Results 161 to 170 of about 73,683 (226)

Age‐ and sex‐associated variability in lamotrigine prescription patterns and clearance

Epilepsia, Volume 67, Issue 3, Page 1256-1266, March 2026.
Abstract Objective Lamotrigine is one of the most widely prescribed antiseizure medication (ASM) and mood stabilizer in the United States due to its favorable side‐effect profile, lower risk of teratogenicity, and minimal drug–drug interactions.
Charul Avachat, Yuhan Long, Ashley Petersen, Angela K. Birnbaum, Sima I. Patel   +4 more
wiley   +1 more source

Discovery of α-glucosidase inhibitors from Paenibacillus sp. JNUCC 31 via genome mining, fatty acid profiling, and in silico analysis. [PDF]

Sci Rep
Xu Y, Liang X, Hyun CG.
europepmc   +1 more source

Structural analysis of the NifL‐NifA complex reveals the molecular basis of anti‐activation of nitrogen fixation gene expression in Azotobacter vinelandii

The FEBS Journal, Volume 293, Issue 6, Page 1643-1663, March 2026.
Understanding the molecular basis of nitrogen fixation is essential for engineering bacteria that fulfill the nitrogen demand of crop plants, reducing our reliance on synthetic nitrogen fertilizers. The bacterial two‐component system comprising the anti‐activator protein (NifL) and the Nif‐specific transcriptional activator (NifA) controls the nitrogen
Marcelo Bueno Batista, Jake Richardson, Michael W. Webster, Dmitry Ghilarov, John W. Peters, David M. Lawson, Ray Dixon   +6 more
wiley   +1 more source

From Amphiphiles to mRNA platforms: emerging vaccination strategies for pancreatic cancer. [PDF]

Exp Hematol Oncol
Lee DG, Noh K.
europepmc   +1 more source

Sex‐Specific Factors Influencing HIV Infection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley   +1 more source

Synthesis of 4'-C-α-Aminoethoxy-2'-O-Methyl-5-Methyl- and 5-Propynyl-Uridine Phosphoramidites for Structurally Optimized Antisense Oligonucleotides. [PDF]

Curr Protoc
Mahmoud EM, Ueno Y.
europepmc   +1 more source

Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 423-430, March 2026.
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang, Zhiqin Fang, Lam C. Tsoi, Johann E. Gudjonsson   +3 more
wiley   +1 more source

Potentiometric and spectroscopic characterization of uridine and its derivatives complexes. [PDF]

Sci Rep
Stachowiak K, Zabiszak M, Teubert A, Jastrząb R.   +3 more
europepmc   +1 more source

Uridine as a hub in cancer metabolism and RNA biology. [PDF]

Exp Mol Med
Choi KM, Berard BA, Yoon JH, Kim D.
europepmc   +1 more source

Reduced Versus Oxidized NAD+ Precursors Drive Distinct Transcriptomic, Proteomic, and Metabolic Profiles in Hepatocytes

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Comparative transcriptomic, proteomic, and metabolomic analyses of reduced (NRH, NMNH) versus oxidized (NR, NMN) NAD+ precursors reveal that NRH and NMNH induce broader and more potent transcriptomic, proteomic, and metabolomic changes. Although all precursors increase NAD+ pathway metabolites, reduced precursors uniquely elicit a pseudo‐stress ...
Kasper T. Vinten, Bauke V. Schomakers, Simone Denis, Michel van Weeghel, Aldo Jongejan, Rob Ofman, Sander R. Piersma, Connie R. Jimenez, Georges E. Janssens, Rubén Zapata‐Pérez, Riekelt H. Houtkooper   +10 more
wiley   +1 more source