Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. [PDF]
PLoS ONE, 2010 Trypanosoma brucei does not respond transcriptionally to several endoplasmic reticulum (ER) stress conditions, including tunicamycin or dithiothreitol, indicating the absence of a conventional unfolded protein response. This suggests divergent mechanisms
Mark C Field +4 more
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Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing [PDF]
mSphere, 2022 African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant surface glycoprotein (VSG).
Mohamed Sharif +3 more
doaj +2 more sources
Turnover of Variant Surface Glycoprotein in
mBio, 2021 African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (
Paige Garrison +9 more
doaj +2 more sources
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex [PDF]
Nature Communications, 2019 Monoallelic expression of variant surface glycoprotein genes (VSGs) is essential for immune evasion by Trypanosoma brucei. Here, Faria et al. show that the VEX protein complex controls VSG allelic exclusion, and that CAF‐1 sustains inheritance of the VEX‐
Joana Faria +5 more
doaj +2 more sources
Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei [PDF]
mBio, 2022 In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin +3 more
doaj +2 more sources
Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation [PDF]
Nature Communications, 2017 Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a ...
Jason Pinger +2 more
doaj +2 more sources
SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes. [PDF]
EMBO Rep, 2019 SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The presence of a highly SUMOylated focus associated with the nuclear body, where the VSG gene is transcribed, further suggests an important role of SUMOylation in regulating VSG expression.
Saura A +10 more
europepmc +6 more sources
Trypanosoma Variant Surface Glycoprotein: A Review
مجلة الانبار للعلوم البيطريةThe glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
doaj +2 more sources
The release of host-derived antibodies bound to the variant surface glycoprotein (VSG) of Trypanosoma brucei cannot be explained by pH-dependent conformational changes of the VSG dimer [version 1; peer review: 2 approved] [PDF]
Open Research EuropeBackground Trypanosoma brucei is a protozoan parasite that evades the mammalian host’s adaptive immune response by antigenic variation of the highly immunogenic variant surface glycoprotein (VSG).
Pavel Nesterov +8 more
doaj +2 more sources
Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei [PDF]
FASEB BioAdvances, 2019 Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated through endocytosis and the suramin receptor in trypanosomes
Natalie Wiedemar +5 more
doaj +2 more sources