Results 41 to 50 of about 9,904 (211)
Saudi Pharmaceutical Journal, 2017 Glucuronidation is an important phase II pathway responsible for many endogenous substances and drug metabolism. The present work evaluated allele frequencies of certain UDP-glucuronosyl-transferases (UGT 1A6∗2, A7∗12, A8∗3, A9∗3, 2B7∗2, and 2B15∗2) in ...
Khalid M. Alkharfy +8 more
doaj +1 more source
Drug Testing and Analysis, EarlyView.EtG hair analysis has a standard method for detecting alcohol abuse. In this study, we assessed the long‐term stability of EtG in hair stored up to 10 years. A total of 909 samples originally analyzed between 2013 and 2022 were re‐tested in 2023 by LC‐MS/MS.
Sara Casati +6 more
wiley +1 more source
Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase) from Streptomyces griseochromogenes, the first prokaryotic UDP-glucuronosyltransferase [PDF]
Journal of Bacteriology, 1994 Cytosylglucuronic acid synthase (cytosine: UDP-glucuronosyltransferase), the first prokaryotic UDP-GT and a key enzyme in the biosynthesis of the antibiotic blasticidin S, was purified 870-fold. It has optimum activity at a pH of 8.4 to 8.6, Kms of 6.0 (UDP-glucuronic acid) and 243 (cytosine) microM, and a maximum rate of metabolism of 14.6 mumol/min ...
Steven J. Gould, Jincan Guo
openaire +3 more sources
Pest Management Science, EarlyView.Assembly of Ctenoplusia agnata genome at the chromosomal level and the use of pest management through comparative genomes with Plusiinae pests. Abstract BACKGROUND Ctenoplusia agnata is a polyphagous pest affecting bean crops and cruciferous vegetables across East Asian countries, including Korea.
Juil Kim +2 more
wiley +1 more source
The clinical application of
Human Genomics, 2010 Over the past decade, the number of pharmacogenetic tests has increased considerably, allowing for the development of our knowledge of their clinical application.
Marques Sara, Ikediobi Ogechi N
doaj +1 more source
Cancer Science, EarlyView.The limited efficacy of current immune checkpoint inhibitors requires new approaches to overcome immunosuppression. In this phase 1 study, ONO‐4578 plus nivolumab showed a manageable safety profile, signs of antitumor activity, and immune activation, providing reference for further studies evaluating the clinical benefit of ONO‐4578 and nivolumab in ...
Akihito Kawazoe +24 more
wiley +1 more source
Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids
Xenobiotica, 2020 Herbs are often administered in combination with therapeutic drugs, raising the possibility for herb–drug interactions (HDIs). Furoquinoline alkaloids are found in Rutaceae plants, which are structurally similar and have many medicinal properties. This study aims to investigate the inhibition of four furoquinoline alkaloids on the activity of UDP ...
Ce Wang +8 more
openaire +3 more sources
Cancer Medicine, 2023 Background Chromosomal heterogeneity leads to the abnormal expression and mutation of tumor‐specific genes. Drugs targeting oncogenes have been extensively developed.
Haidong Wu +9 more
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Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis
Cell Proliferation, EarlyView.Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu +7 more
wiley +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste +4 more
wiley +1 more source