Results 11 to 20 of about 2,363 (194)
Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies [PDF]
AntioxidantsPolyphenols, plant-derived secondary metabolites, play crucial roles in plant stress responses, growth regulation, and environmental interactions. In humans, polyphenols are associated with various health benefits, particularly in cardiometabolic health.
Ana Clara da C. Pinaffi-Langley +3 more
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Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy [PDF]
MicrobiomeBackground Gut microbiota-derived urolithins may influence multiple myeloma (MM) disease progression and treatment. We analyzed urolithins and their associated microbiota in a retrospective cohort of 45 patients with active MM or premalignant disease ...
Alba Rodríguez-García +18 more
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Therapeutic Potential of Ellagic Acid in Liver Diseases [PDF]
MoleculesEllagic acid (EA) is a natural polyphenol found in various fruits, nuts, and mushrooms. It exhibits a variety of biological activities, including potent antioxidant, anti-inflammatory, anti-obesity, and neuroprotective properties.
Karolina Wojtunik-Kulesza +5 more
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Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis [PDF]
AntioxidantsObesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatitis ...
Tharani Senavirathna +3 more
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Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes [PDF]
Nutrients, 2021 Diabetes remains one of the leading causes of deaths and co-morbidities in the world, with tremendous human, social and economic costs. Therefore, despite therapeutics and technological advancements, improved strategies to tackle diabetes management are still needed. One of the suggested strategies is the consumption of (poly)phenols. Positive outcomes
Ana F. Raimundo +4 more
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Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety [PDF]
International Journal of Molecular Sciences, 2021 We previously reported (E)-β-phenyl-α,β-unsaturated carbonyl scaffold ((E)-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of the scaffold resulted in the greatest tyrosinase inhibitory activity.
Sanggwon Lee +13 more
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Urolithins and intestinal health
Drug Discoveries & Therapeutics, 2022 There are trillions of microorganisms in the human intestine. They can react to the intestinal microenvironment by metabolizing food or producing small molecular compounds to affect the host's digestive ability and resist the risk of infection and autoimmune diseases.
Chunhua, Lu +4 more
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Immunomodulatory Role of Urolithin A on Metabolic Diseases [PDF]
Biomedicines, 2021 Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties.
Ashley Mulcahy Toney +4 more
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Frontiers in Nutrition, 2022 Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its in vivo metabolites called urolithins.
Hui-Lin Li +27 more
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Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives
Frontiers in Nutrition, 2022 Selective estrogen receptor modulators (SERMs) have been used in hormone related disorders, and their role in clinical medicine is evolving. Tamoxifen and raloxifen are the most commonly used synthetic SERMs, and their long-term use are known to create ...
Ravindran Vini +8 more
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