Results 31 to 40 of about 60,096 (254)

New Trypanosoma evansi Type B Isolates from Ethiopian Dromedary Camels. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Trypanosoma (T.) evansi is a dyskinetoplastic variant of T. brucei that has gained the ability to be transmitted by all sorts of biting flies. T. evansi can be divided into type A, which is the most abundant and found in Africa, Asia and Latin
Hadush Birhanu, Tadesse Gebrehiwot, Bruno Maria Goddeeris, Philippe Büscher, Nick Van Reet   +4 more
doaj   +1 more source

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes

Frontiers in Cell and Developmental Biology, 2022
The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack.
James Budzak, Gloria Rudenko
doaj   +1 more source

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific

BMC Genomics, 2007
Background In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low ...
Sharma Reuben, Mott Helen, Jones Nicola G, Picozzi Kim, Hutchinson O Clyde, Welburn Susan C, Carrington Mark   +6 more
doaj   +1 more source

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei. [PDF]

PLoS Pathogens, 2005
Trypanosoma brucei, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite, with GPEET ...
Simon Urwyler, Erik Vassella, Jan Van Den Abbeele, Christina Kunz Renggli, Pat Blundell, J David Barry, Isabel Roditi   +6 more
doaj   +2 more sources

Transmembrane and truncated (SEC) isoforms of MUC1 in the human endometrium and Fallopian tube

Reproductive Biology and Endocrinology, 2003
The cell surface mucin MUC1 is expressed by endometrial epithelial cells with increased abundance in the secretory phase of the menstrual cycle, when it is found both at the apical cell surface and in secretions.
Wreschner Daniel H, Smorodinsky Nechama I, Simón Carlos, Meseguer Marcos, Hey Neil A, Ortíz María, Aplin John D   +6 more
doaj   +1 more source

Structural Studies of Variant Surface Glycoproteins on the Trypanosoma Surface

, 2021
Trypanosoma parasites are the pathogenic agent causing human and animal African Trypanosomiasis. The parasites undergo a process called antigenic variation, which allows them to perpetually evade the host immune response. Trypanosomes are coated almost uniformly with a single protein, the Variant Surface Glycoprotein (VSG).
openaire   +2 more sources

Myristate exchange on the Trypanosoma brucei variant surface glycoprotein. [PDF]

Proceedings of the National Academy of Sciences, 1996
The glycosyl-phosphatidylinositol (GPI) anchor of the Trypanosoma brucei variant surface glycoprotein (VSG) is unique in having exclusively myristate as its fatty acid component. We previously demonstrated that the myristate specificity is the result of two independent pathways.
L U, Buxbaum, K G, Milne, K A, Werbovetz, P T, Englund   +3 more
openaire   +2 more sources

An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids

Microbial Cell, 2014
African trypanosomes are evolutionarily highly divergent parasitic protozoa, and as a consequence the vast majority of trypanosome membrane proteins remain uncharacterised in terms of location, trafficking or function.
Harriet Allison, Amanda J. O’Reilly, Jeremy Sternberg, Mark C. Field   +3 more
doaj   +1 more source

Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei.

PLoS Pathogens, 2012
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane anchor and eight potential N ...
Angela Mehlert, Mark R Wormald, Michael A J Ferguson   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source