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Synthetic Nanoparticles for Vaccines and Immunotherapy [PDF]

Chemical Reviews, 2015
The immune system plays a critical role in our health. No other component of human physiology plays a decisive role in as diverse an array of maladies, from deadly diseases with which we are all familiar to equally terrible esoteric conditions: HIV ...
Adamina M., Ahn S., Alizadeh D., Alvarez I. B., Amanna I. J., Amigorena S., Anderson R. P., Arias M. a, Ataman-Onal Y., Bachmann M. F., Bachmann M. F., Bagchi A., Bal S. M., Banchereau J., Barhate G., Barhate G., Beduneau A., Beeton C., Benson D. M., Bershteyn A., Bertholon I., Black M., Blander J. M., Blander J. M., Bonnaud C., Brandtzaeg P., Broaders K. E., Brode S., Brown J. M., Burchill M. A., Bures P., Cario E., Carrasco Y. R., Centers for Disease Control and Prevention, Cerutti A., Cha E., Chabot S., Chabot S. M., Chackerian B., Chackerian B., Champion J. A., Champion J. A., Chang L.-J., Choi J., Chou L. Y. T., Clark R. A., Couzin-Frankel J., Crespo J., Cruz L. J., Cu Y., Darrell J. Irvine, Davis M. E., Davis M. J., De Titta A., Demento S. L., Demento S. L., Demento S. L., Deretic V., Desai M. P., Di Giacomo A. M., Dijkstra J. A. N., Dintzis H. M., Dintzis R. Z., Diwan M., Dolina J. S., Dostert C., Dou H., Dou H., Dudeja P. K., Duivenvoorden R., Eisenbarth S. C., Elamanchili P., Endsley A. N., Ensign L. M., Ensign L. M., Fahmy T. M., Fang R. H., Fernandez-Urrusuno R., Fievez V., Fife B. T., Fifis T., Fifis T., Foged C., Franchi L., Fraser C. C., Freeling J. P., Friede M., Fröhlich E., Gallucci S., Gatto D., Gebril A., Gerner M. Y., Getts D. R., Gharagozloo M., Gilliet M., Glenn G. M., Grupp S. A., Gungor B., Gupta P. N., Gupta P. N., Hajdu P., Hamad I., Hamdy S., Hamdy S., Hanlon D. J., Hanniffy S. B., Hanson M. C., Harde H., Harding C. V., Harding C. V., Harris J., Hasegawa T., Hejazi R., Helling F., Himeno A., Hirosue S., Hodi F. S., Hoffmann E., Hornung V., Hu Y., Hu Y., Hunter Z., Huynh N. T., Ilyinskii P. O., Ingale S., Irvine D. J., Ishii M., Iwasaki A., Iwasaki A., Iwasaki A., Jain S., Jain S., Janeway C. A., Jewell C. M., Jin B., Joffre O. P., Jones M.-C., Junt T., Kamaly N., Kaminskas L. M., Kasturi S. P., Kavya Rakhra, Kawai T., Keller S., Kim Y.-M., Kinman L., Kitaoka M., Klavinskis L. S., Klebanoff C. A., Kolaczkowska E., Kool M., Kourtis I. C., Kovacsovics-Bankowski M., Kovacsovics-Bankowski M., Kuo-Haller P., Kuznetsov V. A., Kwong B., Kwong B., Lai S. K., Lanzavecchia A., Laroui H., Lee I. H., Leonard J. P., Leuschner F., Li A. V., Li A. V., Li H., Li N., Li P., Lico C., Liu H., Liu Z., Locke L. W., Look M., Look M., Lv H., Mabbott N. A., Macho Fernandez E., Maeda H., Maier T., Maisel K., Maldonado R. a., Mandraju R., Manolova V., Martinez F. O., Matzinger P., Matzinger P., Maus M. V., Mbow M. L., McKee A. S., McNamara J. O., Melissa C. Hanson, Mellman I., Mellman I., Minguet S., Minguet S., Mishra D., Mittal A., Modery-Pawlowski C. L., Moghimi S. M., Mohri K., Moon J. J., Moon J. J., Moon J. J., Morefield G. L., Movahedi K., Moyano D. F., Moyle P. M., Mueller S. N., Mukai Y., Muraoka D., Murray P. J., Nakamura T., Nakamura T., Napolitani G., Nehaus V., Nembrini C., Ni X., Niikura K., Niu L., Nochi T., Nordly P., Ochiel D. O., Okada E., Okazaki T., Oussoren C., Oyewumi M. O., Panelli M. C., Panzarini E., Park J., Park J., Pasare C., Perica K., Perisé-Barrios A. J., Petersen L. K., Phan T. G., Pinheiro M., Plapied L., Ralli-Jain P., Rancan F., Rappuoli R., Ravindran R., Reddy S. T., Reddy S. T., Reis e Sousa C., Restifo N. P., Riese P., Rodríguez-Limas W. a., Rosalia R. A., Rosalia R. A., Russell D. G., Sah H., Salata O., Salman H. H., Saluja S. S., Sanders M. T., Sarma J. V., Sawaengsak C., Scheerlinck J.-P. Y., Schietinger A., Seong S.-Y., Serramía M. J., Sharp F. a, Shen H., Sheridan B. S., Shi C., Shima F., Silva A. L., Slütter B., Slütter B., Smirnov D., Smith B. R., Smith B. R., Smith D. M., Sneh-Edri H., Snyder A., Soboll G., Sokolova V., Solbrig C. M., St. John A. L., Stano A., Stano A., Stano A., Stefanick J. F., Stefanick J. F., Steinman R. M., Stephan M. T., Stephan M. T., Stylianou E., Sun B., Tacken P. J., Takano S., Talar Tokatlian, Tanaka Y., Taneichi M., Tang R., Temchura V. V., Thomas S. N., Thornton E. E., Tobio M., Tomita Y., Topalian S. L., Torres A. G., Tsai S., Tsai S., Tsai S., Tsuji K., Turley D. M., Ulery B. D., Vajdy M., Van der Vlies A. J., Van Lehn R. C., Van ’t Klooster G., Vanlandschoot P., Vicente S., Villa C. H., Vinay D. S., Waeckerle-Men Y., Waeckerle-Men Y., Walter S., Wang C., Wang T., Wang Y.-Y., Wang Z., Watson D. S., Weber J., Wijagkanalan W., Williams G. R., Wilson J. T., Wira C. R., Woodrow K. a., Wright H. L., Wu T. Y., Xia Y., Xiao Y., Xing Y., Xu J., Xu L., Xu Q.-H., Yan S., Yates R. M., Yeaman G. R., Yee C., Yeh T.-H., Yeste a., Yu S. S., Yuan H., Yuba E., Yuba E., Zeltins A., Zeng R., Zhang S., Zhang Z., Zheng Y., Zhu Q., Zhu Q., Zoete M. R. De   +356 more
core   +6 more sources

