Results 91 to 100 of about 2,782,099 (278)

Gut microecology: effective targets for natural products to modulate uric acid metabolism

Frontiers in Pharmacology
Gut microecology,the complex community consisting of microorganisms and their microenvironments in the gastrointestinal tract, plays a vital role in maintaining overall health and regulating various physiological and pathological processes.
Hui Wang, Yixuan Zheng, Mengfan Yang, Lu Wang, Yao Xu, Siqi You, Nan Mao, Nan Mao, Junming Fan, Junming Fan, Sichong Ren, Sichong Ren, Sichong Ren   +12 more
doaj   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

Drug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi, M. Y. Al‐Jaber, M. Al‐Nesf, W. Samsam, Abdulaziz Farooq, N. M. Thomas, M. Stuart, N. Robinson, G. Zangenfeind, D. Rovira, N. Mohamed‐Ali, A. Beotra, V. Mohamed‐Ali, M. Al‐Maadheed   +13 more
wiley   +1 more source

Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers. [PDF]

Int J Mol Sci, 2022
Lin Z, Jayachandran M, Haskic Z, Kumar S, Lieske JC.   +4 more
europepmc   +1 more source

Uric Acid and Arterial Stiffness

, 2020
Adriana Albu,1 Ioana Para,2 Mihai Porojan1 12nd Department of Internal Medicine; 24th Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCorrespondence: Ioana Para 4th Department of ...
Porojan M, Albu A, Para I
core  

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

A heterozygous variant in the SLC22A12 gene in a Sri Lanka family associated with mild renal hypouricemia

BMC Pediatrics, 2018
Background Renal hypouricemia is a rare heterogeneous inherited disorder characterized by impaired tubular uric acid transport, reabsorption insufficiency and /or acceleration of secretion.
Dinesha Maduri Vidanapathirana, Subashinie Jayasena, Eresha Jasinge, Blanka Stiburkova   +3 more
doaj   +1 more source

Corrigendum: The Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling Pathway. [PDF]

Front Pharmacol, 2021
Wu YL, Chen JF, Jiang LY, Wu XL, Liu YH, Gao CJ, Wu Y, Yi XQ, Su ZR, Cai J, Chen JN.   +10 more
europepmc   +1 more source

Is Uric Acid a Marker in Obstructive Sleep Apnea Syndrome?

, 2016
Objective Uric acid which arises in conditions such as cardiovascular diseases, Chronic kidney failure, metabolic syndrome is a strong and independent marker of morbidity and mortality.
Elif Torun Parmaksız, Ergün Parmaksız, Sevda Cömert, Gülten Aktın Güngör, Banu Salepçi, Gülten Aktin Güngör   +5 more
core   +1 more source