Results 81 to 90 of about 2,782,099 (278)

Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3 [PDF]

, 2004
Amino acids are regarded as the nitrogen ‘currency’ of plants. Amino acids can be taken up from the soil directly or synthesized from inorganic nitrogen, and then circulated in the plant via phloem and xylem.
Sakiko Okumoto, Leister, D., Frommer, Wolf B., Wolf B. Frommer, Okumoto, Sakiko, FISCHER, Wolf N, Stierhof, York Dieter, Stierhof, Y., Fischer, W., Wolfgang Koch, Koch, W., FROMMER, Wolf B, Mechthild Tegeder, Fischer, Wolf N., Leister, Dario, Wolf N. Fischer, Koch, Wolfgang, Okumoto, S., Tegeder, Mechthild, Dario Leister, Tegeder, M., Biehl, A., York Dieter Stierhof, Alexander Biehl, Biehl, Alexander, Frommer, W.   +25 more
core   +2 more sources

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu, I. A. Anjola, L. O. Fasasi, D. P. Fadipe, A. T. Afuye, F. O. Fasanya, O. E. Oke   +6 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Apple polyphenols alleviate hyperuricemia by inhibiting xanthine oxidase and promoting uric acid excretion

Journal of Functional Foods
Hyperuricemia, a metabolic disorder caused by excessive uric acid accumulation, is a major risk factor for gout and related kidney damage. Current pharmacological treatments often have side effects, emphasizing the need for safer alternatives. This study
Ying Chen, Shuhui Hu, Yanjun Guo, Yan Wang, Lei Chen, Xin He, Yajie Yu, Andong Ji, Shengjie Pei, Kelei Li, Xiaofei Guo, Duo Li   +11 more
doaj   +1 more source

The Effect of Uric Acid Levels on Bone Metabolism in Postmenopausal Women [PDF]

, 2019
Objective:The decrease in estrogen levels leads to oxidative stress by accumulating reactive oxygen species in the cell and suppressing the antioxidant defense system. Thus, the activity of osteoclasts and bone resorption are stimulated.
Mustafa Şahin, Sevgi Atar, Okan Dikker
core   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice

Frontiers in Pharmacology, 2019
Background:Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia. The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria.
Ruixia Bao, Mengyang Liu, Dan Wang, Shaoshi Wen, Haiyang Yu, Yi Zhong, Zheng Li, Yi Zhang, Tao Wang   +8 more
doaj   +1 more source

Developing Potent Human Uric Acid Transporter 1 (hURAT1) Inhibitors

, 2011
The kidneys are a vital organ in the human body. They serve several purposes including homeostatic functions such as regulating extracellular fluid volume and maintaining acid-base and electrolyte balance and are essential regarding the excretion of ...
Michael F. Wempe, Quade, Bettina, Iwen, Timothy J., Ian R. Ross, Hitoshi Endou, Rice, Peter J., Bettina Quade, Frick, Morin M., Timothy J. Iwen, Promsuk Jutabha, Jutabha, Promsuk, Ross, Ian R., Peter J. Rice, Naohiko Anzai, Anzai, Naohiko, Endou, Hitoshi, Wempe, Michael F., Morin M. Frick   +17 more
core   +1 more source

Identification of a plausible serum uric acid cut-off value as prognostic marker of stroke: the Uric Acid Right for Heart Health (URRAH) study

, 2022
The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting combined (fatal and non-fatal ...
Borghi C, Pontremoli R, Ferri C, Nazzaro P, Barbagallo CM, Salvetti M, Rivasi G, Quarti-Trevano F, Masi S, Bombelli M, D'elia L, Casiglia E, Desideri G, Muiesan ML, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)., Maloberti A, Galletti F, Verdecchia P, Cirillo P, Virdis A, Ungar A, Rattazzi M, Tocci G, Cirillo M, Giannattasio C, Tikhonoff V, Gesualdo L, Viazzi F, Spinella P, Palatini P, Parati G, Cicero AFG, Mallamaci F, Grassi G, Mazza A, Volpe M, Iaccarino G   +36 more
core   +1 more source

Systematic review of clinical trials and cohort studies evaluating HIV post‐exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquisition, PEP completion, adverse events (AEs) leading to discontinuation and/
Stanley O. Onyegbule, Maryam Habib, Rija Khalid, Jessie Tu, Deborah Yoong, Jaris Swidrovich, Wale Ajiboye, Patrick O'Byrne, Ameeta E. Singh, Jean‐Guy Baril, Tatiana Sotindjo, Mark W. Hull, Darrell H. S. Tan   +12 more
wiley   +1 more source