Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View [PDF]
Frontiers in Cell and Developmental Biology, 2022 Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum ...
Daniela Alfano +2 more
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Urokinase Receptor and Resistance to Targeted Anticancer Agents [PDF]
Frontiers in Pharmacology, 2015 The urokinase receptor/uPAR is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell.
Steven L. Gonias, Jingjing eHu
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Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus [PDF]
Journal of Diabetes Research, 2017 Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. DN typically manifests by glomerular hyperfiltration and microalbuminuria; then, the disease progresses to impaired glomerular filtration rate, which leads to ...
Ranadheer R. Dande +3 more
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The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities. [PDF]
Cancers (Basel), 2021 Simple Summary Discovered more than three decades ago, the urokinase-type plasminogen activator receptor (uPAR) has now firmly established itself as a versatile molecular target holding promise for the treatment of aggressive malignancies.
Metrangolo V, Ploug M, Engelholm LH.
europepmc +2 more sources
Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor [PDF]
Frontiers in Pharmacology, 2022 Acute pulmonary embolism (APE) is a debilitating condition with high incidence and mortality rates. APE is widely treated with the serine protease urokinase or urokinase-type plasminogen activator (uPA) that functions by resolving blood clots via ...
Ran Zhu, Ting-Wei Liu, Fan Liu
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The Urokinase Receptor: A Multifunctional Receptor in Cancer Cell Biology. Therapeutic Implications. [PDF]
Int J Mol Sci, 2021 Proteolysis is a key event in several biological processes; proteolysis must be tightly controlled because its improper activation leads to dramatic consequences.
Li Santi A +3 more
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Soluble Urokinase Receptor and Acute Kidney Injury. [PDF]
N Engl J Med, 2020 BACKGROUND Acute kidney injury is common, with a major effect on morbidity and health care utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein thought to be involved in the pathogenesis of kidney disease.
Hayek SS +20 more
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Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Plaur) and Its Molecular Target Mef2d [PDF]
Frontiers in Molecular Neuroscience, 2022 Urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored receptor of urokinase (uPA), which is involved in brain development, nerve regeneration, wound healing and tissue remodeling. We have recently shown that Plaur, which encodes uPAR,
Karina D. Rysenkova +21 more
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Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI.
J Am Soc Nephrol, 2020 BACKGROUND AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, and coagulation, and soluble ...
Azam TU +27 more
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TLR4 Response to LPS Is Reinforced by Urokinase Receptor [PDF]
Frontiers in Immunology, 2020 GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood.
Yulia Kiyan +8 more
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