Results 11 to 20 of about 22,016 (234)

VDAC Genes Expression and Regulation in Mammals [PDF]

Frontiers in Physiology, 2021
VDACs are pore-forming proteins, coating the mitochondrial outer membrane, and playing the role of main regulators for metabolites exchange between cytosol and mitochondria. In mammals, three isoforms have evolutionary originated, VDAC1, VDAC2, and VDAC3.
Federica Zinghirino, Xena Giada Pappalardo, Angela Messina, Angela Messina, Giuseppe Nicosia, Vito De Pinto, Vito De Pinto, Vito De Pinto, Francesca Guarino, Francesca Guarino, Francesca Guarino   +10 more
doaj   +4 more sources

VDAC in Retinal Health and Disease

Biomolecules
The retina, a tissue of the central nervous system, is vital for vision as its photoreceptors capture light and transform it into electrical signals, which are further processed before they are sent to the brain to be interpreted as images. The retina is
Ying Xu, Shanti R. Tummala, Xiongmin Chen, Noga Vardi   +3 more
doaj   +3 more sources

VDAC—A Primal Perspective [PDF]

International Journal of Molecular Sciences, 2021
The evolution of the eukaryotic cell from the primal endosymbiotic event involved a complex series of adaptations driven primarily by energy optimization. Transfer of genes from endosymbiont to host and concomitant expansion (by infolding) of the endosymbiont’s chemiosmotic membrane greatly increased output of adenosine triphosphate (ATP) and placed ...
openaire   +2 more sources

VDAC Channels [PDF]

IUBMB Life, 2001
AbstractTrafficking of metabolites across the outer mitochondrial membrane is believed to be mediated primarily by the pore‐forming voltage‐dependent anion channel, VDAC (also known as mitochondrial porin). An expanding body of in vitro studies have strongly suggest that the pore formed by VDAC can be regulated in a number of ways that implicate it as ...
E, Blachly-Dyson, M, Forte
openaire   +2 more sources

A C-Terminally Truncated Variant of Neurospora crassa VDAC Assembles Into a Partially Functional Form in the Mitochondrial Outer Membrane and Forms Multimers in vitro

Frontiers in Physiology, 2021
The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Previously,
Fraser G. Ferens, Fraser G. Ferens, William A. T. Summers, Ameet Bharaj, Jörg Stetefeld, Deborah A. Court   +5 more
doaj   +1 more source

VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges

Frontiers in Physiology, 2021
Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate (ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the cytosol, cross the outer mitochondrial membrane (OMM) through voltage ...
Kareem A. Heslop, Veronica Milesi, Eduardo N. Maldonado, Eduardo N. Maldonado   +3 more
doaj   +1 more source

Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior [PDF]

, 2012
Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Anastasia Salisowski, Barbara Mertins, Georgios Psakis, Katrin Christiane Back, Lars-Oliver Essen, Philipp Reiss, Ulrich Koert, Wolfgang Grosse, Zhe Zhang   +8 more
core   +8 more sources

The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration

Frontiers in Physiology, 2021
Voltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore.
Anasuya Moitra, Doron Rapaport
doaj   +1 more source

Using VDAC-Tubulin Interaction to Assess VDAC Orientation in the Mitochondrial Membrane [PDF]

Biophysical Journal, 2010
Recently we have found that dimeric αβ-tubulin at nanomolar concentrations induces reversible partial blockage of VDAC channel, reconstituted into a planar lipid membrane (Rostovtseva et al., PNAS 2008). Tubulin induces characteristic, well resolved fast blocking events with the highly voltage-dependent binding parameters. Tubulin interaction with VDAC
Rostovtseva, Tatiana K., Sheldon, Kely, Bezrukov, Sergey M.   +2 more
openaire   +1 more source

Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility

Cellular Physiology and Biochemistry, 2014
Background: Voltage-dependent anion channel (VDAC), a channel protein, exists in the outer mitochondrial membrane of somatic cells and is involved in multiple physiological and pathophysiological processes.
Bianjiang Liu, Min Tang, Zhijian Han, Jie Li, Jiexiu Zhang, Pei Lu, Ninghong Song, Zengjun Wang, Changjun Yin, Wei Zhang   +9 more
doaj   +1 more source