A Patient With CAD Deficiency Responsive to Uridine and Literature Review
Frontiers in Neurology, 2020 CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis, and pyrimidine can be alternatively recycled from uridine. Trio whole-exome sequencing identified CAD compound heterozygous mutations in a new male patient with global ...
Ling Zhou +3 more
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Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases
Frontiers in PhysiologyUridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with a concentration higher than the other nucleosides. As a simple metabolite, uridine plays a pivotal role in various biological processes. In addition to nucleic acid synthesis,
Yueyuan Yang +3 more
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Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease [PDF]
Frontiers in ImmunologyIntroductionInflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology.
Caiyi Yuan +10 more
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Scientific Reports, 2021 The effect of uridine on the myocardial ischemic and reperfusion injury was investigated. A possible mechanism of its cardioprotective action was established.
Irina B. Krylova +7 more
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Studies on uridine-diphosphate-glucose [PDF]
Biochemical Journal, 1952 Blanco y ...
Antonella Paladini, Luis F. Leloir
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Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model [PDF]
Future Science OAAims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais +6 more
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Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice. [PDF]
PLoS ONE, 2016 Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress. Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced liver lipid accumulation.
Yasuyo Urasaki +2 more
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Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis. [PDF]
PLoS ONE, 2015 Uridine has earlier been show to down modulate inflammation in models of lung inflammation. The aim of this study was to evaluate the anti-inflammatory effect of uridine in arthritis.Arthritis was induced by intra-articular injection of mBSA in the knee ...
Sudeep Chenna Narendra +3 more
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Indispensable residue for uridine binding in the uridine-cytidine kinase family
Biochemistry and Biophysics Reports, 2017 Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine.
Fumiaki Tomoike +5 more
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Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
Scientific Reports, 2017 Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator of inflammation. However, very little is known about its effect on intestinal inflammation.
Manish Kumar Jeengar +4 more
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