Results 31 to 40 of about 155,755 (365)

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering

open access: yesChemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022
Structural and biochemical data demonstrate that 4‐phenylbenzoic acid binds within the active site of the cytochrome P450 monooxygenase CYP199A4, but no oxidation occurs. Protein engineering and molecular dynamic simulations establish that aromatic oxidation is enabled by a subtle shift of the substrate relative to the heme, thus improving our ...
Tom Coleman   +9 more
wiley   +1 more source

Influence of Valine Analogues on Protein Synthesis of Chicken Embryo Myoblasts

open access: yesThe Journal of Poultry Science, 2014
The influence of various valine analogues on protein synthesis of chicken embryo myoblasts was examined. Valine and its analogues (D-valine, methylvaline, valinol) were supplemented into Medium 199 containing 20 ng/ml of chicken insulin-like growth ...
Kazumi Kita, Ryosuke Makino
doaj   +1 more source

Interference-Normalised Least Mean Square Algorithm [PDF]

open access: yesIEEE Signal Processing Letters, Vol. 14, No 12, pp. 988-991, 2007, 2016
An interference-normalised least mean square (INLMS) algorithm for robust adaptive filtering is proposed. The INLMS algorithm extends the gradient-adaptive learning rate approach to the case where the signals are non-stationary. In particular, we show that the INLMS algorithm can work even for highly non-stationary interference signals, where previous ...
arxiv   +1 more source

The Uptake and Release of Amino Acids by Staphylococcus aureus at Mid-Exponential and Stationary Phases and Their Corresponding Responses to Changes in Temperature, pH and Osmolality

open access: yesFrontiers in Microbiology, 2020
Staphylococcus aureus is an important pathogen that is associated with nosocomial infections, as well as food poisoning. This bacterium is resistant to antimicrobial agents and can survive in a wide range of environmental conditions.
Mousa M. Alreshidi   +4 more
doaj   +1 more source

Investigating the causal association between branched-chain amino acids and Alzheimer's disease: A bidirectional Mendelian randomized study

open access: yesFrontiers in Nutrition, 2023
BackgroundThere are many metabolic pathway abnormalities in Alzheimer's disease (AD). Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with AD but have not obtained consistent results.
Xiao-hang Qian   +10 more
doaj   +1 more source

Bandwidth Extension of Narrowband Speech for Low Bit-Rate Wideband Coding [PDF]

open access: yesProc. IEEE Speech Coding Workshop (SCW), 2000, pp. 130-132, 2016
Wireless telephone speech is usually limited to the 300-3400 Hz band, which reduces its quality. There is thus a growing demand for wideband speech systems that transmit from 50 Hz to 8000 Hz. This paper presents an algorithm to generate wideband speech from narrowband speech using as low as 500 bits/s of side information.
arxiv   +1 more source

Branched-chain amino acids linked to depression in young adults

open access: yesFrontiers in Neuroscience, 2022
Depression is a heterogeneous mental health problem affecting millions worldwide, but a majority of individuals with depression do not experience relief from initial treatments. Therefore, we need to improve our understanding of the biology of depression.
Alyce M. Whipp   +7 more
doaj   +1 more source

Perceptually-Motivated Nonlinear Channel Decorrelation For Stereo Acoustic Echo Cancellation [PDF]

open access: yesProceedings of Joint Workshop on Hands-free Speech Communication and Microphone Arrays (HSCMA), pp. 188-191, 2008, 2016
Acoustic echo cancellation with stereo signals is generally an under-determined problem because of the high coherence between the left and right channels. In this paper, we present a novel method of significantly reducing inter-channel coherence without affecting the audio quality.
arxiv   +1 more source

Valine increases milk fat synthesis in mammary gland of gilts through stimulating AKT/MTOR/SREBP1 pathway†

open access: yesBiology of Reproduction, 2019
Lactating mammary glands are among the most active lipogenic organs and provide a large percentage of bioactive lipids and calories for infant growth.
Long Che   +9 more
semanticscholar   +1 more source

Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer

open access: yesCell Death and Disease, 2019
Valine catabolism is known to be essential for cancer cells but the detailed mechanism remains unclear. This study is to explore the critical roles of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) in colorectal cancers (CRC) and to develop a new therapy ...
Yun-long Shan   +11 more
semanticscholar   +1 more source

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