Results 1 to 10 of about 25,610 (245)

Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor [PDF]

Frontiers in Pharmacology, 2022
Acute pulmonary embolism (APE) is a debilitating condition with high incidence and mortality rates. APE is widely treated with the serine protease urokinase or urokinase-type plasminogen activator (uPA) that functions by resolving blood clots via ...
Ran Zhu, Ting-Wei Liu, Fan Liu
doaj   +4 more sources

Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Plaur) and Its Molecular Target Mef2d [PDF]

Frontiers in Molecular Neuroscience, 2022
Urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored receptor of urokinase (uPA), which is involved in brain development, nerve regeneration, wound healing and tissue remodeling. We have recently shown that Plaur, which encodes uPAR,
Karina D. Rysenkova, Karina D. Rysenkova, Konstantin E. Troyanovskiy, Polina S. Klimovich, Polina S. Klimovich, Taisiya R. Bulyakova, Ekaterina M. Shelomentseva, Anna A. Shmakova, Anna A. Shmakova, Daria Yu. Tanygina, Olga I. Ivashkina, Olga I. Ivashkina, Olga I. Ivashkina, Konstantin V. Anokhin, Konstantin V. Anokhin, Maxim N. Karagyaur, Maria I. Zvereva, Kseniya A. Rubina, Vsevolod A. Tkachuk, Vsevolod A. Tkachuk, Ekaterina V. Semina, Ekaterina V. Semina   +21 more
doaj   +2 more sources

Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View [PDF]

Frontiers in Cell and Developmental Biology, 2022
Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum ...
Daniela Alfano, Paola Franco, Maria Patrizia Stoppelli   +2 more
doaj   +2 more sources

TLR4 Response to LPS Is Reinforced by Urokinase Receptor [PDF]

Frontiers in Immunology, 2020
GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood.
Yulia Kiyan, Sergey Tkachuk, Song Rong, Anna Gorrasi, Pia Ragno, Inna Dumler, Hermann Haller, Nelli Shushakova, Nelli Shushakova   +8 more
doaj   +2 more sources

Data on the inhibition of cell proliferation and invasion by the D2A-Ala peptide derived from the urokinase receptor [PDF]

Data in Brief, 2019
The data presented in this article are connected to our research article entitled “D2A-Ala peptide derived from the urokinase receptor exerts anti-tumoural effects in vitro and in vivo” (Furlan et al., 2018).
Federico Furlan, Gabriele Eden, Marco Archinti, Ralitsa Arnaudova, Giuseppina Andreotti, Valentina Citro, Maria Vittoria Cubellis, Andrea Motta, Bernard Degryse   +8 more
doaj   +2 more sources

Soluble Urokinase Receptor and Acute Kidney Injury. [PDF]

N Engl J Med, 2020
Acute kidney injury is common, with a major effect on morbidity and health care utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein thought to be involved in the pathogenesis of kidney disease. We investigated whether a high level of suPAR predisposed patients to acute kidney injury in multiple clinical ...
Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS, Holliday MW, Januzzi JL, Weisbord SD, Quyyumi AA, Reiser J.   +20 more
europepmc   +7 more sources

Soluble urokinase receptor is a kidney-specific vasoconstrictorResearch in context [PDF]

EBioMedicine
Summary: Background: Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune system-derived risk factor for acute and chronic kidney diseases.
Sebastian Buhl Rasmussen, Rasmus Bo Lindhardt, Georgina Gyarmati, Kirsten Madsen, Claus Bistrup, Lars Lund, Sisse Rye Ostrowski, Changli Wei, Janos Peti-Peterdi, Per Svenningsen, Jochen Reiser, Hanne Berg Ravn   +11 more
doaj   +2 more sources

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR [PDF]

Data in Brief, 2017
The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and ...
Bernard Degryse, Mishan Britto, Chun Xu Shan, Robert G. Wallace, Keith D. Rochfort, Philip M. Cummins, Gerardene Meade, Ronan P. Murphy   +7 more
doaj   +2 more sources

Let-7 Family microRNAs Regulate the Expression of the Urokinase-Receptor in Acute Myeloid Leukemia Cells [PDF]

Cells
The urokinase-receptor (uPAR) exerts multiple functions supporting most cancer hallmarks. Increased uPAR expression is associated with an unfavorable prognosis in several cancer types, including hematologic malignancies. We previously reported that three
Anna Li Santi, Mariaevelina Alfieri, Luigia Meo, Pia Ragno   +3 more
doaj   +2 more sources

Urokinase Receptor and Resistance to Targeted Anticancer Agents [PDF]

Frontiers in Pharmacology, 2015
The urokinase receptor/uPAR is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell.
Steven L. Gonias, Jingjing eHu
doaj   +2 more sources