Results 61 to 70 of about 3,172 (181)

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 7, July 2026.
In Alzheimer's disease, Aβ and Tau trigger mitochondrial dysfunction, driving a pathological cascade that results in cognitive decline. Gut microbiota dysbiosis exacerbates this via the gut–brain axis, making mitochondria a key therapeutic target. ABSTRACT Introduction Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis ...
Tianyi Gu, Hangyan Guo, Zixin Guo, Shengyu Hua   +3 more
wiley   +1 more source

Urolithin 9-dehydroxylase from Enterocloster bolteae JCM 12243T catalyzing regiospecific dehydroxylation of urolithins

Enzyme and Microbial Technology
Urolithins are metabolites derived from ellagic acid, a compound that is present in many plants, including pomegranate, via the action of gut microorganisms. Among them, urolithin A exhibits antioxidant and anti-inflammatory activity and promotes autophagy, making it a potential contributor to human health.
Anno, Katasho, Kanako, Kumazawa, Hiroko, Watanabe, Takanori, Nakajima, Natsuno, Chiba, Hiroaki, Yamamoto, Shigenobu, Kishino, Jun, Ogawa   +7 more
openaire   +2 more sources

RETRACTED: Kshirsagar et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease. Cells 2022, 11, 2660

Cells
The journal retracts the article titled “A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease” [...]
Sudhir Kshirsagar, Rainier Vladlen Alvir, Jangampalli Adi Pradeepkiran, Ashly Hindle, Murali Vijayan, Bhagavathi Ramasubramaniam, Subodh Kumar, Arubala P. Reddy, P. Hemachandra Reddy   +8 more
doaj   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, Volume 4, Issue 3, Page 721-736, July 2026.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Health Benefits and Molecular Mechanisms of Urolithin A: From a Gut Microbiota‐Derived Metabolite to Translational Applications

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Urolithin A (UA) is a gut microbiota‐derived metabolite produced from dietary ellagitannins and ellagic acid, with endogenous formation varying among urolithin metabotypes (UM‐A, UM‐B, and UM‐0). UA regulates an interconnected network centered on mitophagy and mitochondrial quality control, antioxidant defense, inflammatory signaling, autophagy, and ...
Zijiang Yang, Chenggen Guo, Ziao Deng, Xinxuan Xue   +3 more
wiley   +1 more source

Regulation of PD‐1PD‐L1 Immune Checkpoints by Gut Microbiota Metabolites and Their Clinical Translational Research: A Review

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Background Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 pathway have revolutionized cancer immunotherapy, yet their clinical benefit is constrained by variable response rates and immune‐related adverse events. Aims This review systematically analyzes the molecular mechanisms by which key gut microbiota‐derived metabolites ...
Xuanyou Fang, Shuai Yuan, Weijian Mai
wiley   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Cardiovascular Diabetology, 2017
Background Emerging evidence suggests that specific (poly)phenols may constitute new preventative strategies to counteract cell oxidative stress and myocardial tissue inflammation, which have a key role in the patho-physiology of diabetic cardiomyopathy.
Monia Savi, Leonardo Bocchi, Pedro Mena, Margherita Dall’Asta, Alan Crozier, Furio Brighenti, Donatella Stilli, Daniele Del Rio   +7 more
doaj   +1 more source

Urolithin-C Suppresses Inflammation by Blocking NF-κB Signaling Pathway in LPS-Induced RAW 264.7 Macrophages

Journal of Inflammation Research
Vani Karadi Manjappa,1,2,* Manjula Mavathuru Venkatappa,3,* Deepadarshan Urs,4 Suliphuldevara Mathada Basavarajaiah,5 Shivakumar Venkataramaiah,3 Sanjana Bai Shivramsingh Mahendranathsingh,1 Sushma Mohan,1 Hunase Rajaiah Pushpavathi,4 ...
Manjappa VK, Venkatappa MM, Urs D, Basavarajaiah SM, Venkataramaiah S, Mahendranathsingh SBS, Mohan S, Pushpavathi HR, Krishnappa DK, Sannaningaiah D   +9 more
doaj