Results 21 to 30 of about 2,363 (194)

Urolithins: A Prospective Alternative against Brain Aging

Nutrients, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei, Lu, Qiu, Wang, Ke, Wang, Yousheng   +3 more
openaire   +2 more sources

Total Syntheses of Sappanin-Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization. [PDF]

Chem Asian J
A unified synthetic strategy enables the total syntheses of sappanin‐based natural products from a common privileged intermediate derived from cyclic vinylogous esters. Abstract Described is a concise route to caesappins A and B, urolithin C, and protosappanin A, which share a common sappanin core.
Zhao WT, Liang JY, Wu YK.
europepmc   +2 more sources

NMR Spectroscopic Identification of Urolithin G, a Novel Trihydroxy Urolithin Produced by Human Intestinal Enterocloster Species

Journal of Agricultural and Food Chemistry, 2023
Urolithins are gut microbiota metabolites of ellagic acid. Here, we have identified and chemically characterized a novel urolithin produced from urolithin D (3,4,8,9-tetrahydroxy urolithin) by in vitro incubation with different human gut Enterocloster species under anaerobic conditions. Urolithin G (3,4,8-trihydroxy urolithin) was identified by 1H NMR,
David Beltrán, María D. Frutos-Lisón, Rocío García-Villalba, José E. Yuste, Victor García, Juan C. Espín, María V. Selma, Francisco A. Tomás-Barberán   +7 more
openaire   +2 more sources

Urolithins Modulate the Viability, Autophagy, Apoptosis, and Nephrin Turnover in Podocytes Exposed to High Glucose

Cells, 2022
Urolithins are bioactive compounds generated in human and animal intestines because of the bacterial metabolism of dietary ellagitannins (and their constituent, ellagic acid).
Milena Kotewicz, Mirosława Krauze-Baranowska, Agnieszka Daca, Agata Płoska, Sylwia Godlewska, Leszek Kalinowski, Barbara Lewko   +6 more
doaj   +1 more source

Urolithin A alleviates neuropathic pain and activates mitophagy

Molecular Pain, 2023
Neuropathic pain (NP) occurs frequently in the general population and has a negative impact on the quality of life. There is no effective therapy available yet owing to the complex pathophysiology of NP. In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting ...
Chenyi Wang, Zizhu Wang, Shiyu Xue, Yutong Zhu, Jiahao Jin, Qiuyu Ren, Xiaodong Shi   +6 more
openaire   +2 more sources

Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries [PDF]

Frontiers in Pharmacology, 2021
Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading are not fully understood.
Yuchen He, Yuchen He, Lauren Yocum, Peter G Alexander, Michael J Jurczak, Hang Lin, Hang Lin, Hang Lin   +7 more
openaire   +3 more sources

Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Oxidative stress is a state of excess of prooxidative species relative to the antioxidant defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this imbalance is damage of the major cellular macromolecules (carbohydrates, lipids, proteins, and DNA), which further leads to a gradual loss of tissue and organ function. It has been
Jasmina Djedjibegovic, Aleksandra Marjanovic, Emiliano Panieri, Luciano Saso   +3 more
openaire   +2 more sources

In Silico and In Vitro Study of Antioxidant Potential of Urolithins

Antioxidants, 2023
In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut microbiota metabolites of the natural polyphenols ellagitannins (ETs) and ellagic acid (EA ...
Emanuela Marchese, Valentina Orlandi, Federica Turrini, Isabella Romeo, Raffaella Boggia, Stefano Alcaro, Giosuè Costa   +6 more
doaj   +1 more source

Ellagic acid inhibits bladder cancer invasiveness and in vivo tumor growth [PDF]

, 2016
Ellagic acid (EA) is a polyphenolic compound that can be found as a naturally occurring hydrolysis product of ellagitannins in pomegranates, berries, grapes, green tea and nuts.
Atzori, Mg, Bonanno, E, Ceci, C, Cicconi, R, De Martino, Mg, Graziani, G, Lacal, Pm, Mattei, M, Miano, R, Scimeca, M, Tentori, L, Vespasiani, G   +11 more
core   +7 more sources

Do Pomegranate Hydrolyzable Tannins and Their Derived Metabolites Provide Relief in Osteoarthritis? Findings from a Scoping Review

Molecules, 2022
Osteoarthritis (OA) is the most common form of arthritis affecting both the elderly and the middle-aged population. Although various therapeutics have been developed to arrest the structural deterioration of cartilage, the current treatments are limited ...
Marco Govoni, Francesca Danesi
doaj   +1 more source