Results 81 to 90 of about 4,989 (225)

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster [PDF]

, 2017
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing.
A Rana, A Tanaka, AC Poole, AC Poole, AM Pickrell, AS Rambold, B DuBoff, C Lopez-Otin, CC Yang, CQ Scheckhuber, D Mathur, D Ryu, DC Chan, DC David, DC Rubinsztein, DJ Klionsky, DP Narendra, DR Green, DW Walker, E Beregi, E Dambroise, E Lionaki, E Owusu-Ansah, E Smirnova, E Ziviani, ES Vincow, F Demontis, G Ashrafi, G Twig, G Twig, GD Cartee, H Abeliovich, H Deng, H Nakatogawa, I Pimenta de Castro, IP Castro de, J Durieux, J Park, J Yun, JM Copeland, JP Leduc-Gaudet, K Kavanagh, K Mao, K Palikaras, L Buhlman, L Partridge, L Poirier, M Frank, M Kaeberlein, M Manczak, M Rera, M Rera, M Schrader, MJ Drummond, N Sun, N Sun, N Thevaranjan, NC Chan, P Reis-Rodrigues, R Coleman, R Kandimalla, RH Houtkooper, RJ Youle, RJ Youle, S Geisler, S Gelino, S Hoppins, S Iqbal, SE Wohlgemuth, WW Ja, X Wang, Y Wang, Y Yang   +72 more
core   +6 more sources

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

In vivo administration of gut bacterial consortia replicates urolithin metabotypes A and B in a non-urolithin-producing rat model

Food & Function, 2023
The two bacterial consortia colonized the intestine of rats and converted UM-0 (non-urolithin-producing) animals into urolithin-producing animals mimicking the UM-A and UM-B metabotypes.
Carlos E. Iglesias-Aguirre, Antonio González-Sarrías, Adrián Cortés-Martín, María Romo-Vaquero, Leire Osuna-Galisteo, José Joaquín Cerón, Juan Carlos Espín, María Victoria Selma   +7 more
openaire   +2 more sources

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Urolithins and their possible implications for diabetic kidney

European Journal of Translational and Clinical Medicine, 2022
The increasing prevalence of diabetic kidney disease (DKD), a common complication of type 1 and type 2 diabetes, is becoming a leading risk factor of developing end stage renal disease (ESRD). The multiple mechanisms involved in renal tissue damage are a challenge for effective targeted therapy.
Milena Kotewicz, Barbara Lewko
openaire   +2 more sources

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database [PDF]

, 2017
SCOPE: The Phenol-Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here we exploit these data to characterize and visualize the polyphenol metabolome, the set of all metabolites ...
Andrés Lacueva, Ma. Cristina, Barupal, Dinesh Kumar, Boto Ordóñez, María, Farran, Andreu, Llorach, Rafael, Manach, Claudine, Neveu, Vanessa, Rothwell, Joseph A., Scalbert, Augustin, Urpí Sardà, Mireia   +9 more
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Isolation and characterization of urolithin b from asphaltum [PDF]

Journal of Pharmacognosy and Phytochemistry, 2019
Asphaltum (vernacular name: Shilajit), is a traditional Ayurvedic medicine used as aphrodisiac. The present study was aimed for extraction, isolation, method development and validation of RP-HPLC method for bioactive compound called urolithin B (benzocoumarin) for Asphaltum. HPLC method was developed with the help of PDA detector for isolated compound.
Shefali Thakkar, Kirti Laddha
openaire   +1 more source

The effects of a (poly)phenol‐rich food intervention on markers of exercise‐induced inflammation and oxidative stress: A randomised controlled trial

Experimental Physiology, EarlyView.
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi, Josh Thorley, Ana Rodriguez‐Mateos, Zicheng Zhang, Lewis J James, Tom Clifford   +5 more
wiley   +1 more source

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion.
Elisa Bianconi, Anna Gidari, Maria Souma, Samuele Sabbatini, Deborah Grifagni, Carlo Bigiotti, Elisabetta Schiaroli, Lucia Comez, Alessandro Paciaroni, Francesca Cantini, Daniela Francisci, Antonio Macchiarulo   +11 more
doaj   +1 more source