Results 231 to 240 of about 102,674 (250)

Dysfunctional states of unconventional T-cell subsets in cancer

Journal of Leukocyte Biology, 2023
Abstract Unconventional T cells represent a promising therapeutic agent to overcome the current limitations of immunotherapies due to their universal T-cell receptors, ability to respond directly to cytokine stimulation, and capacity to recruit and modulate conventional immune cells in the tumor microenvironment.
Elizabeth N, Katsnelson, Andrea, Spengler, Joanne, Domenico, Kasey L, Couts, Liyen, Loh, Laurent, Gapin, Martin D, McCarter, Richard P, Tobin   +7 more
openaire   +2 more sources

Phenotypical and Functional Characterization of Cytotoxic Unconventional T-Cells

2021
During the last two decades, the immunology field has been focused on the study of conventional T-cells, leading to important advances in identification of specific subsets involved in promoting and suppressing immune response in patients with cancer, autoimmune disease or transplanted patients.
Gigante M., Ranieri E.
openaire   +3 more sources

Mucosal-associated invariant T cells: unconventional development and function

Trends in Immunology, 2011
Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major histocompatibility complex related molecule, MR1. Here, we review recent knowledge of this T cell population.
Lionel, Le Bourhis, Lucia, Guerri, Mathilde, Dusseaux, Emmanuel, Martin, Claire, Soudais, Olivier, Lantz   +5 more
openaire   +2 more sources

Significance of Unconventional Peripheral CD4+CD8dim T Cell Subsets

Journal of Clinical Immunology, 2005
Routine T cells phenotyping occasionally reveals a CD4+CD8dim T cell subset with an apparently homogeneous dot plot. The aim of this study was to elucidate their immunological significance from analysis of 31 healthy donors, 21 elderly and 220 immune deficient patients.
Claude, Lambert, Lambert, Claude, Mohammad, Ibrahim, Ibrahim, Mohammad, Cristina, Iobagiu, Iobagiu, Cristina, Christian, Genin, Genin, Christian   +7 more
openaire   +2 more sources

Unconventional or Preset αβ T Cells: Evolutionarily Conserved Tissue-Resident T Cells Recognizing Nonpeptidic Ligands

Annual Review of Cell and Developmental Biology, 2017
A majority of T cells bearing the αβ T cell receptor (TCR) are specific for peptides bound to polymorphic classical major histocompatibility complex (MHC) molecules. Smaller subsets of T cells are reactive toward various nonpeptidic ligands associated with nonpolymorphic MHC class-Ib (MHC-Ib) molecules.
Legoux, Francois, Salou, Marion, Lantz, Olivier   +2 more
openaire   +2 more sources

Landscape of unconventional γδ T cell subsets in cancer

Molecular Biology Reports
T cells are broadly categorized into two groups, namely conventional and unconventional T cells. Conventional T cells are the most prevalent and well-studied subset of T cells. On the other hand, unconventional T cells exhibit diverse functions shared between innate and adaptive immune cells.
Parviz, Azimnasab-Sorkhabi, Maryam, Soltani-Asl, Mohammad, Soleiman Ekhtiyari, Jose Roberto, Kfoury Junior   +3 more
openaire   +2 more sources

Activation and Function of Unconventional T Cells

2018
Efferent innate immune responses include the function of unconventional T cells with partial innate properties. While most studies of T lymphocytes have focused on T cells involved in adaptive immune responses by reacting to complexes of peptide and major histocompatibility complex proteins, many other types of T cells do not match this paradigm.
openaire   +1 more source

Breaking the mold: Unconventional T cells in cancer therapy

Cancer Cell
Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME).
Yan-Ruide, Li, Kuangyi, Zhou, Yichen, Zhu, Tyler, Halladay, Lili, Yang   +4 more
openaire   +2 more sources

Unconventional T Cells Influence Clinical Outcome After Allogeneic Hematopoietic Cell Transplantation

Journal of Clinical Immunology
We evaluated the impact of early recovery of mucosal-associated invariant T cells (MAIT) and gamma-delta (γδ) T cells, especially Vδ2+ T cells, on the clinical outcomes of 76 patients who underwent allogeneic hematopoietic cell transplantation (allo-HCT).
Lama, Siblany, Nicolas, Stocker, Laure, Ricard, Eolia, Brissot, Rémy, Duléry, Anne, Banet, Simona, Sestili, Ramdane, Belhocine, Zoé, Van de Wyngaert, Agnès, Bonnin, Antoine, Capes, Tounes, Ledraa, Pauline, Beurier, Karen, Fadel, Mohamad, Mohty, Béatrice, Gaugler, Florent, Malard   +16 more
openaire   +2 more sources

Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis

Digestive Diseases and Sciences, 2018
Ignacio, Catalan-Serra, Juan Carlos, Andreu-Ballester, Torunn, Bruland, Arne Kristian, Sandvik   +3 more
openaire   +2 more sources