Synthetic carbohydrate-based vaccines: challenges and opportunities

Journal of Biomedical Science, 2020
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial ...
Ravinder Mettu, Chiang-Yun Chen, Chung-Yi Wu   +2 more
doaj   +2 more sources

Synthetic Messenger RNA-Based Vaccines: From Scorn to Hype

Viruses, 2021
In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are
Steve Pascolo
doaj   +2 more sources

Synthetic peptide vaccines

Вопросы вирусологии, 2016
An update on the development and trials of synthetic peptide vaccines is reviewed. The review considers the successful examples of specific protection as a result of immunization with synthetic peptides using various protocols.
O. V. Sergeyev, I. F. Barinsky
doaj   +3 more sources

Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines

Frontiers in Chemistry, 2015
Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
Richard James Payne, David M McDonald, Scott N Byrne   +2 more
doaj   +2 more sources

Approaches to Improve Chemically Defined Synthetic Peptide Vaccines

Frontiers in Immunology, 2018
Progress made in peptide-based vaccinations to induce T-cell-dependent immune responses against cancer has invigorated the search for optimal vaccine modalities.
Brett J. Hos, Elena Tondini, Sander I. van Kasteren, Ferry Ossendorp   +3 more
doaj   +2 more sources

Designing synthetic vaccines for HIV [PDF]

Expert Review of Vaccines, 2015
Despite three decades of intensive research efforts, the development of an effective prophylactic vaccine against HIV remains an unrealized goal in the global campaign to contain the HIV/AIDS pandemic. Recent characterization of novel epitopes for inducing broadly neutralizing antibodies has fueled research in the design and synthesis of new, well ...
Alberto Fernández-Tejada, Barton F Haynes, Samuel J Danishefsky   +2 more
openaire   +3 more sources

Peptide-based synthetic vaccines

Chemical Science, 2016
This review summarise the current stand and future perspective on synthetic peptide-based vaccines.
Skwarczynski, Mariusz, Toth, Istvan
openaire   +5 more sources

Harnessing synthetic biology for advancing RNA therapeutics and vaccine design

npj Systems Biology and Applications, 2023
Recent global events have drawn into focus the diversity of options for combatting disease across a spectrum of prophylactic and therapeutic approaches. The recent success of the mRNA-based COVID-19 vaccines has paved the way for RNA-based treatments to ...
Blaine A. Pfeifer, Marie Beitelshees, Andrew Hill, Justin Bassett, Charles H. Jones   +4 more
doaj   +2 more sources

PEGylated CuInS2/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75NTR/MAPK pathway

Ecotoxicology and Environmental Safety, 2021
The widespread application of cadmium-free CuInS2/ZnS QDs has raised great concern regarding their potential toxicity to humans. To date, toxicological data related to CuInS2/ZnS QDs are scarce.
Zhiwen Yang, Wenyi Zou, Yongning Pan, Ken-Tye Yong, Li Li, Xiaomei Wang, Dongmeng Liu, Tingting Chen, Dahui Xue, Guimiao Lin   +9 more
doaj   +1 more source