Results 51 to 60 of about 4,989 (225)

Urolithin A attenuates auditory cell senescence by activating mitophagy

Scientific Reports, 2022
AbstractAging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells.
Sung Il Cho, Eu-Ri Jo, Hansoo Song
openaire   +3 more sources

Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid

Frontiers in Nutrition, 2022
Urolithin A (UA) has received considerable research attention because of its health benefits. However, only a few strains have been reported to produce UA from ellagic acid (EA), and the molecular mechanisms underlying the gut microbiota-mediated ...
Xiaomeng Zhang, Xiaomeng Zhang, Xiaomeng Zhang, Yaowei Fang, Yaowei Fang, Yaowei Fang, Guang Yang, Guang Yang, Guang Yang, Xiaoyue Hou, Xiaoyue Hou, Xiaoyue Hou, Yang Hai, Mengjie Xia, Fuxiang He, Yaling Zhao, Yaling Zhao, Yaling Zhao, Shu Liu, Shu Liu, Shu Liu   +20 more
doaj   +1 more source

Gut metabolite Urolithin A mitigates ionizing radiation‐induced intestinal damage [PDF]

Journal of Cellular and Molecular Medicine, 2021
AbstractIonizing radiation (IR)‐induced intestinal damage is the major and common injury of patients receiving radiotherapy. Urolithin A (UroA) is a metabolite of the intestinal flora of ellagitannin, a compound found in fruits and nuts such as pomegranates, strawberries and walnuts.
Yuanyang Zhang, Yinping Dong, Ping Lu, Xinyue Wang, Wenxuan Li, Hui Dong, Saijun Fan, Deguan Li   +7 more
openaire   +2 more sources

Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents

Antioxidants, 2022
(1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants
Emily P. Laveriano-Santos, Paola Quifer-Rada, María Marhuenda-Muñoz, Camila Arancibia-Riveros, Anna Vallverdú-Queralt, Anna Tresserra-Rimbau, Ana María Ruiz-León, Rosa Casas, Ramon Estruch, Patricia Bodega, Mercedes de Miguel, Amaya de Cos-Gandoy, Jesús Martínez-Gómez, Gloria Santos-Beneit, Juan M. Fernández-Alvira, Rodrigo Fernández-Jiménez, Rosa M. Lamuela-Raventós   +16 more
doaj   +1 more source

The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]

, 2020
Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core   +1 more source

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols [PDF]

, 2017
(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood.
Actis-Goretta, Actis-Goretta, Actis-Goretta, Amin, Aura, Azzini, Baba, Baeza, Baldwin, Balentine, Barroso, Blaut, Boonpawa, Boto-Ordonez, Boto-Ordonez, Braune, Bredsdorff, Brett, Brown, Bäckhed, Chen, Cheynier, Claesson, Clifford, Clifford, Clifford, Clifford, Clifford, Collins, Crozier, Cuervo, da Encarnacao, da Silva-Pereira, Dall'asta, de, di Gesso, Duarte, Eid, Etxeberria, Fakhry, Fakhry, Farrell, Farrell, Felberg, Fernandez-Millan, Fournier, Garcia-Alvarez, Gary Williamson, Gaya, Gill, Goedert, Gonzalez-Barrio, Gonzalez-Barrio, Gross, Gu, Guglielmetti, Haddock, Harbowy, Haslam, Hengstmann, Hidalgo, Hollman, Hollman, Holt, Hong, Hoyles, Huang, Jacobs, Jacobs, Janssens, Jenner, Juan, Kasimsetty, Keane, Krga, Krumholz, Kuhnert, Kuhnert, Kuhnle, Kuhnle, Lambert, Lang, Li, Li, Li, Liu, Lommen, Low, Ludwig, Ma, Matthies, Mazzeo, Michael N. Clifford, Monti, Moreno-Indias, Mosele, Mosele, Mosele, Mullen, Mullen, Mullen, Nagy, Neveu, Nielsen, Nozaki, Olthof, Ottaviani, Park, Pascual-Teresa, Peng, Pereira-Caro, Pereira-Caro, Pereira-Caro, Pereira-Caro, Pimpao, Pimpao, Pinto, Plumb, Poquet, Price, Ravn-Haren, Regueiro, Renouf, Rhodes, Romo-Vaquero, Roopchand, Roowi, Saha, Said, Sanchez-Patan, Saura-Calixto, Scalbert, Schantz, Scherbl, Selma, Seo, Shaw, Shaw, Stalmach, Stalmach, Stalmach, Stevens, Stoupi, Stoupi, Stoupi, Tabasco, Taira, Takagaki, Takagaki, Takagaki, Takumi, Tognolini, Truchado, Unno, Vallejo, van der Pijl, van Dorsten, van Duynhoven, Vazquez-Fresno, Verloop, Vetrani, Vinha, Vitaglione, Vogtmann, Wadman, Walker, Wallace, Wang, Wang, Warner, Williamson, Woodward, Woting, Woting, Wu, Xue, Yassin, Yassin, Zamora-Ros, Zamora-Ros, Zamora-Ros, Zhang, Zhou   +182 more
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Exploring the role of LDH in cancer cells through the use of small-molecule inhibitors. [PDF]

, 2018
Metabolic reprogramming represents a potential therapeutic target in cancer. The studies of this thesis work lead to assume the enzyme lactate dehydrogenase (LDH) as key element coordinating neoplastic proliferation and invasive growth, suggesting for ...
Di Ianni, Lorenza <1987>
core   +1 more source

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

Pharmaceuticals, 2023
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis.
Umberto Maria Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, Woonghee Kim, Mathias Uhlen, Jan Borén, Adil Mardinoğlu, Morten Grøtli   +12 more
doaj   +1 more source

Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria [PDF]

, 2010
Background The sun-dried rind of the immature fruit of pomegranate (Punica granatum) is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt) in Orissa, India, for the therapy and prophylaxis of malaria.
Mario Dell'Agli, Germana V Galli, Michela Bulgari, Nicoletta Basilico, Sergio Romeo, Deepak Bhattacharya, Donatella Taramelli, Enrica Bosisio   +7 more
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Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor

Brain, Behavior, & Immunity - Health, 2020
Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii cysts in the brain.
Sijie Tan, Wen Han Tong, Ajai Vyas
doaj   +1 more source