Results 141 to 150 of about 21,287,561 (278)
, 2011 Supplementary Tables 1-3 from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR ...
Kirsty Ratcliffe (14981885) +19 more
core +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
Imaging Early-Stage Metastases Using an 18F-Labeled VEGFR-1-Specific Single Chain VEGF Mutant. [PDF]
Mol Imaging Biol, 2021 Mason CA +9 more
europepmc +1 more source
The FEBS Journal, EarlyView.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy. [PDF]
Mol Ther Methods Clin Dev, 2021 Bosco J +19 more
europepmc +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2015 摘 要： 【目的】 为了分析Ｄｌｌ４、 ＶＥＧＦＲ－１、 ＶＥＧＦＲ－２在视网膜新生血管中的表达，探讨Ｎｏｔｃｈ１－Ｄｌｌ４信号通路在氧诱导视网膜病小鼠新生血管形成中的作用。【方法】 选用鼠龄７ ｄ的 Ｃ５７ＢＬ／６Ｊ 新生鼠３０只，分成实验组和对照组。实验组１５只，在氧浓度为（７５±２）％的密闭容器中生长５ ｄ，回到室内正常空气中；对照组１５只，在室内正常空气中生长。两组各取产后７ ｄ（７ ｄ ｐｏｓｔ－ｐａｒｔｕｍ，ｐ７）、ｐ１２、ｐ１７新生鼠 ５只，摘除眼球，取视网膜提取ＲＮＡ，以ＲＴ－ＰＣＲ ...
doaj
Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, EarlyView.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source