Results 71 to 80 of about 4,311 (206)

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

Applied Microbiology and Biotechnology
Abstract The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited.
Fuxiang He, Yingying Bian, Yaling Zhao, Mengjie Xia, Shu Liu, Jiajin Gui, Xiaoyue Hou, Yaowei Fang   +7 more
openaire   +2 more sources

Identifying Brazilwood’s Marker Component, Urolithin C, in Historical Textiles by Surface-Enhanced Raman Spectroscopy

Heritage, 2021
The fugitive nature of the colorants obtained from sappanwood (Caesalpinia sappan L.) or the South American species commonly known as ‘brazilwoods’ (including other Caesalpinia species and Paubrasilia echinata (Lam.)) makes the identification of ...
Brenda Doherty, Ilaria Degano, Aldo Romani, Catherine Higgitt, David Peggie, Maria Perla Colombini, Costanza Miliani   +6 more
doaj   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract

, 2019
Urolithins are bioactive gut microbiota metabolites of ellagic acid. Here, we have identified four unknown urolithins in human feces after the intake of a pomegranate extract. The new metabolites occurred only in 19% of the subjects.
Rocío García-Villalba (2099278), Juan C. Espín (1961374), Francisco A. Tomás-Barberán (2099284), María V. Selma (2256445)   +3 more
core   +1 more source

Ellagic Acid Enhances RSL3‐Induced Ferroptosis by Inhibiting the Nrf2/HO‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Ellagic acid potentiates RSL3‐induced ferroptosis in PANC‐1 by suppressing the Nrf2/HO‐1 antioxidant defense axis via p38 MAPK activation and Keap1 upregulation. In PDAC cells, constitutive Nrf2/HO‐1 signaling establishes a robust antioxidant shield (GPX4, HO‐1) that limits lipid ROS accumulation and confers ferroptosis resistance.
Jianhua Bai, Yihe Dai, Chern Ein Oon, Pingping Hu, Jia Luo, Jiang Han, Liman Yang, Amirabas Bostani, Zhenhao Fei, Yun Jin   +9 more
wiley   +1 more source

Organoids in Precision Radiotherapy: Methodological Foundations, Tumor‐Specific Evidence, and Translational Roadmaps

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu, Yawei Jiao, Jiao Xue, Xiaoli Lv, Songbing Qin   +4 more
wiley   +1 more source

Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression

Clinical Cardiology, Volume 49, Issue 9, September 2026.
Proposed gut‐vascular framework linking microbial ecology to atherosclerotic disease. Diet and related exposures shape dysbiosis or microbial resilience; resulting changes in SCFAs, TMAO, bile acids, and LPS may modulate endothelial function, immune activation, and platelet activity, contributing to atherosclerosis, ACS, and PAD.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Usamah Sayed, Zarina Nasirova, Quvonch Tursunov, Omer Qutaiba B. Allela, Lara Asim Kzar, Rajashree Panigrahi, Neeraj Bainsal   +7 more
wiley   +1 more source

Urolithin A has antiplatelet effects in contrast to its glucuronide, urolithin B, and isourolithin A

Frontiers in Cardiovascular Medicine
IntroductionConsumption of dietary ellagitannins has been suggested to have protective effects against cardiovascular disease, likely due to the colonic formation of urolithins and their subsequent systemic absorption.
Alina Soloviova, Alina Soloviova, Marcel Hrubša, Carlos J. García, Zuzana Lomozová, Francisco A. Tomás-Barberán, Přemysl Mladěnka   +6 more
doaj   +1 more source

Oxidant‐ and Base‐Free Oxidative Lactonization of 2‐Arylbenzoic Acids in Two‐Molecule Photoredox System

ChemPhotoChem, Volume 10, Issue 9, September 2026.
Oxidant‐ and base‐free photoinduced oxidative lactonization of 2‐arylbenzoic acids in a two‐molecule photoredox system under an Ar atmosphere successfully provided the corresponding benzo‐3,4‐coumarins through oxidation by the protonated radical anion of 9,10‐dicyanoanthracene.
Sho Shimamura, Ryoga Hashimoto, Toshiki Furutani, Mugen Yamawaki, Hirotsugu Suzuki, Yasuharu Yoshimi   +5 more
wiley   +1 more source