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Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Frontiers in Immunology, 2020 The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
Thomas N Wight, Charles W Frevert
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Cell Reports, 2020 Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han +2 more
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Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]
PeerJBackground Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan +10 more
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Nature Communications, 2022 Ghorbani and colleagues describe versican-V1 as an inhibitor of remyelination using transgenic mice that illuminate new GFP + oligodendrocytes. Mechanisms of versican-V1 include the direct inhibition of oligodendrocytes, and elevating Th17 cells.
Samira Ghorbani +2 more
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Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia‐Induced Pulmonary Hypertension [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Hypoxia‐induced pulmonary hypertension (HPH) is a severe vascular disorder that is characterized by the involvement of endothelial‐to‐mesenchymal transition (EndMT) in its pathogenesis.
Jinyan Yu +10 more
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The Dual Role of ADAMTS1 in Cardiovascular Remodeling: Balancing Extracellular Matrix Homeostasis and Pathological States [PDF]
Journal of Cardiovascular Development and DiseaseExtracellular matrix metalloproteinase ADAMTS1 (adhesion metalloproteinase with thrombospondin-type domain 1) is a key regulator in cardiovascular remodeling with functional paradoxes.
Siqin Sheng, Shunrong Zhang
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Versican expression from lung fibroblasts suppresses pulmonary fibrosis [PDF]
Nature CommunicationsThe activation and accumulation of lung fibroblasts, leading to excessive ECM deposition, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis, a lethal and currently untreatable disease.
Paraskevi Kanellopoulou +20 more
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Matrix Biology Plus, 2023 Cardiac fibrosis is a central pathological feature in several cardiac diseases, but the underlying molecular players are insufficiently understood. The extracellular matrix proteoglycan versican is elevated in heart failure and suggested to be a target ...
Athiramol Sasi +13 more
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Respiratory Research, 2023 Background and aims This study aimed to investigate the expression of plasma versican and plasma exosomal versican in non-small cell lung cancer (NSCLC) and its correlation with clinicopathological features, and to evaluate its diagnostic performance in ...
Wenjing Chang +6 more
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Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts. [PDF]
PLoS ONE, 2015 Versican, a chondroitin sulphate proteoglycan, is one of the key components of the provisional extracellular matrix expressed after injury. The current study evaluated the hypothesis that a versican-rich matrix alters the phenotype of cultured ...
Jon M Carthy +6 more
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