Results 21 to 30 of about 11,747 (233)
Catalytic Three‐Component Ugi Reaction [PDF]
Angewandte Chemie International Edition, 2008 Perfect atom economy characterizes a novel catalytic three‐component Ugi reaction (see example). Different α‐amino amides are formed in good yields from aldehydes, primary amines, and isocyanides in the presence of phenyl phosphinic acid as the catalyst. The products will be useful for the synthesis of α‐amino acid derivatives and in diversity‐oriented
Pan, S., List, B.
openaire +3 more sources
Two-Step Macrocycle Synthesis by Classical Ugi Reaction. [PDF]
J Org Chem, 2018 The direct nonpeptidic macrocycle synthesis of α-isocyano-ω-amines via the classical Ugi four-component reaction (U-4CR) is introduced. Herein an efficient and flexible two-step procedure to complex macrocycles is reported. In the first step, the reaction between unprotected diamines and isocyanocarboxylic acids gives high diversity of unprecedented ...
Abdelraheem EMM +5 more
europepmc +5 more sources
ChemistryOpen, 2023 Straightforward and general Passerini and Ugi procedures have been developed to incorporate four‐membered heterocycles into highly functionalized scaffolds.
Gábor Sztanó +2 more
doaj +1 more source
From Ugi Multicomponent Reaction to Linkers for Bioconjugation [PDF]
ACS Omega, 2020 Bioconjugation is a key approach for the development of novel molecular entities with clinical applications. The biocompatibility and specificity of biomolecules such as peptides, proteins, and antibodies make these macromolecules ideal carriers for selective targeted therapies. In this context, there is a need to develop new molecular units that cover
Iván Ramos-Tomillero +8 more
doaj +5 more sources
Open Notebook Science Challenge: Solubilities of Organic Compounds in Organic Solvents [PDF]
, 2010 This book contains the results of the Open Notebook Science Solubility Challenge. All experimental measurements are provided with a link to either the laboratory notebook page where the experiment was carried out or to a literature reference.
Andrew Lang +17 more
core +6 more sources
N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides. [PDF]
Org Lett, 2017 The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields.
Chandgude AL, Dömling A.
europepmc +4 more sources
Beilstein Journal of Organic Chemistry, 2020 In this report, we introduce a new strategy for controlling the stereochemistry in Ugi adducts. Instead of controlling stereochemistry directly during the Ugi reaction we have attempted to stereodefine the chiral center at the peptidyl position through ...
Yuqing Wang +9 more
doaj +1 more source
Molecules, 2023 Herein, advanced intermediates were synthesized through Ugi four-component reactions of isocyanides, aldehydes, masked amino aldehyde, and carboxylic acids, including N-protected amino acids.
Naděžda Cankařová, Viktor Krchňák
doaj +1 more source
Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction
SynOpen, 2023 Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range
Yana Sakhno +9 more
doaj +1 more source
Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]
, 2018 Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S. +12 more
core +1 more source