Results 21 to 30 of about 22,016 (234)

Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. [PDF]

PLoS ONE, 2011
The voltage-dependent anion channel (VDAC) forms the major pore in the outer mitochondrial membrane. Its high conducting open state features a moderate anion selectivity.
Eva-Maria Krammer, Fabrice Homblé, Martine Prévost   +2 more
doaj   +1 more source

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
Aghazadeh, Aghazadeh, Alho, Amitani, Anholt, Anholt, Anholt, Anholt, Antkiewicz-Michaluk, Arbo, Banati, Banati, Bar-Ami, Barron, Basile, Batarseh, Batarseh, Batarseh, Batarseh, Batra, Beinlich, Benavides, Bernassau, Besman, Bird, Bitran, Bose, Boujrad, Boujrad, Braestrup, Bribes, Bribes, Brunette, Cagnin, Campanella, Campioli, Casellas, Chauveau, Chen, Chen, Cho, Clark, Colasanti, Corcia, Costa, Costa, Costa, Cuhlmann, Daugherty, De Souza, Decaudin, Decker, Delavoie, Delerive, Doperalski, Enders, Epstein, Fafalios, Fan, Fan, Fan, Fur, Fur, Galiegue, Gastaldello, Gatliff, Gatliff, Gavish, Gavish, Gazouli, Gehlert, Gerhard, Gervois, Giatti, Giatzakis, Giatzakis, Golani, Gonzalez-Polo, Guillon, Gulyas, Guo, Guo, Gut, Hardwick, Hardwick, Hauet, Hauet, Jamin, Jaremko, Jaremko, Jemma Gatliff, Joo, Joseph-Liauzun, Karlstetter, Kita, Kondo, Konigsrainer, Korkhov, Kreisl, Kruczek, Kumar, Lacapere, Lacapere, Lavisse, Li, Li, Li, Li, Li, Li, Libby, Liu, Liu, Maia, Maury, Mazurika, McEnery, Miao, Michelangelo Campanella, Midzak, Midzak, Miettinen, Miller, Mills, Mizrahi, Morohaku, Murail, Nagler, Obame, Oberto, Olson, Ostuni, Ouchi, Owen, Owen, Owen, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Paradis, Pastorino, Pelechano, Petrescu, Poynter, Raghavan, Rey, Romeo, Rone, Rosenberg, Rosenberg, Rosenberg, Rupprecht, Rupprecht, Scarf, Schaller, Selvaraj, Shoukrun, Sileikyte, Soustiel, Sutter, Tang, Taylor, Teboul, Thompson, Trincavelli, Tu, Tu, Tu, Vanhee, Varrone, Vega, Verma, Wang, Wang, Wei, Whalin, Xiao, Yang, Yang, Yasuno, Yeliseev, Yoder, Zhang, Zhang, Zhao, Zhou   +189 more
core   +1 more source

Markov chain Monte Carlo based analysis of post-translationally modified VDAC1 gating kinetics

Frontiers in Physiology, 2015
The voltage-dependent anion channel (VDAC) is the main conduit for permeation of solutes (including nucleotides and metabolites) of up to 5 kDa across the mitochondrial outer membrane (MOM). Recent studies suggest that VDAC activity is regulated via post-
Shivendra eTewari, Yifan eZhou, Bradley eOtto, Ranjan K. Dash, Wai-Meng eKwok, Daniel eBeard   +5 more
doaj   +1 more source

Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs

Frontiers in Physiology, 2020
There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these hydrophobic compounds interact with the Voltage Dependent Anion Channel (VDAC).
Tatiana K. Rostovtseva, María Queralt-Martín, William M. Rosencrans, Sergey M. Bezrukov   +3 more
doaj   +1 more source

Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. [PDF]

PLoS ONE, 2011
Tubulin was recently found to be a uniquely potent regulator of the voltage-dependent anion channel (VDAC), the most abundant channel of the mitochondrial outer membrane, which constitutes a major pathway for ATP/ADP and other metabolites across this ...
Kely L Sheldon, Eduardo N Maldonado, John J Lemasters, Tatiana K Rostovtseva, Sergey M Bezrukov   +4 more
doaj   +1 more source

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1 [PDF]

, 2017
Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell.
Abramson, Jeff, Bergdoll, Lucie, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F., Evers, Alex S., Janetka, James W., Krishnan, Kathiresan, Mydock-McGrane, Laurel, Whitelegge, Julian P.   +10 more
core   +3 more sources

Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca2+ Uptake

Frontiers in Physiology, 2021
Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, including ...
Hirohito Shimizu, Simon Huber, Adam D. Langenbacher, Lauren Crisman, Jie Huang, Kevin Wang, Fabiola Wilting, Thomas Gudermann, Thomas Gudermann, Johann Schredelseker, Johann Schredelseker, Jau-Nian Chen   +11 more
doaj   +1 more source

VDAC, The early days

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
VDAC is now universally accepted as the channel in the mitochondrial outer membrane responsible for metabolite flux in and out of mitochondria. Its discovery occurred over two independent lines of investigation in the 1970s and 80s. This retrospective article describes the history of VDAC's discovery and how these lines merged in a collaboration by the
Colombini, Marco, Mannella, Carmen A.
openaire   +2 more sources

Regulation of hexokinase binding to VDAC [PDF]

Journal of Bioenergetics and Biomembranes, 2008
Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by interacting with the outer membrane voltage-dependent anion channel (VDAC). This interaction results in a shift in the susceptibility of mitochondria to pro-apoptotic signals that are mediated through Bcl2-family proteins. The upregulation of hexokinase II expression in
John G, Pastorino, Jan B, Hoek
openaire   +2 more sources

Voltage-dependent anion channels mediated apoptosis in refractory epilepsy

Open Medicine, 2020
The purpose of this study was to investigate the role of voltage-dependent anion channel (VDAC) in mitochondria-mediated apoptosis of neurons in refractory epilepsy. Western blot analyses were carried out to detect the changes in cytochrome C, caspase 9,
Zhao Yan, Jiang Wen-Jing, Ma Lin, Lin Yan, Wang Xing-Bang   +4 more
doaj   +1 more source