Results 21 to 30 of about 8,038 (173)
Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages. [PDF]
PLoS ONE, 2015 Hypoxia is a hallmark of many pathological tissues. Macrophages accumulate in hypoxic sites and up-regulate a range of hypoxia-inducible genes. The matrix proteoglycan versican has been identified as one such gene, but the mechanisms responsible for ...
Fattah Sotoodehnejadnematalahi +5 more
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Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer
Frontiers in Oncology, 2021 A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome.
Priyanka Hirani +4 more
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Isolation and Purification of Versican and Analysis of Versican Proteolysis [PDF]
, 2014 Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its receptor CD44 and interactions of the versican C-terminal globular (G3) domain with a variety of extracellular matrix proteins, versican is a key component of well-defined ...
Day, A.J., Foulcer, S.J., Apte, S.S.
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TGF-β1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway
Cellular Physiology and Biochemistry, 2014 Background & Aims: TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells.
Fengfeng Li, Shaohua Li, Tao Cheng
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Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells. [PDF]
PLoS ONE, 2012 Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene, suggest that HA and ...
Kate E Keller +4 more
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Molecules, 2023 Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary.
Chiung-Hui Liu +8 more
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Versican: a novel modulator of hepatic fibrosis [PDF]
Laboratory Investigation, 2016 Little is known about the deposition and turnover of proteoglycans in liver fibrosis, despite their abundance in the extracellular matrix. Versican plays diverse roles in modulating cell behavior in other fibroproliferative diseases, but remains poorly described in the liver.
Terence N, Bukong +4 more
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Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy
Molecules, 2022 We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar +7 more
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Versican is differentially regulated in the adventitial and medial layers of human vein grafts.
PLoS ONE, 2018 Changes in extracellular matrix proteins may contribute significantly to the adaptation of vein grafts to the arterial circulation. We examined the production and distribution of versican and hyaluronan in intact human vein rings cultured ex vivo, veins ...
Richard D Kenagy +14 more
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Context-dependent bioactivity of versican fragments
Glycobiology, 2019 AbstractVersican (VCAN) proteolysis and the accumulation of VCAN fragments occur in many developmental and disease processes, affecting extracellular matrix (ECM) structure and cell phenotype. Little is known about the significance of proteolysis and the roles of fragments, or how this ECM remodeling affects the microenvironment and phenotype of ...
Katherine Payne, Timms +1 more
openaire +2 more sources