The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent [PDF]
Antioxidants, 2020 Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries.
Guillermo Cásedas +4 more
doaj +3 more sources
Mitigating Pro-Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy. [PDF]
Aging CellSenescent cells are known to contribute to aging and age-related diseases. One key way they influence aging is by secreting senescence-associated secretory phenotype (SASP) factors along with several damage-associated molecular pattern (DAMP) molecules ...
Barkovskaya A +7 more
europepmc +2 more sources
Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor
Brain, Behavior, & Immunity - Health, 2020 Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii cysts in the brain.
Sijie Tan, Wen Han Tong, Ajai Vyas
doaj +3 more sources
Systemic Inflammation and the Inflammatory Context of the Colonic Microenvironment Are Improved by Urolithin A. [PDF]
Cancer Prev Res (Phila)We evaluate cancer-protective effects of walnuts via formation of microbe-derived urolithin A, substantiating their functional benefits on serum inflammatory markers and immunologic composition of polyps in normal/obese subjects.
Moussa MR +15 more
europepmc +2 more sources
Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. [PDF]
Sports MedUrolithin A (UA) is a metabolite produced by gut bacteria following the consumption of ellagitannin-rich foods. Clinical trials in middle-aged and older adults demonstrated that supplementation with UA improves muscle strength, endurance, and biomarkers ...
Whitfield J +10 more
europepmc +2 more sources
Applied Microbiology and BiotechnologyThe metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited. In this study, we conducted in vitro
Fuxiang He +7 more
semanticscholar +3 more sources
Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy [PDF]
MoleculesPeriodontitis is an inflammatory disease that affects the periodontal supporting tissues. Its cardinal clinical manifestations encompass gingival inflammation, periodontal pocket formation, and alveolar bone resorption. Urolithin A (UA), a gut microbiota-
Yishu Xia +4 more
doaj +2 more sources
Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1
Scientific ReportsOsteosarcoma is an aggressive malignancy marked by a high incidence of local recurrence and distant metastasis, leading to poor outcomes in advanced stages.
Abdolreza Ahmadi +3 more
doaj +2 more sources
Immunomodulatory Role of Urolithin A on Metabolic Diseases [PDF]
Biomedicines, 2021 Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties.
Ashley Mulcahy Toney +4 more
openaire +4 more sources
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries [PDF]
Frontiers in Pharmacology, 2021 Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading are not fully understood.
Yuchen He +7 more
openaire +3 more sources