Uridine release during aminopyridine-induced epilepsy
Neurobiology of Disease, 2004 Uridine, like adenosine, is released under sustained depolarization and it can inhibit hippocampal neuronal activity, suggesting that uridine may be released during seizures and can be involved in epileptic mechanisms.In an in vivo microdialysis study ...
A Slézia +8 more
doaj +1 more source
Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells
Frontiers in Nutrition, 2022 BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang +9 more
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Acta physiologica latino americana, 1950 6 páginas en ...
Cardini, Carlos E. +3 more
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Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics
Molbank, 2020 Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents.
Kristin Leyerer +2 more
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Depletion of mitochondria in mammalian cells through enforced mitophagy [PDF]
, 2016 Mitochondria are not only the 'powerhouse' of the cell; they are also involved in a multitude of processes that include calcium storage, the cell cycle and cell death.
Correia-Melo, Clara +3 more
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Molecules, 2013 New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik +5 more
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Case Report: Rapid Treatment of Uridine-Responsive Epileptic Encephalopathy Caused by CAD Deficiency
Frontiers in Pharmacology, 2020 We present two unrelated Chinese patients with CAD deficiency manifesting with a triad of infantile-onset psychomotor developmental delay with regression, drug-refractory epilepsy, and anaemia with anisopoikilocytosis.
Ling Zhou +10 more
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Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
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Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus
Molecules, 2019 Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol +5 more
doaj +1 more source
Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids [PDF]
, 2010 : BACKGROUND AND OBJECTIVE: With prolonged use of anabolic androgenic steroids (AAS), occasional incidents of renal disorders have been observed. Independently, it has also been established that there are considerable inter-individual and inter-ethnic ...
Barker, James +5 more
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