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Synthetic peptide vaccines

Вопросы вирусологии, 2016
An update on the development and trials of synthetic peptide vaccines is reviewed. The review considers the successful examples of specific protection as a result of immunization with synthetic peptides using various protocols.
O. V. Sergeyev, I. F. Barinsky
doaj   +3 more sources

Broadly Neutralizing Synthetic Cannabinoid Vaccines [PDF]

JACS Au, 2020
Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming a major public health risk. Due to the wide variety of SCs, broadly neutralizing antibodies generated by active immunization present an intriguing pathway to combat cannabinoid use disorder.
Mingliang Lin, Jinny Claire Lee, Steven Blake, Beverly Ellis, Lisa M. Eubanks, Kim D. Janda   +5 more
doaj   +3 more sources

Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines [PDF]

Frontiers in Chemistry, 2015
Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
Richard James Payne, David M McDonald, Scott N Byrne   +2 more
doaj   +3 more sources

Novel enzymatic DNA produced from a text file achieves comparable immune responses as plasmid vaccine [PDF]

npj Vaccines
DNA vaccines have garnered considerable attention due to their recent success in humans for SARS-CoV-2 and immunotherapy for cancer. However, conventional methods for creating and manufacturing DNA vaccines at-scale are slow and rate-limiting for timely ...
James Fuller, Erik Kvam, Sandrine Creton, Courtney Hall, Nicholas J. Tursi, Kerry Blatney, Rebecca Ryan, Xavier Godron, David B. Weiner, Winston Timp, Weston Griffin, John Nelson, Deborah H. Fuller   +12 more
doaj   +2 more sources

PEGylated CuInS2/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75NTR/MAPK pathway

Ecotoxicology and Environmental Safety, 2021
The widespread application of cadmium-free CuInS2/ZnS QDs has raised great concern regarding their potential toxicity to humans. To date, toxicological data related to CuInS2/ZnS QDs are scarce.
Zhiwen Yang, Wenyi Zou, Yongning Pan, Ken-Tye Yong, Li Li, Xiaomei Wang, Dongmeng Liu, Tingting Chen, Dahui Xue, Guimiao Lin   +9 more
doaj   +1 more source

Systematic evaluation of CdSe/ZnS quantum dots toxicity on the reproduction and offspring health in male BALB/c mice

Ecotoxicology and Environmental Safety, 2021
Increased applications of quantum dots (QDs) in the biomedical field have aroused attention for their potential toxicological effects. Although numerous studies have been carried out on the toxicity of QDs, their effects on reproductive and development ...
Li Li, Xiaotan Lin, Tingting Chen, Kan Liu, Yajing Chen, Zhiwen Yang, Dongmeng Liu, Gaixia Xu, Xiaomei Wang, Guimiao Lin   +9 more
doaj   +1 more source

Chemical and Synthetic Biology Approaches for Cancer Vaccine Development

Molecules, 2022
Cancer vaccines have been considered promising therapeutic strategies and are often constructed from whole cells, attenuated pathogens, carbohydrates, peptides, nucleic acids, etc.
Farzana Hossain, Shruthi Kandalai, Xiaozhuang Zhou, Nan Zhang, Qingfei Zheng   +4 more
doaj   +1 more source

Synthetic peptide vaccines [PDF]

Biomeditsinskaya Khimiya, 2010
This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections.
Moisa, Alexandr A., Kolesanova, Ekaterina F.   +1 more
openaire   +6 more sources

Cytotoxicity and Immune Dysfunction of Dendritic Cells Caused by Graphene Oxide

Frontiers in Pharmacology, 2020
Graphene, known as “black gold”, has important applications in various fields. In previous studies, it has been proved that graphene oxide (GO) which is a derivative of graphene has low toxicity.
Zhiwen Yang, Yongning Pan, Tingting Chen, Li Li, Wenyi Zou, Dongmeng Liu, Dahui Xue, Xiaomei Wang, Guimiao Lin   +8 more
doaj   +1 more source

Vaccine Technologies and Platforms for Infectious Diseases: Current Progress, Challenges, and Opportunities

Vaccines, 2021
Vaccination is a key component of public health policy with demonstrated cost-effective benefits in protecting both human and animal populations. Vaccines can be manufactured under multiple forms including, inactivated (killed), toxoid, live attenuated ...
Majed Ghattas, Garima Dwivedi, Marc Lavertu, Mohamad-Gabriel Alameh   +3 more
doaj   +1 more source