Results 1 to 10 of about 99,858 (332)

A Patient With CAD Deficiency Responsive to Uridine and Literature Review

Frontiers in Neurology, 2020
CAD encodes a multifunctional enzyme involved in de novo pyrimidine biosynthesis, and pyrimidine can be alternatively recycled from uridine. Trio whole-exome sequencing identified CAD compound heterozygous mutations in a new male patient with global ...
Ling Zhou, Han Xu, Tianshuang Wang, Ye Wu   +3 more
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Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease [PDF]

Frontiers in Immunology
IntroductionInflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology.
Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai   +10 more
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Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model [PDF]

Future Science OA
Aims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais, Muna Barakat, Rabaa Y. Athamneh, Mohammad A. A. Al-Najjar, Lujain F. Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah   +6 more
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Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. [PDF]

PLoS ONE, 2010
BackgroundUridine has been advocated for the treatment of HIV-1/HAART-associated lipodystrophy (HALS), although its metabolism in HIV-1-infected patients is poorly understood.MethodsPlasma uridine concentrations were measured in 35 controls and 221 HIV-1-
Pere Domingo, Javier Torres-Torronteras, Virginia Pomar, Marta Giralt, Joan Carles Domingo, Maria Del Mar Gutierrez, José M Gallego-Escuredo, Maria Gracia Mateo, Pedro Cano-Soldado, Irene Fernandez, Marçal Pastor-Anglada, Francesc Vidal, Francesc Villarroya, Antoni Andreu, Ramon Marti   +14 more
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A Treatable Genetic Disease Caused by CAD Mutation

Frontiers in Pediatrics, 2022
Type 50 early infantile epileptic encephalopathy, or EIEE-50 for short, is an autosomal recessive genetic disorder resulting from CAD mutations. So far, little has been reported on the disease.
Xia Peng, Li-ping Xia, Hai-ju Zhang, Jing Zhang, Shi-qian Yu, Shun Wang, Yu-ming Xu, Baozhen Yao, Jingping Ye   +8 more
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LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
INTRODUCTION We examined associations between nutritional biomarkers and clinical progression in individuals with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD)‐type dementia.
Francisca A. deLeeuw, Betty M. Tijms, Astrid S. Doorduijn, Heleen M. A. Hendriksen, Ondine van deRest, Marian A. E. devan der Schueren, Marjolein Visser, Ellen G. H. M. vanden Heuvel, Nick vanWijk, Jörgen Bierau, Bart N. vanBerckel, Philip Scheltens, Maartje I. Kester, Wiesje M. van derFlier, Charlotte E. Teunissen   +14 more
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SYNTHESIS A NUMBER OF URIDINE DERIVATIVES AND STUDYING THEIR BIOLOGICAL ACTIVITY ON PATHOGENIC BACTERIA. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
یتضمن البحث تحضیر سلسلة من المرکبات بطریقة ازدواج املاح الدیازونیوم مع الیوردین. وتم التأکد من الصیغ الترکیبیة للمرکبات المحضرة بدراسة اطیاف الاشعة فوق البنفسجیة (U.V) واطیاف الاشعة تحت الحمراء(I.R) والتحلیل الدقیق لعناصر الکاربون، الهیدروجین والنتروجین (
YOUSIF HINDY KHALAF, SALMAN ALI AHMED
doaj   +1 more source

Lactobacillus plantarum Ameliorates High-Carbohydrate Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress by Upregulating Uridine Synthesis

Antioxidants, 2022
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear.
Rong Xu, Tong Wang, Fei-Fei Ding, Nan-Nan Zhou, Fang Qiao, Li-Qiao Chen, Zhen-Yu Du, Mei-Ling Zhang   +7 more
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Development of Diversified Methods for Chemical Modification of the 5,6-Double Bond of Uracil Derivatives Depending on Active Methylene Compounds

Molecules, 2012
The reaction of 5-halogenouracil and uridine derivatives <strong>1</strong> and <strong>7</strong> with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the ...
Kosaku Hirota, Hideo Inoue, Yoshinari Sawama, Yoshifumi Maki, Yasunari Monguchi, Yukio Kitade, Kanoko Ikawa, Yusuke Iida, Hironao Sajiki   +8 more
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Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells

Frontiers in Nutrition, 2022
BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang, Yilin Liu, Yilin Liu, Tiantian Zhou, Lumin Gao, Jianxi Li, Xin Wu, Xin Wu, Yu-long Yin, Yu-long Yin   +9 more
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