Results 11 to 20 of about 2,950 (153)

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction [PDF]

Beilstein Journal of Organic Chemistry, 2016
Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good ...
Samantha Caputo, Andrea Basso, Lisa Moni, Renata Riva, Valeria Rocca, Luca Banfi   +5 more
doaj   +2 more sources

Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines [PDF]

Beilstein Journal of Organic Chemistry
A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5-a][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions.
Muhammad Hasan, Anatoly A. Peshkov, Syed Anis Ali Shah, Andrey Belyaev, Chang-Keun Lim, Shunyi Wang, Vsevolod A. Peshkov   +6 more
doaj   +2 more sources

Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations

ChemistryOpen, 2023
The Ugi reaction, a multicomponent reaction, allows diversity‐oriented synthesis Its importance is recognized by an exponential increase in the publications utilizing the post‐Ugi transformations as a strategy to build complex molecules via simple and ...
Rinkal B. Bhoraniya, Dr. Sachin G. Modha
doaj   +1 more source

Catalytic Three‐Component Ugi Reaction [PDF]

Angewandte Chemie International Edition, 2008
Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α‐amino acid derivatives and in diversity‐oriented
Pan, S., List, B.
openaire   +3 more sources

Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid. [PDF]

J Pept Sci
Novel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Bhowal KB, Hitti R, Lubell WD.
europepmc   +2 more sources

Strain and Complexity, Passerini and Ugi Reactions of Four‐Membered Heterocycles and Further Elaboration of TOSMIC Product

ChemistryOpen, 2023
Straightforward and general Passerini and Ugi procedures have been developed to incorporate four‐membered heterocycles into highly functionalized scaffolds.
Gábor Sztanó, Dr. Zoltán Dobi, Dr. Tibor Soós   +2 more
doaj   +1 more source

Controlling the stereochemistry in 2-oxo-aldehyde-derived Ugi adducts through the cinchona alkaloid-promoted electrophilic fluorination

Beilstein Journal of Organic Chemistry, 2020
In this report, we introduce a new strategy for controlling the stereochemistry in Ugi adducts. Instead of controlling stereochemistry directly during the Ugi reaction we have attempted to stereodefine the chiral center at the peptidyl position through ...
Yuqing Wang, Gaigai Wang, Anatoly A. Peshkov, Ruwei Yao, Muhammad Hasan, Manzoor Zaman, Chao Liu, Stepan Kashtanov, Olga P. Pereshivko, Vsevolod A. Peshkov   +9 more
doaj   +1 more source

NMR-Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza-Diels-Alder Cycloadditions. [PDF]

Magn Reson Chem
We report the results from a kinetic and mechanistic investigation of an inverse‐electron‐demand Diels–Alder (IEDDA) cycloaddition involving an oxazole‐type diene synthesized via an Ugi–Zhu multicomponent reaction (UZ‐3CR). ABSTRACT Pyridines are a crucial class of heterocycles with widespread applications in natural products, pharmaceuticals, and ...
Suárez-Moreno GV, Méndez F, Gutierrez-Carrillo A, Rincón-Guevara MA, Amador-Sánchez YA, Islas-Jácome A, González-Zamora E.   +6 more
europepmc   +2 more sources

Regioselective Cyclic Iminium Formation of Ugi Advanced Intermediates: Rapid Access to 3,4-Dihydropyrazin-2(1H)-ones and Other Diverse Nitrogen-Containing Heterocycles

Molecules, 2023
Herein, advanced intermediates were synthesized through Ugi four-component reactions of isocyanides, aldehydes, masked amino aldehyde, and carboxylic acids, including N-protected amino acids.
Naděžda Cankařová, Viktor Krchňák
doaj   +1 more source

Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction

SynOpen, 2023
Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range
Yana Sakhno, Oleksandr Radchenko, Vyacheslav Saraev, Yuliia Shliapkina, Mariia Kaidash, Mariia Shyshkina, Svitlana Shishkina, Vladimir Musatov, Sergey Desenko, Valentyn Chebanov   +9 more
doaj   +1 more source