Results 111 to 120 of about 24,862 (198)
PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles
Molecules, 2020 A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication.
Alžběta Dostálková +8 more
doaj +1 more source
Cell Reports, 2017 Although microtubule motors mediate intracellular virus transport, the underlying interactions and control mechanisms remain poorly defined. This is particularly true for HIV-1 cores, which undergo complex, interconnected processes of cytosolic transport,
Viacheslav Malikov, Mojgan H. Naghavi
doaj +1 more source
Analysis of the impact of TRIM5 polymorphism on retroviral replication [PDF]
This project aims to improve the SIV/rhesus macaques animal model for AIDS. TRIM5α is an antiviral molecule expressed in mammals including rhesus macaques.
Maplanka, Charlotte
core
Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]
, 2013 Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P. +12 more
core +2 more sources
Single-domain antibodies and their formatting to combat viral infections [PDF]
, 2018 Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies +4 more
core +2 more sources
Infectivity and Uncoating of Adenovirus Cores
Intervirology, 1980 A temperature-sensitive mutant of adenovirus type 2 grown at 39 degrees (tsl-39 degrees) produces noninfectious physical particles. DNA and core structures derived from such virion particles, however, were found to be infectious at the permissive temperature.
A, Mirza, J, Weber
openaire +2 more sources
eLife, 2014 Mutations in the inositol 5-phosphatase OCRL cause Lowe syndrome and Dent's disease. Although OCRL, a direct clathrin interactor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been primarily attributed to intracellular ...
Ramiro Nández +9 more
doaj +1 more source
, 2013 The goal of a virus particle is to transport its genome in a replication-competent form from an infected cell to an uninfected cell. To enter a new host cell, the majority of viruses take advantage of the endocytic mechanisms of the cell and wait until ...
Helenius, Ari, Yamauchi, Yohei
core +4 more sources
TNOA Journal of Ophthalmic Science and Research, 2022 Smital Mahadeorao Metange +1 more
openaire +2 more sources
Mechanisms of Entry and Endosomal Pathway of African Swine Fever Virus
Vaccines, 2017 African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and presently spreading in Russia and neighboring countries, including Poland and recently, the Czech Republic.
Elena G. Sánchez +2 more
doaj +1 more source