Results 31 to 40 of about 2,335,681 (277)

Involvement of Urokinase-Type Plasminogen Activator Receptor in the Formation of a Profibrotic Microenvironment in the Epicardial Region

Общая реаниматология, 2021
The study of the mechanisms of development and progression of fibrosis is one of the key directions of modern cardiology. Our work suggests that the urokinase receptor (uPAR) is involved in the regulation of mesothelial cell activity and epicardial ...
K. V. Dergilev, Z. I. Tsokolayeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuyev, B. N. Kulbitsky, E. V. Parfenova   +6 more
doaj   +1 more source

suPAR, a Circulating Kidney Disease Factor

Frontiers in Medicine, 2021
Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation.
Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser   +3 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Urokinase Regulates Vitronectin Binding by Controlling Urokinase Receptor Oligomerization [PDF]

Journal of Biological Chemistry, 2002
Adhesion of monocytes to the extracellular matrix is mediated by a direct high affinity interaction between cell-surface urokinase-type plasminogen activator (uPA) receptor (uPAR) and the extracellular matrix protein vitronectin. We demonstrate a tight connection between uPA-regulated uPAR oligomerization and high affinity binding to immobilized ...
N. SIDENIUS, A. ANDOLFO, FESCE, RICCARDO GIUSEPPE, F. BLASI   +3 more
openaire   +4 more sources

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Düzce Tıp Fakültesi Dergisi, 2021
Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt, Engin Şebin, Sibel İba Yılmaz, Ali Batur, Orhan Delice, Omer Karasahin, Kadir Küçükceran   +6 more
doaj   +1 more source

A Region in Domain II of the Urokinase Receptor Required for Urokinase Binding [PDF]

Journal of Biological Chemistry, 2000
The urokinase receptor is composed of three homologous domains based on disulfide spacing. The contribution of each domain to the binding and activation of single chain urokinase (scuPA) remains poorly understood. In the present paper we examined the role of domain II (DII) in these processes.
K, Bdeir, A, Kuo, A, Mazar, B S, Sachais, W, Xiao, S, Gawlak, S, Harris, A A, Higazi, D B, Cines   +8 more
openaire   +2 more sources

Role of Urokinase-Type Plasminogen Activator Receptor in the Regulation of Angiogenic Properties of Sca1+ Vasculogenic Progenitor Cells

Общая реаниматология, 2022
Neoangiogenesis is the key process determining myocardial regeneration after infarction. The urokinase-type plasminogen activator receptor (uPAR) is known to play an important role in the regulation of endothelial cell function and postnatal angiogenesis.
К. V. Dergilev, Z. I. Tsokolaeva, I. B. Beloglazova, Yu. D. Vasilets, D. O. Traktuev, N. B. Kulbitsky, E. V. Parfenova   +6 more
doaj   +1 more source

Regulation of Urokinase/Urokinase Receptor Interaction by Heparin-like Glycosaminoglycans [PDF]

Journal of Biological Chemistry, 2001
We show here that the interaction between the urokinase-type plasminogen activator and its receptor, which plays a critical role in cell invasion, is regulated by heparan sulfate present on the cell surface and in the extracellular matrix. Heparan sulfate oligomers showing a composition close to the dimeric repeats of heparin (glucosamine-NSO(3)(6-OSO ...
PUCCI, MARCO, FIBBI, GABRIELLA, MAGNELLI, LUCIA, DEL ROSSO, MARIO   +3 more
openaire   +3 more sources

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia

Critical Care, 2020
As of April 1, 2020, 885,689 cases of infections by the novel coronavirus SARS-CoV-2 (COVID-19) have been recorded worldwide; 44,217 of them have died (https:// www.worldometers.info/coronavirus).
N. Rovina, Karolina Akinosoglou, J. Eugen-Olsen, S. Hayek, J. Reiser, E. Giamarellos‐Bourboulis   +5 more
semanticscholar   +1 more source

Changes in levels of urokinase receptor and other components of fibrinolytic system in brain tissues in urokinase gene-knockout mice with B16/F10 melanoma growing together with chronic neurogenic pain

Исследования и практика в медицине, 2022
Purpose of the study. An analysis of the changes in components of the urokinase system in the brain of urokinase gene-knockout mice (uPA-/-) with B16/F10 melanoma growing alone and together with chronic neurogenic pain (CNP).Materials and methods.
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, N. D. Cheryarina, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. A. Nemashkalova   +7 more
doaj   +1 more source