Results 161 to 170 of about 99,858 (332)

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Uridine Diphosphate Glucose Dehydrogenase

, 1963
Nelson D. Goldberg, June L. Dahl, Robert E. Parks   +2 more
openalex   +1 more source

THE ENZYMIC INTERCONVERSION OF URIDINE DIPHOSPHOGALACTOSE AND URIDINE DIPHOSPHOGLUCOSE

Journal of Biological Chemistry, 1957
openaire   +3 more sources

Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite

The Journal of Clinical Pharmacology, EarlyView.
Abstract To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double‐blind, randomized, placebo‐controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge test after administering placebo, DEX, or DOR.
Saeed Rezaee, Caroline E. Wright, Alyn H. Morice, Amin Rostami‐Hodjegan   +3 more
wiley   +1 more source

Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway. [PDF]

Sci Rep
Ding C, Zuo R, Liao Q, Guo Z, He J, Ye Z, Liu G.   +6 more
europepmc   +1 more source

The Synthesis of Type III Pneumococcal Capsular Polysaccharide from Uridine Nucleotides by a Cell-free Extract of Diplococcus pneumoniae Type III

, 1960
Evelyn E.B. Smith, George T. Mills, Harriet P. Bernheimer, Robert Austrian   +3 more
openalex   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Uridine, a Therapeutic Nucleoside, Exacerbates Alcoholic Liver Disease via SRC Kinase Activation: A Network Toxicology and Molecular Dynamics Perspective. [PDF]

Int J Mol Sci
Liu Z, Wang Z, Wang J, Xu S, Zhang T.
europepmc   +1 more source

Adenosine Triphosphate: Uridine Monophosphate-Cytidine Monophosphate Phosphotransferase from Tetrahymena pyriformis

, 1969
B. Winfred Ruffner, Elizabeth P. Anderson   +1 more
openalex   +1 more source

An adipo-biliary-uridine axis that regulates energy homeostasis

Science, 2017
Yingfeng Deng, Zhao V. Wang, R. Gordillo, Yu A. An, Chen Zhang, Qiren Liang, J. Yoshino, K. Cautivo, J. D. De Brabander, J. Elmquist, J. Horton, Joseph A. Hill, S. Klein, P. Scherer   +13 more
semanticscholar   +1 more source