Results 51 to 60 of about 3,172 (181)

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Identifying Brazilwood’s Marker Component, Urolithin C, in Historical Textiles by Surface-Enhanced Raman Spectroscopy

Heritage, 2021
The fugitive nature of the colorants obtained from sappanwood (Caesalpinia sappan L.) or the South American species commonly known as ‘brazilwoods’ (including other Caesalpinia species and Paubrasilia echinata (Lam.)) makes the identification of ...
Brenda Doherty, Ilaria Degano, Aldo Romani, Catherine Higgitt, David Peggie, Maria Perla Colombini, Costanza Miliani   +6 more
doaj   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

Applied Microbiology and Biotechnology
Abstract The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited.
Fuxiang He, Yingying Bian, Yaling Zhao, Mengjie Xia, Shu Liu, Jiajin Gui, Xiaoyue Hou, Yaowei Fang   +7 more
openaire   +2 more sources

Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Urolithin A (UA) treatment enhances the Nrf2/HO‐1‐mediated antioxidant capacity against ischemic injury postischemic stroke, while also effectively suppressing neuroinflammatory responses. Both of these regulatory effects are likely associated with the NF‐κB signaling pathway, which in turn inhibits neuronal apoptosis and contributes to the improvement
Yanxin Shao, Lina Feng, Yanchun Li, Yichen Cai, Hui Yuan, Qin Tang, Mingfeng Yang, Weixia Yang, Hong Shi, Leilei Mao   +9 more
wiley   +1 more source

The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent

Antioxidants, 2020
Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries.
Guillermo Cásedas, Francisco Les, Carmen Choya-Foces, Martín Hugo, Víctor López   +4 more
doaj   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Microbiome‐Phytochemical Crosstalk Along the Gut‐Brain Axis in Alzheimer and Parkinson's Disease

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Phytochemicals remodel the gut microbiota by enriching beneficial bacteria and microbial metabolites while suppressing dysbiosis and inflammation. Through modulation of the gut–brain axis, they restore intestinal barrier integrity, regulate neuroimmune and neuroprotective signaling pathways, reduce amyloid‐β, tau, and α‐synuclein pathology, and ...
Md. Emon, Md. Mizanur Rahaman, Dhrubo Sarder, Md. Shadin, Shamima Akter Neela, Phurpa Wangchuk, Subir Sarker   +6 more
wiley   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source