Uridine treatment protects against blood–brain barrier disruption in a rat model of Li-pilocarpine-induced status epilepticus [PDF]
Frontiers in NeuroscienceIntroductionBlood–brain barrier (BBB) disruption is one of the most striking changes triggered by status epilepticus, which deserves specific attention in terms of novel treatment approaches targeting epileptogenesis.
Birnur Aydin +6 more
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The Role of Uridine in Health and Disease [PDF]
Journal of Inflammation ResearchCongkuan Song,1– 3 Zhen-Juan Liu,4 Bangjun Xu,5 Rui Zou,1,2 Weidong Hu1– 3 1Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Hubei Provincial Clinical Research Center for Cancer, Wuhan, People’s ...
Song C, Liu ZJ, Xu B, Zou R, Hu W
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Uridine Prevents Negative Effects of OXPHOS Xenobiotics on Dopaminergic Neuronal Differentiation [PDF]
Cells, 2019 Neuronal differentiation appears to be dependent on oxidative phosphorylation capacity. Several drugs inhibit oxidative phosphorylation and might be detrimental for neuronal differentiation.
Eldris Iglesias +8 more
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Dietary uridine improves lipid homeostasis in high-fat diet-induced obese mice by regulating liver gene expression and metabolomic profiles [PDF]
Frontiers in NutritionIntroductionObesity is caused by excessive storage of adipose tissue and leads to metabolic disorders. Uridine exerts modulatory effects on lipid metabolism, but the regulatory mechanism in obesity needs further research.MethodsIn this study, the effects
Yilin Liu +4 more
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Differences in the Effectiveness of Uridine and Liriope platyphylla L. Between Complement Component 3 Deficiency- and Loperamide-Induced Constipation May Be Associated with the Alternative Regulation of the Cyclic Adenosine Monophosphate Downstream Signaling Pathway [PDF]
PharmaceuticalsBackground/Objectives: Constipation can be induced in animal models through various factors such as loperamide (Lop) or complement component 3 (C3) deficiency.
Hee Jin Song +11 more
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A novel combination therapy with Uridine and Praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation. [PDF]
PLoS PathogensSchistosomiasis-induced hepatic fibrosis, a consequence of egg-induced granulomatous lesions, remains untreated by current drugs. Therefore, the development of novel antifibrosis drugs is of paramount importance.
Xiangyu Zhou +10 more
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Indispensable residue for uridine binding in the uridine-cytidine kinase family
Biochemistry and Biophysics Reports, 2017 Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine.
Fumiaki Tomoike +5 more
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Antioxidants, 2022 The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear.
Rong Xu +7 more
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Hospital Pharmacy, 2016 Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing
Cada, Dennis J +3 more
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A Treatable Genetic Disease Caused by CAD Mutation
Frontiers in Pediatrics, 2022 Type 50 early infantile epileptic encephalopathy, or EIEE-50 for short, is an autosomal recessive genetic disorder resulting from CAD mutations. So far, little has been reported on the disease.
Xia Peng +8 more
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