Results 61 to 70 of about 11,858 (187)

Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase

mBio
Multidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public health.
Larissa Dirr, Sven Cleeves, Isabel Ramón Roth, Linghui Li, Timm Fiebig, Thomas Ve, Susanne Häussler, Armin Braun, Mark von Itzstein, Jana I. Führing   +9 more
doaj   +1 more source

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source

Metabolomic Insights Into the Impact of a Maternal Western‐Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Plasma metabolites in adult offspring reflecting metabolic programming during critical developmental windows. ABSTRACT Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood ...
Catalina A. Pomar, Rocío A. Martin‐Chamorro, Petr Zouhar, Pedro Castillo, Tomas Cajka, Jan Kopecky, Andreu Palou, Mariona Palou, Catalina Picó   +8 more
wiley   +1 more source

Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
O‐GlcNAcylation serves as a nutrient and stress sensor that dynamically regulates autophagy at multiple stages in cancer cells. It fine‐tunes autophagy initiation, maturation and fusion by modifying key proteins such as ULK1, ATG4B and SNAP‐29. Context‐dependent O‐GlcNAcylation promotes tumour adaptation and therapy resistance via autophagy remodelling.
Yizhan Li, Ling Gao, Shaoming Li, Jingjing Zheng, Keqian Zhi, Wenhao Ren   +5 more
wiley   +1 more source

Biological Activities, Health Benefits and Synthesis of Equol and Its Derivatives: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Biological activities, health benefits and structures of equol and its derivatives. ABSTRACT Equol is a metabolite transformed from daidzein by intestinal microorganisms and has received extensive attention due to its various pharmacological activities and therapeutic potential.
Jiao‐Jiao Zhuo, Bing‐Juan Li, Meng‐Ran Tian   +2 more
wiley   +1 more source

Association Between Adiposity and Low Total Serum Bilirubin Concentration: A Retrospective, Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Bilirubin, an antioxidant and anti‐inflammatory agent, has been shown to negatively correlate with adiposity. However, the extent to which adiposity level influences total bilirubin (TBili) concentration remains unclear. We sought to evaluate the associations of body mass index (BMI; kg/m²) and waist circumference (WC) with
Trishna Parikh, Fariha Hameed, Sumaiya Islam, Shivani Reddy, Eshani Goradia, Bhargav Vemulapalli, Aayush Visaria   +6 more
wiley   +1 more source

CDG due to Defective Membrane Transporters: Update

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Congenital disorders of glycosylation are genetic defects in the glycoprotein and glycolipid glycan assembly and attachment. Some 200 CDG have been reported since the first clinical description in 1980. Most CDG are enzymatic deficiencies, but 13 (6.5%) are defects in the ER, Golgi apparatus (GA), and plasma membrane transporters.
D. Quelhas, C. R. Ferreira, J. Jaeken
wiley   +1 more source

Energy Metabolism Under Stress: Late‐Stage Leigh Syndrome Reveals Profound Cardiometabolic Perturbations in Ndufs4 KO Mice

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
Cardiac bioenergetic and metabolic perturbations in late‐stage Leigh syndrome. Whole‐body NDUFS4 loss severely impairs cardiac complex I activity and respiration, shifting reliance to complex II and reducing glycolytic, TCA, and amino acid‐derived energy‐generating substrates in the heart.
Karin Terburgh, Nastassja Sweeney, Roan Louw   +2 more
wiley   +1 more source

CRISPR/Cas9-Based Functional Characterization of SfUGT50A15 Reveals Its Roles in the Resistance of Spodoptera frugiperda to Chlorantraniliprole, Emamectin Benzoate, and Benzoxazinoids

Insects
UDP-glycosyltransferases (UGTs) are a diverse superfamily of enzymes. Insects utilize uridine diphosphate-glucose (UDP-glucose) as a glycosyl donor for glycosylation in vivo, involved in the glycosylation of lipophilic endosymbionts and xenobiotics ...
Zhan Shi, Mei Luo, Jinxi Yuan, Bin Gao, Minghuan Yang, Guirong Wang   +5 more
doaj   +1 more source

Advanced Tissue Imprinting With Pneumatic Press for Mass Spectrometry Imaging of Plant Tissues

Journal of Mass Spectrometry, Volume 61, Issue 1, January 2026.
ABSTRACT Sample preparation is an important first step to obtain high quality mass spectrometry imaging (MSI) data. Preparing plant tissues is especially challenging for MSI of thin tissues along the lateral dimensions. The unique challenges involved with plant tissues, such as fragile cell walls, hydrophobic barriers, and specific tissue structures ...
Pubudu Nuwan Perera Hapuarachchige, Vy T. Tat, Young Jin Lee   +2 more
wiley   +1 more source