Functional Food-Derived Urolithins: Molecular Mechanisms, Health Effects, and Interactomics with Proteins and Extracellular Vesicles [PDF]
MoleculesOver the past decade, research on urolithins has expanded significantly due to their role as mediators between polyphenol-rich diets and human health. Understanding the relationships between ellagitannin intake, gut microbiota composition, and urolithin ...
Nevena Zelenović +2 more
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The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species [PDF]
npj Biofilms and MicrobiomesUrolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon +3 more
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Urolithins’ interaction with hepatocyte growth factor receptor: a mechanistic basis for anticancer activity in gastric adenocarcinoma cells [PDF]
Discover OncologyGastric adenocarcinoma (GAC) ranks among the most common cancers worldwide. Hepatocyte growth factor receptor, also known as MET, plays crucial roles in GAC progression.
Fatemehsadat Hosseini +4 more
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Promoting cognitive health through the nexus of gut microbiota and dietary phytochemicals [PDF]
Frontiers in NutritionThe intricate interactions between gut microbiota and cognitive function have become a forefront topic at the convergence of neuroscience and nutrition.
Lin Luo, Lin Luo
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Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives [PDF]
MoleculesThe present review offers a comprehensive synthesis of the structural diversity, natural occurrence, and therapeutic promise of key ellagitannins (punicalagin, sanguiin H-6, corilagin, geraniin, oenothein B, chebulagic, and chebulinic acids) within the ...
Rositsa Mihaylova +3 more
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From rumen to milk: Dietary polyphenols in dairy cows—A critical review [PDF]
Veterinary and Animal SciencePolyphenols represent a large and structurally diverse family of plant secondary metabolites with bioactive properties. In ruminants, these compounds can influence rumen fermentation, microbial ecology, and nutrient metabolism, offering potential ...
Lucrezia Forte +9 more
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A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin [PDF]
MoleculesSecondary polyphenol metabolites, urolithins (UROs), have anti-oxidative, anti-inflammatory, and antidiabetic properties. Therefore, their biological activity relies on blood transport via human serum albumin (HSA) and tissue distribution.
Nevena Zelenović +5 more
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In Vitro Anti-Inflammatory and Anticancer Potential of Pecan Nut (Carya illinoinensis) Kernel Extracts: Modulation of Cell Signaling Pathways—A Scoping Review [PDF]
MoleculesThis scoping review synthesized evidence from 2015 to 2025 on the anti-inflammatory and anticancer potential of pecan (Carya illinoinensis) kernel extracts, focusing on bioactive composition and cell signaling pathway modulation.
Ifeoma Roseline Ezeanolue +5 more
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Metabolomic insights into the prebiotic and metabolic regulatory properties of ellagic acid and urolithins on probiotic-like bacteria in vitro [PDF]
Current Research in Microbial SciencesMounting evidence suggests that dietary polyphenols exert health benefits partly through their favorable interactions with gut bacteria. However, little is known about polyphenol’s metabolic regulatory effects towards individual bacteria at the molecular
Yang Yang +3 more
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The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion.
Elisa Bianconi +11 more
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