Results 41 to 50 of about 21,131,763 (241)

Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D

Biochemistry and Biophysics Reports, 2020
Mediated by the nuclear vitamin D receptor (VDR), the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D), is known to regulate expression of genes impacting calcium and phosphorus metabolism, the immune system, and behavior ...
Sarah Livingston, Sanchita Mallick, Daniel A. Lucas, Marya S. Sabir, Zhela L. Sabir, Hespera Purdin, Sree Nidamanuri, Carol A. Haussler, Mark R. Haussler, Peter W. Jurutka   +9 more
doaj   +1 more source

A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease [PDF]

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. The classical AD brain is characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates as senile plaques and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated forms of the microtubule ...
Dona P. W. Jayatunga, Eugene Hone, Eugene Hone, W. M. A. D. Binosha Fernando, Manohar L. Garg, Manohar L. Garg, Giuseppe Verdile, Giuseppe Verdile, Ralph N. Martins, Ralph N. Martins, Ralph N. Martins   +10 more
openaire   +4 more sources

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Frontiers in Endocrinology, 2022
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease ...
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Cláudia N. dos Santos, Regina Menezes, Regina Menezes, Regina Menezes   +15 more
doaj   +1 more source

Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10^−/− Mice

Pathogens, 2020
Human campylobacteriosis represents an infectious enteritis syndrome caused by Campylobacter species, mostly Campylobacter jejuni. Given that C. jejuni infections are rising worldwide and antibiotic treatment is usually not indicated, novel treatment ...
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat   +3 more
doaj   +1 more source

Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED Study [PDF]

, 2017
The beneficial impact of walnuts on human health has been attributed to their unique chemical composition. In order to characterize the dietary walnut fingerprinting, spot urine samples from two sets of 195 (training) and 186 (validation) individuals ...
Andrés Lacueva, Ma. Cristina, Corella Piquer, Dolores, Estruch Riba, Ramon, Fitó Colomer, Montserrat, Garcia Aloy, Mar, Llorach, Rafael, Martínez-González, Miguel Ángel, 1957-, Ros Rahola, Emilio, Salas Salvadó, Jordi, Tulipani, Sara, Urpí Sardà, Mireia   +10 more
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Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells [PDF]

, 2015
Walnuts have been gathering attention for their health-promoting properties. They are rich in polyphenols, mainly ellagitannins (ETs) that after consumption are hydrolyzed to release ellagic acid (EA).
Ciudad i Gómez, Carlos Julián, Izquierdo Pulido, Maria, Noé Mata, Verónica, Sánchez González, Claudia Alejandra   +3 more
core   +1 more source

In vivo administration of gut bacterial consortia replicates urolithin metabotypes A and B in a non-urolithin-producing rat model

Food & Function, 2023
The two bacterial consortia colonized the intestine of rats and converted UM-0 (non-urolithin-producing) animals into urolithin-producing animals mimicking the UM-A and UM-B metabotypes.
Carlos E. Iglesias-Aguirre, Antonio González-Sarrías, Adrián Cortés-Martín, María Romo-Vaquero, Leire Osuna-Galisteo, José Joaquín Cerón, Juan Carlos Espín, María Victoria Selma   +7 more
openaire   +2 more sources

Urolithin A targets the AKT/WNK1 axis to induce autophagy and exert anti-tumor effects in cholangiocarcinoma

Frontiers in Oncology, 2022
Urolithin A (UA; 3,8-dihydroxybenzo[c]chromen-6-one), a metabolite generated by intestinal bacteria during the biotransformation of ellagitannins, has gained considerable attention in treating several cancers.
Hidenori Sahashi, Akihisa Kato, Michihiro Yoshida, Kazuki Hayashi, Itaru Naitoh, Yasuki Hori, Makoto Natsume, Naruomi Jinno, Kenta Kachi, Go Asano, Tadashi Toyohara, Yusuke Kito, Sudhakar Ammanamanchi, Hiromi Kataoka   +13 more
doaj   +1 more source

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Food Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso   +5 more
doaj   +1 more source

Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells [PDF]

, 2012
In this study, the anti-allergy potency of thirteen tannins isolated from the galls on buds of Carpinus tschonoskii (including two tannin derivatives) was investigated.
Han Junkyu, Isoda Hiroko, Ono Takako, Shigemori Hideyuki, Yamada Parida, 礒田 博子, 繁森 英幸, 韓 畯奎   +7 more
core   +1 more source