Results 41 to 50 of about 138,081 (263)

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients

Biomolecules, 2023
Considering the relationship between disease severity and the extent of metabolic derangement in heart failure, we hypothesized that the serum levels of metabolites may have prognostic value for 1-year mortality in acute heart failure (AHF).
Iva Klobučar, Luka Vidović, Ilona Arih, Margarete Lechleitner, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl, Saša Frank, Vesna Degoricija   +9 more
doaj   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Systemic energy metabolism changes in patients with heart failure receiving specific oral nutritional supplements in combination with Mediterranean diet

Frontiers in Nutrition
BackgroundHeart failure (HF) is associated with disease-related malnutrition, all of which contribute to impaired functional capacity and adverse outcomes.
Aura D. Herrera-Martínez, Aura D. Herrera-Martínez, Concepción Muñoz Jiménez, Concepción Muñoz Jiménez, José López Aguilera, José López Aguilera, Manuel Crespin, Manuel Crespin, María Ángeles Gálvez Moreno, María Ángeles Gálvez Moreno, María José Molina Puerta, María José Molina Puerta   +11 more
doaj   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Gustatory sensitivity to amino acids in bumblebee mouthparts

Royal Society Open Science
Bees rely on amino acids from nectar and pollen for essential physiological functions. While nectar typically contains low (less than 1 mM) amino acid concentrations, levels in pollen are higher but variable (10–200 mM).
Sergio Rossoni, Rachel H. Parkinson, Jeremy E. Niven, Elizabeth Nicholls   +3 more
doaj   +1 more source

Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?

Journal of the International Society of Sports Nutrition, 2017
The branched chain amino acids (BCAAs) are leucine, valine and isoleucine. A multi-million dollar industry of nutritional supplements has grown around the concept that dietary supplements of BCAAs alone produce an anabolic response in humans driven by a ...
Robert R. Wolfe
doaj   +1 more source

Interaction and imbalance between indispensable amino acids in young piglets

Animal, 2019
Lowering protein level in diets for piglets urge to have knowledge on the piglet’s requirements for essential amino acids (AA) and their interactions. The present studies aimed to determine the interaction between the dietary level of valine (Val) and ...
A.J.M. Jansman, O. Cirot, E. Corrent, W. Lambert, J. Ensink, J.Th.M. van Diepen   +5 more
doaj   +1 more source

Cyclo(valine–valine) inhibits Vibrio cholerae virulence gene expression

Microbiology, 2014
Vibrio cholerae has been shown to produce a cyclic dipeptide, cyclo(phenylalanine–proline) (cFP), that functions to repress virulence factor production. The objective of this study was to determine if heterologous cyclic dipeptides could repress V. cholerae virulence factor production.
Amit, Vikram, Vanessa M, Ante, X Renee, Bina, Qin, Zhu, Xinyu, Liu, James E, Bina   +5 more
openaire   +2 more sources