Results 51 to 60 of about 2,363 (194)

Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review

Molecules, 2020
Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA).
Dmitry D. Evtyugin, Sandra Magina, Dmitry V. Evtuguin   +2 more
doaj   +1 more source

Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β stimulated SK-N-SH cells [PDF]

, 2015
Purpose: Pomegranate fruit, Punica granatum L. (Punicaceae) and its constituents have been shown to inhibit inflammation. In this study we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β stimulated SK-N-SH cells.
A Oucharif, B Romier, B Romier-Crouzet, CH Chen, CJ Lee, D Bialonska, D Paris, DJ Selkoe, EM Sutinen, F Lei, G Marwarha, GM Pasinetti, GP Lim, K Blennow, K Messmer, K Yasojima, KR Bales, KZ Bourne, M Guglielmotto, M Shukla, NP Seeram, NP Seeram, NT HoshinoT, OA Olajide, OA Olajide, RK Castellani, S Ahmed, S Camandola, S Sinha, SI Lee, T Decker, TJ Montine, V Buggia-Prevot, Y Farbood, Y Luo   +34 more
core   +1 more source

Urolithin A attenuates auditory cell senescence by activating mitophagy

Scientific Reports, 2022
AbstractAging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells.
Sung Il Cho, Eu-Ri Jo, Hansoo Song
openaire   +3 more sources

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid

Frontiers in Microbiology, 2017
Urolithins are intestinal microbial metabolites produced from ellagitannin- and ellagic acid-containing foods such as walnuts, strawberries, and pomegranates.
María V. Selma, David Beltrán, María C. Luna, María Romo-Vaquero, Rocío García-Villalba, Alex Mira, Juan C. Espín, Francisco A. Tomás-Barberán   +7 more
doaj   +1 more source

Microbial Metabolites in Multiple Sclerosis: Implications for Pathogenesis and Treatment

Frontiers in Neuroscience, 2022
Metabolites produced by the gut microbiota have been shown to play an important role in numerous inflammatory, neuropsychiatric, and neurodegenerative diseases.
Eduardo Duarte-Silva, Eduardo Duarte-Silva, Eduardo Duarte-Silva, Eduardo Duarte-Silva, Sven G. Meuth, Christina Alves Peixoto, Christina Alves Peixoto   +6 more
doaj   +1 more source

Gut metabolite Urolithin A mitigates ionizing radiation‐induced intestinal damage [PDF]

Journal of Cellular and Molecular Medicine, 2021
AbstractIonizing radiation (IR)‐induced intestinal damage is the major and common injury of patients receiving radiotherapy. Urolithin A (UroA) is a metabolite of the intestinal flora of ellagitannin, a compound found in fruits and nuts such as pomegranates, strawberries and walnuts.
Yuanyang Zhang, Yinping Dong, Ping Lu, Xinyue Wang, Wenxuan Li, Hui Dong, Saijun Fan, Deguan Li   +7 more
openaire   +2 more sources

Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]

, 2021
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Fernando B, Garg ML, Guillemin GJ, Hone E, Jayatunga DPW, Khaira H, Lunelli T, Martins RN, Singh H, Verdile G   +9 more
core   +2 more sources

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols [PDF]

, 2017
(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood.
Actis-Goretta, Actis-Goretta, Actis-Goretta, Amin, Aura, Azzini, Baba, Baeza, Baldwin, Balentine, Barroso, Blaut, Boonpawa, Boto-Ordonez, Boto-Ordonez, Braune, Bredsdorff, Brett, Brown, Bäckhed, Chen, Cheynier, Claesson, Clifford, Clifford, Clifford, Clifford, Clifford, Collins, Crozier, Cuervo, da Encarnacao, da Silva-Pereira, Dall'asta, de, di Gesso, Duarte, Eid, Etxeberria, Fakhry, Fakhry, Farrell, Farrell, Felberg, Fernandez-Millan, Fournier, Garcia-Alvarez, Gary Williamson, Gaya, Gill, Goedert, Gonzalez-Barrio, Gonzalez-Barrio, Gross, Gu, Guglielmetti, Haddock, Harbowy, Haslam, Hengstmann, Hidalgo, Hollman, Hollman, Holt, Hong, Hoyles, Huang, Jacobs, Jacobs, Janssens, Jenner, Juan, Kasimsetty, Keane, Krga, Krumholz, Kuhnert, Kuhnert, Kuhnle, Kuhnle, Lambert, Lang, Li, Li, Li, Liu, Lommen, Low, Ludwig, Ma, Matthies, Mazzeo, Michael N. Clifford, Monti, Moreno-Indias, Mosele, Mosele, Mosele, Mullen, Mullen, Mullen, Nagy, Neveu, Nielsen, Nozaki, Olthof, Ottaviani, Park, Pascual-Teresa, Peng, Pereira-Caro, Pereira-Caro, Pereira-Caro, Pereira-Caro, Pimpao, Pimpao, Pinto, Plumb, Poquet, Price, Ravn-Haren, Regueiro, Renouf, Rhodes, Romo-Vaquero, Roopchand, Roowi, Saha, Said, Sanchez-Patan, Saura-Calixto, Scalbert, Schantz, Scherbl, Selma, Seo, Shaw, Shaw, Stalmach, Stalmach, Stalmach, Stevens, Stoupi, Stoupi, Stoupi, Tabasco, Taira, Takagaki, Takagaki, Takagaki, Takumi, Tognolini, Truchado, Unno, Vallejo, van der Pijl, van Dorsten, van Duynhoven, Vazquez-Fresno, Verloop, Vetrani, Vinha, Vitaglione, Vogtmann, Wadman, Walker, Wallace, Wang, Wang, Warner, Williamson, Woodward, Woting, Woting, Wu, Xue, Yassin, Yassin, Zamora-Ros, Zamora-Ros, Zamora-Ros, Zhang, Zhou   +182 more
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The Compound Specific Antibacterial Activities of Major Urolithins and Their Methyl Ethers

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
The investigation of biological activities of natural products, particularly considering the secondary metabolites, continuously receives attention.
Hayrettin Ozan GÜLCAN, Mehmet İLKTAÇ, Bahareh NOSHADİ, Karar SHUKUR, Mustafa GAZİ   +4 more
doaj   +1 more source

Antioxidant and Antiglycation Effects of Cistus × incanus Water Infusion, Its Phenolic Components, and Respective Metabolites

Molecules, 2022
Reactive oxygen and carbonyl species promote oxidative and carbonyl stress, and the development of diabetes, metabolic syndrome, cardiovascular diseases, and others. The traditional herb Cistus × incanus is known for its antioxidant properties; therefore,
Karolina Bernacka, Katarzyna Bednarska, Aneta Starzec, Sylwester Mazurek, Izabela Fecka   +4 more
doaj   +1 more source