Results 91 to 100 of about 4,311 (206)

Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by mitophagy induction

Figure 1. Effect of Urolithin A (UA) on hearing and the mitochondrial state.Figure 2. Effect of Urolithin A (UA) on expression levels of mitophagy-associated molecules and OXPHOS proteins in the cochlea.Figure 3.
Cho, S (via Mendeley Data), Cho, Sung Il
core   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, Volume 604, Issue 17, Page 7059-7075, 1 September 2026.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Microbial method for reproducing the human urolithin metabotypes in vitro and in vivo

, 2022
The present invention relates to a new bacterial strain and a new urolithin named urolithin G. The new strain of the invention is Enterocloster bolteae CEBAS S4A9 DSM 34392 and can customize urolithin production to mimic metabotype A and metabotype B in ...
Beltrán Riquelme, David, Selma, María Victoria, Tomás Barberán, Francisco, García-Villalba, Rocío, Espín de Gea, Juan Carlos   +4 more
core  

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source

Anti-inflammatory and Antioxidant Mechanism of Urolithin B in Activated Microglia

, 2018
Urolithin B is one of the gut microbial metabolites of ellagitannins, which have a number of biological activities such as anti-cancer, anti-microbial, anti-inflammatory, antioxidant, and neuroprotective effects. Urolithin B showed anti-cancer activities
이경진
core   +1 more source

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

, 2012
Numerous in vitro and in vivo studies indicate that ellagitannins exhibit anti-inflammatory, anti-atherosclerotic and anti-angiogenic activity which support their potential preventive effect against cardiovascular diseases.
Larrosa, Mar, Tomás Barberán, Francisco, Giménez-Bastida, J. A., González-Sarrías, Antonio, Espín de Gea, Juan Carlos, García-Conesa, María Teresa   +5 more
core   +1 more source

Induction of autophagy and activation of SIRT-1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and differentiated 3D human neural progenitor cells [PDF]

, 2019
Scope: Urolithin A is an anti-inflammatory and neuroprotective gut-derived metabolite from ellagitannins and ellagic acid in pomegranate, berries, and nuts. The roles of SIRT-1 and autophagy in the neuroprotective activity of urolithin A are investigated.
El-Bakoush, Abdelmeneim, Olajide, Olumayokun, Harsharan Bhatia, Katola, Folashade, Velagapudi, Ravikanth, El‐Bakoush, Abdelmeneim, Olumayokun A. Olajide, Ravikanth Velagapudi, Abdelmeneim El‐Bakoush, Bhatia, Harsharan, Lepiarz, Izabela, Fiebich, Bernd L., Bhatia, Harsharan S., Katola, Folashade O., Izabela Lepiarz, Folashade O. Katola, Bernd L. Fiebich, Olajide, Olumayokun A.   +17 more
core   +1 more source

Optimization of Medium and Transcriptomic Analysis for Converting Ellagic Acid to Urolithin A by Limosilactobacillus fermentum FUA033

Shipin gongye ke-ji
This study aimed to establish a systematic framework for enhancing the bioconversion efficiency of ellagic acid to urolithin A by Limosilactobacillus fermentum FUA033 through rational medium engineering, while deciphering the molecular orchestration ...
Gewen ZHANG, Liangliang QIAN, Wenmei ZHOU, Yanyan GONG, Tao CHEN, Yingling LIU, Yaowei FANG, Shu LIU   +7 more
doaj   +1 more source

Ellagitannins (Ellagic Acid, Urolithin A, Urolithin B) Inhibit the Catalytic Activity of Human Recombinant Metalloproteinase 9

Iranian Journal of Pharmaceutical Research
Background: Ellagitannins are well-recognized for their antioxidant, chemopreventive, anti-inflammatory, and neuroprotective efficacy. Due to their poor absorption and extensive catabolism, it is proposed that urolithins, as ellagic acid (EA) metabolites, are the real active molecules exerting these biological functions.
Houssein-Zadeh, Nigar, Sadeghi, Leila, Dehghan, Gholamreza   +2 more
openaire   +2 more sources

Determination of Urolithin A in Health Products by Ultra-High-Performance Liquid Chromatography

Molecules
This study establishes and validates a novel ultra-high-performance liquid chromatography (UHPLC) method for the determination of urolithin A content in health products, a bioactive compound with potential anti-aging properties.
Yue E, Zhuang Wang, Jiahui Nie
doaj   +1 more source