Results 31 to 40 of about 99,858 (332)

URIDINE DIPHOSPHATE ACETYLGLUCOSAMINE [PDF]

Journal of Biological Chemistry, 1953
Blanco y ...
Cabib, Enrico, Leloir, Luis Federico, Cardini, Carlos E.   +2 more
openaire   +3 more sources

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

bioRxiv, 2020
SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic domain belonging to the EndoU family that is highly conserved in coronaviruses.
Youngchang Kim, J. Wower, N. Maltseva, Changsoo Chang, R. Jedrzejczak, M. Wilamowski, Soowon Kang, V. Nicolaescu, G. Randall, K. Michalska, A. Joachimiak   +10 more
semanticscholar   +1 more source

Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis

BioMed Research International, 2020
Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives contribute to reduction of cytotoxicity and suppression of drug ...
Yumei Zhang, Songge Guo, C. Xie, Jun Fang   +3 more
semanticscholar   +1 more source

In vitro antimicrobial, physicochemical, pharmacokinetics and molecular docking studies of benzoyl uridine esters against SARS-CoV-2 main protease

Journal of Biomolecular Structure and Dynamics, 2020
Different esters were found potential against microorganisms, and could be a better choice to solve the multidrug resistant (MDR) pathogenic global issue due to their improved biological and pharmacokinetic properties.
M. Matin, M. Uzzaman, S. A. Chowdhury, M. H. Bhuiyan   +3 more
semanticscholar   +1 more source

Identification of Major Antioxidant Compounds from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake)

Frontiers in Bioscience-Elite, 2022
Basidiomycetes-X, of which Japanese vernacular name is Echigoshirayukidake, is a local speciality mushroom found and cultivated in Japan that has been distributed as a precious cuisine material or as a functional food with medicinal properties ...
Toshio Sakamoto, Zhenshi Li, Ayaka Nishida, Asako Kadokawa, Takayuki Yoshida, Naoki Wada, Seiichi Matsugo, Yutaka Nakamura, Shinji Sato, Tetsuya Konishi   +9 more
doaj   +1 more source

Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy

Genetics in Medicine, 2020
Pathogenic autosomal recessive variants in CAD, encoding the multienzymatic protein initiating pyrimidine de novo biosynthesis, cause a severe inborn metabolic disorder treatable with a dietary supplement of uridine.
F. del Caño-Ochoa, B. Ng, M. Abedalthagafi, M. Almannai, R. Cohn, Gregory Costain, O. Elpeleg, H. Houlden, E. G. Karimiani, Pengfei Liu, M. C. Manzini, R. Maroofian, M. Muriello, Ali Al-Otaibi, Hema Patel, Edvardson Shimon, V. Sutton, M. B. Toosi, L. Wolfe, J. Rosenfeld, H. Freeze, S. Ramón-Maiques   +21 more
semanticscholar   +1 more source

Anti-Hepatitis C Virus Activity of Uridine Derivatives of 2-Deoxy Sugars

Molecules, 2018
Hepatitis C virus (HCV), the etiological agent of the most common and dangerous diseases of the liver, is a major health problem worldwide. Despite many attempts, there is still no vaccine available.
Ewelina Krol, Ilona Wandzik, Gabriela Pastuch-Gawolek, Boguslaw Szewczyk   +3 more
doaj   +1 more source

Honey as Source of Nitrogen Compounds: Aromatic Amino Acids, Free Nucleosides and Their Derivatives

Molecules, 2020
The content of selected major nitrogen compounds including nucleosides and their derivatives was evaluated in 75 samples of seven varieties of honey (heather, buckwheat, black locust, goldenrod, canola, fir, linden) by targeted ultra-high performance ...
Piotr M. Kuś
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules, 2019
Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk   +5 more
doaj   +1 more source