Results 21 to 30 of about 2,335,681 (277)

Urokinase-type plasminogen activator receptor as a predictive marker for cardiac disease among type 2 diabetic patients

Medical Journal of Babylon, 2023
Background: Type 2 diabetes mellitus is a progressive and chronic disease manifested by β-cell dysfunction and improved insulin resistance. Higher levels of urokinase-type plasminogen activator receptors have been found to predict morbidity and mortality
Melak Saleh Mohammed, Hind Shakir Ahmed
doaj   +1 more source

Immune Activation Mediates the Association of Advanced Hepatic Fibrosis With Adverse Outcomes in Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Literature suggests a bidirectional association between advanced hepatic fibrosis (AHF) and coronary artery disease (CAD). We evaluated the association of AHF with immune activation, systemic inflammation, and adverse outcomes in patients with
Vardhmaan Jain, Anurag Mehta, Terence B. Lee, Chang Liu, Nicholas W. S. Chew, Yi‐An Ko, Matthew E. Gold, Daniel A. Gold, Nishant Vatsa, Shivang R. Desai, Jonathan H. Kim, Alireza Rahbar, Yazan Haroun, Kiran Ejaz, Salim S. Hayek, Mohammad S. Siddiqui, Fadi N. Salloum, Laurence S. Sperling, Arun J. Sanyal, Arshed A. Quyyumi   +19 more
doaj   +1 more source

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Nature Medicine, 2021
Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to respiratory failure.
E. Kyriazopoulou, G. Poulakou, H. Milionis, S. Metallidis, G. Adamis, K. Tsiakos, A. Fragkou, A. Rapti, Christina Damoulari, M. Fantoni, I. Kalomenidis, G. Chrysos, A. Angheben, I. Kainis, Z. Alexiou, F. Castelli, F. Serino, M. Tsilika, P. Bakakos, E. Nicastri, V. Tzavara, E. Kostis, L. Dagna, Panagiotis Koufargyris, K. Dimakou, S. Savvanis, G. Tzatzagou, M. Chini, G. Cavalli, M. Bassetti, K. Katrini, V. Kotsis, G. Tsoukalas, C. Selmi, I. Bliziotis, M. Samarkos, M. Doumas, S. Ktena, A. Masgala, I. Papanikolaou, M. Kosmidou, D. Myrodia, A. Argyraki, C. Cardellino, K. Koliakou, E. Katsigianni, V. Rapti, E. Giannitsioti, A. Cingolani, S. Micha, Karolina Akinosoglou, Orestis Liatsis-Douvitsas, S. Symbardi, N. Gatselis, M. Mouktaroudi, G. Ippolito, E. Florou, A. Kotsaki, M. Netea, J. Eugen-Olsen, M. Kyprianou, P. Panagopoulos, G. Dalekos, E. Giamarellos‐Bourboulis   +63 more
semanticscholar   +1 more source

Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer

Journal of Translational Medicine, 2022
Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels in malignant tumours.
Bing-tao Zhai, Huan Tian, Jing Sun, Junbo Zou, Xiao-Fei Zhang, Jiangxue Cheng, Yajun Shi, Yu-Ze Fan, Dongyan Guo   +8 more
semanticscholar   +1 more source

Therapeutic Strategies Targeting Urokinase and Its Receptor in Cancer

Cancers, 2022
Simple Summary The uPA/uPAR system is highly involved in cancer progression and metastasis. Many studies have definitively assessed that the high expression of urokinase-type plasminogen activator (uPA) and membrane urokinase-type plasminogen activator ...
M. Masucci, M. Minopoli, G. Di Carluccio, M. L. Motti, M. Carriero   +4 more
semanticscholar   +1 more source

Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation

Frontiers in Immunology, 2021
Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation that plays a major role in immunosenescence and in development and progression of many diseases.
L. Rasmussen, J. E. V. Petersen, J. Eugen-Olsen   +2 more
semanticscholar   +1 more source

SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung

eLife, 2021
Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance.
Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Bruce Aronow, Daniel Jacobson   +7 more
doaj   +1 more source

Transcriptome Sequencing Identifies PLAUR as an Important Player in Patients With Dermatomyositis-Associated Interstitial Lung Disease

Frontiers in Genetics, 2021
Dermatomyositis (DM), an inflammatory disorder, is often associated with interstitial lung disease (ILD). However, the underlying mechanism remains unclear.
Juan Chen, Ruixian Zhang, Min Xie, Chunyan Luan, Xiaolan Li   +4 more
doaj   +1 more source

Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients

Romanian Journal of Laboratory Medicine, 2021
Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj   +1 more source

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
doaj   +1 more source