Results 61 to 70 of about 21,131,763 (241)

Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase

Pharmaceuticals, 2023
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis.
Umberto Maria Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, Woonghee Kim, Mathias Uhlen, Jan Borén, Adil Mardinoğlu, Morten Grøtli   +12 more
doaj   +1 more source

Perspective: Metabotyping-A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease [PDF]

, 2019
Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease.
Agneta, Rostgaard-Hansen,,, Anne, Tjønneland,,, Claudia, Vetrani,,, Cristina, Andres-Lacueva,,, Estanyol, Torres, Núria,, Gabriele, Riccardi,,, Giuseppina, Costabile,,, Jens, Nielsen,,, Jytte, Halkjær,,, Lin, Shi,,, Lingqun, Ye, Ye,, Palmnäs, Marie, Brunius, Carl,, Raul, Zamora-Ros,,, Raúl, González-Domínguez,,, Rikard, Landberg,,, Rosalba, Giacco,,   +15 more
core   +1 more source

Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]

, 2021
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Fernando B, Garg ML, Guillemin GJ, Hone E, Jayatunga DPW, Khaira H, Lunelli T, Martins RN, Singh H, Verdile G   +9 more
core   +2 more sources

Diet-derived urolithin A is produced by a dehydroxylase encoded by human gut Enterocloster species

Nature Communications
Urolithin A (uroA) is a polyphenol derived from the multi-step metabolism of dietary ellagitannins by the human gut microbiota. Once absorbed, uroA can trigger mitophagy and aryl hydrocarbon receptor signaling pathways, altering host immune function ...
Reilly Pidgeon, Sacha Mitchell, Michael Shamash, Layan Suleiman, Lharbi Dridi, C. Maurice, Bastien Castagner   +6 more
semanticscholar   +1 more source

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols [PDF]

, 2017
(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood.
Actis-Goretta, Actis-Goretta, Actis-Goretta, Amin, Aura, Azzini, Baba, Baeza, Baldwin, Balentine, Barroso, Blaut, Boonpawa, Boto-Ordonez, Boto-Ordonez, Braune, Bredsdorff, Brett, Brown, Bäckhed, Chen, Cheynier, Claesson, Clifford, Clifford, Clifford, Clifford, Clifford, Collins, Crozier, Cuervo, da Encarnacao, da Silva-Pereira, Dall'asta, de, di Gesso, Duarte, Eid, Etxeberria, Fakhry, Fakhry, Farrell, Farrell, Felberg, Fernandez-Millan, Fournier, Garcia-Alvarez, Gary Williamson, Gaya, Gill, Goedert, Gonzalez-Barrio, Gonzalez-Barrio, Gross, Gu, Guglielmetti, Haddock, Harbowy, Haslam, Hengstmann, Hidalgo, Hollman, Hollman, Holt, Hong, Hoyles, Huang, Jacobs, Jacobs, Janssens, Jenner, Juan, Kasimsetty, Keane, Krga, Krumholz, Kuhnert, Kuhnert, Kuhnle, Kuhnle, Lambert, Lang, Li, Li, Li, Liu, Lommen, Low, Ludwig, Ma, Matthies, Mazzeo, Michael N. Clifford, Monti, Moreno-Indias, Mosele, Mosele, Mosele, Mullen, Mullen, Mullen, Nagy, Neveu, Nielsen, Nozaki, Olthof, Ottaviani, Park, Pascual-Teresa, Peng, Pereira-Caro, Pereira-Caro, Pereira-Caro, Pereira-Caro, Pimpao, Pimpao, Pinto, Plumb, Poquet, Price, Ravn-Haren, Regueiro, Renouf, Rhodes, Romo-Vaquero, Roopchand, Roowi, Saha, Said, Sanchez-Patan, Saura-Calixto, Scalbert, Schantz, Scherbl, Selma, Seo, Shaw, Shaw, Stalmach, Stalmach, Stalmach, Stevens, Stoupi, Stoupi, Stoupi, Tabasco, Taira, Takagaki, Takagaki, Takagaki, Takumi, Tognolini, Truchado, Unno, Vallejo, van der Pijl, van Dorsten, van Duynhoven, Vazquez-Fresno, Verloop, Vetrani, Vinha, Vitaglione, Vogtmann, Wadman, Walker, Wallace, Wang, Wang, Warner, Williamson, Woodward, Woting, Woting, Wu, Xue, Yassin, Yassin, Zamora-Ros, Zamora-Ros, Zamora-Ros, Zhang, Zhou   +182 more
core   +1 more source

A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols. [PDF]

, 2020
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms are poorly ...
Balskus, Emily P, Bess, Elizabeth N, Bisanz, Jordan E, Kiamehr, Sina, Le, Chip, Luescher, Michael U, Maini Rekdal, Vayu, Nol Bernadino, Paola, Turnbaugh, Peter J   +8 more
core   +1 more source

Exploring the role of LDH in cancer cells through the use of small-molecule inhibitors. [PDF]

, 2018
Metabolic reprogramming represents a potential therapeutic target in cancer. The studies of this thesis work lead to assume the enzyme lactate dehydrogenase (LDH) as key element coordinating neoplastic proliferation and invasive growth, suggesting for ...
Di Ianni, Lorenza <1987>
core   +1 more source

Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography [PDF]

, 2023
Producción CientíficaUrolithins are gut microbiota metabolites produced in humans after consuming foods containing ellagitannins and ellagic acid. Three urolithin metabotypes have been reported for different individuals depending on the final urolithins ...
Althobaiti, Yusuf, Ares Sacristán, Ana María, Bernal del Nozal, José, García Villalba, Rocío, Tomás Barberán, Francisco A., Toribio Recio, Laura, Villalgordo, Jose M.   +6 more
core   +1 more source

Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist [PDF]

Metabolites, 2018
Urolithins (e.g., UroA and B) are gut microbiota-derived metabolites of the natural polyphenol ellagic acid. Urolithins are associated with various health benefits, including attenuation of inflammatory signaling, anti-cancer effects and repression of lipid accumulation.
Gulsum E. Muku, Iain A. Murray, Juan C. Espín, Gary H. Perdew   +3 more
openaire   +4 more sources

Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

Frontiers in Pharmacology, 2022
Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy.
Huaqiang Tao, Yunxia Tao, Chen Yang, Wenming Li, Wei Zhang, Xueyan Li, Ye Gu, Yujing Hong, Huilin Yang, Yu Liu, Xing Yang, Dechun Geng, Dechun Geng   +12 more
doaj   +1 more source