Results 11 to 20 of about 1,877,160 (342)

Synthetic Glycans to Improve Current Glycoconjugate Vaccines and Fight Antimicrobial Resistance

Chemical Reviews, 2022
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile, Escherichia coli, Enterococcus faecium, Klebsiella pneumoniae, Neisseria ...
Linda Del Bino, K. E. Østerlid, Dung-Yeh Wu, Francesca Nonne, M. Romano, J. Codée, R. Adamo   +6 more
semanticscholar   +1 more source

mRNA vaccines: the most recent clinical applications of synthetic mRNA

Archives of pharmacal research, 2022
Synthetic mRNA has been considered as an emerging biotherapeutic agent for the past decades. Recently, the SARS-CoV-2 pandemic has led to the first clinical use of synthetic mRNA.
Su-Mi Kwon, Minseo Kwon, Seongeun Im, Kyuri Lee, Hyukjin Lee   +4 more
semanticscholar   +1 more source

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Chemical Reviews, 2021
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
semanticscholar   +1 more source

Systematic evaluation of CdSe/ZnS quantum dots toxicity on the reproduction and offspring health in male BALB/c mice

Ecotoxicology and Environmental Safety, 2021
Increased applications of quantum dots (QDs) in the biomedical field have aroused attention for their potential toxicological effects. Although numerous studies have been carried out on the toxicity of QDs, their effects on reproductive and development ...
Li Li, Xiaotan Lin, Tingting Chen, Kan Liu, Yajing Chen, Zhiwen Yang, Dongmeng Liu, Gaixia Xu, Xiaomei Wang, Guimiao Lin   +9 more
doaj   +1 more source

Synthetic protein conjugate vaccines provide protection against Mycobacterium tuberculosis in mice

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Tuberculosis is the leading cause of death worldwide from a single infectious agent, but vaccines developed to date have limited efficacy and pose safety concerns.
C. Hanna, Anneliese S. Ashhurst, D. Quan, J. Maxwell, W. Britton, R. Payne   +5 more
semanticscholar   +1 more source

The Development of Vaccines from Synthetic Tumor‐Associated Mucin Glycopeptides and their Glycosylation‐Dependent Immune Response

The chemical record, 2021
Tumor‐associated carbohydrate antigens are overexpressed as altered‐self in most common epithelial cancers. Their glycosylation patterns differ from those of healthy cells, functioning as an ID for cancer cells.
N. Stergiou, Moritz Urschbach, A. Gabba, E. Schmitt, H. Kunz, Pol Besenius   +5 more
semanticscholar   +1 more source

Chemical and Synthetic Biology Approaches for Cancer Vaccine Development

Molecules, 2022
Cancer vaccines have been considered promising therapeutic strategies and are often constructed from whole cells, attenuated pathogens, carbohydrates, peptides, nucleic acids, etc.
Farzana Hossain, Shruthi Kandalai, Xiaozhuang Zhou, Nan Zhang, Qingfei Zheng   +4 more
doaj   +1 more source

Synthetic peptide vaccines [PDF]

Biomeditsinskaya Khimiya, 2010
This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections.
Moisa, Alexandr A., Kolesanova, Ekaterina F.   +1 more
openaire   +6 more sources

Cytotoxicity and Immune Dysfunction of Dendritic Cells Caused by Graphene Oxide

Frontiers in Pharmacology, 2020
Graphene, known as “black gold”, has important applications in various fields. In previous studies, it has been proved that graphene oxide (GO) which is a derivative of graphene has low toxicity.
Zhiwen Yang, Yongning Pan, Tingting Chen, Li Li, Wenyi Zou, Dongmeng Liu, Dahui Xue, Xiaomei Wang, Guimiao Lin   +8 more
doaj   +1 more source

Vaccine Technologies and Platforms for Infectious Diseases: Current Progress, Challenges, and Opportunities

Vaccines, 2021
Vaccination is a key component of public health policy with demonstrated cost-effective benefits in protecting both human and animal populations. Vaccines can be manufactured under multiple forms including, inactivated (killed), toxoid, live attenuated ...
Majed Ghattas, Garima Dwivedi, Marc Lavertu, Mohamad-Gabriel Alameh   +3 more
doaj   +1 more source