Results 31 to 40 of about 98,911 (236)

Development of Diversified Methods for Chemical Modification of the 5,6-Double Bond of Uracil Derivatives Depending on Active Methylene Compounds

Molecules, 2012
The reaction of 5-halogenouracil and uridine derivatives <strong>1</strong> and <strong>7</strong> with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the ...
Kosaku Hirota, Hideo Inoue, Yoshinari Sawama, Yoshifumi Maki, Yasunari Monguchi, Yukio Kitade, Kanoko Ikawa, Yusuke Iida, Hironao Sajiki   +8 more
doaj   +1 more source

In vitro antimicrobial, physicochemical, pharmacokinetics and molecular docking studies of benzoyl uridine esters against SARS-CoV-2 main protease

Journal of Biomolecular Structure and Dynamics, 2020
Different esters were found potential against microorganisms, and could be a better choice to solve the multidrug resistant (MDR) pathogenic global issue due to their improved biological and pharmacokinetic properties.
M. Matin, M. Uzzaman, S. A. Chowdhury, M. H. Bhuiyan   +3 more
semanticscholar   +1 more source

Uridine affects amino acid metabolism in sow-piglets model and increases viability of pTr2 cells

Frontiers in Nutrition, 2022
BackgroundAs an important nucleoside precursor in salvage synthesis pathway of uridine monophosphate, uridine (UR) is the most abundant nucleotide in sow milk.
Hong-ling Wang, Yilin Liu, Yilin Liu, Tiantian Zhou, Lumin Gao, Jianxi Li, Xin Wu, Xin Wu, Yu-long Yin, Yu-long Yin   +9 more
doaj   +1 more source

Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy

Genetics in Medicine, 2020
Pathogenic autosomal recessive variants in CAD, encoding the multienzymatic protein initiating pyrimidine de novo biosynthesis, cause a severe inborn metabolic disorder treatable with a dietary supplement of uridine.
F. del Caño-Ochoa, B. Ng, M. Abedalthagafi, M. Almannai, R. Cohn, Gregory Costain, O. Elpeleg, H. Houlden, E. G. Karimiani, Pengfei Liu, M. C. Manzini, R. Maroofian, M. Muriello, Ali Al-Otaibi, Hema Patel, Edvardson Shimon, V. Sutton, M. B. Toosi, L. Wolfe, J. Rosenfeld, H. Freeze, S. Ramón-Maiques   +21 more
semanticscholar   +1 more source

Silicate-, Magnesium Ion-, and Urea-Induced Prebiotic Phosphorylation of Uridine via Pyrophosphate; Revisiting the Hot Drying Water Pool Scenario

Life, 2020
The availability of nucleotides on the early Earth is of great significance for the origin of a self-replicating system capable of undergoing evolution. We hereby report the successful phosphorylation reactions of the nucleoside uridine under heating in ...
Maheen Gull, Arthur Omran, Tian-Cheng Feng, M. Pasek   +3 more
semanticscholar   +1 more source

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules, 2019
Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system.
Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk   +5 more
doaj   +1 more source

An Open-label Randomized Crossover Study with Adaptive Design of the Pharmacokinetics and Bioequivalence of GP30121 and Ceraxon® Corrected for Endogenous Analyte Level

Разработка и регистрация лекарственных средств, 2023
Introduction. Citicoline is an endogenous nucleoside consisting of cytidine and choline linked by a diphosphate bridge that is involved in the synthesis of membrane phospholipids.
A. N. Arevefa, A. R. Dorotenko, S. M. Noskov, I. E. Makarenko, R. V. Drai, T. N. Komarov, O. A. Archakova, N. S. Bagaeva, I. E. Shokhin   +8 more
doaj   +1 more source

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Molecules, 2013
New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik, Wiesław Szeja, Urszula Nawrot, Tadeusz Bieg, Katarzyna Kral, Jadwiga Paszkowska   +5 more
doaj   +1 more source

Anti-Hepatitis C Virus Activity of Uridine Derivatives of 2-Deoxy Sugars

Molecules, 2018
Hepatitis C virus (HCV), the etiological agent of the most common and dangerous diseases of the liver, is a major health problem worldwide. Despite many attempts, there is still no vaccine available.
Ewelina Krol, Ilona Wandzik, Gabriela Pastuch-Gawolek, Boguslaw Szewczyk   +3 more
doaj   +1 more source

Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics

Molbank, 2020
Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents.
Kristin Leyerer, Stefan Koppermann, Christian Ducho   +2 more
doaj   +1 more source