red/NIR‐biased emission. Stronger visible UPE indicates elevated oxidative flux, linking measured photon counts to redox state ...
Samuel Crowther +2 more
wiley +1 more source
, 2018 The cardioprotective effect of ubiquinol on the model of myocardium reperfusion injury in rats was investigated. The study was carried out using mature males of outbred rats. Myocardial ischemia-reperfusion injury was performed after 30-minute ligation
V.G. Makarov +4 more
core +1 more source
Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise [PDF]
, 2020 Strenuous exercise (any activity that expends six metabolic equivalents per minute or more causing sensations of fatigue and exhaustion to occur, inducing deleterious effects, affecting negatively different cells), induces muscle damage and ...
Luis Javier Chirosa +11 more
core +1 more source
Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock [PDF]
, 2013 Hemorrhagic shock (HS) and fluid resuscitation triggers ischemia-reperfusion injury in cells and increases the production of reactive oxygen species (ROS) which are known to activate the intrinsic pathway of apoptosis and contribute to organ dysfunction ...
Bennetts, Paul S.
core +1 more source
Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to chemotherapy that cannot be fully explained by mutational drivers alone. This review examines how lipid metabolic reprogramming contributes to cytotoxic chemotherapy resistance in PDAC and evaluates whether lipidomics and flux‐resolved metabolic analyses can identify ...
Revathi Valliyodu +11 more
wiley +1 more source
, 2000 To assess the effect of chronic ethanol ingestion in the content of the reduced forms of coenzymes Q(9) (ubiquinol-9) and Q(10) (ubiquinol-10) as a factor contributing to oxidative stress in liver and brain, male Wistar rats were fed ad libitum a basal ...
Carrasquedo, F. +8 more
core +1 more source
Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress
Регуляторные исследования и экспертиза лекарственных средств, 2019 The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants.
O. A. Goroshko +3 more
doaj +1 more source
Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions
LifeCoenzyme CoQ10 (CoQ10) is an endogenous lipid-soluble antioxidant that effectively protects lipids, proteins, and DNA from oxidation due to its ability to undergo redox transitions between oxidized and reduced forms.
Elena I. Kalenikova +3 more
doaj +1 more source