Results 71 to 80 of about 8,038 (173)

An Integrated Evaluation Framework for Adult Heart Regeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Myocardial infarction (MI) remains a primary global cause of mortality due to irreversible cardiomyocyte loss. While promoting endogenous regeneration offers a highly promising therapy, its validation is critically hindered by the lack of standardised, comprehensive methodologies for quantitative assessment.
Yixun Li, Xinchang Liu, Xianliang Zhou, Yu Nie, Jie Feng   +4 more
wiley   +1 more source

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.

PLoS ONE, 2014
BackgroundWe hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in ...
Maria Vistnes, Jan Magnus Aronsen, Ida G Lunde, Ivar Sjaastad, Cathrine R Carlson, Geir Christensen   +5 more
doaj   +1 more source

Associations of Adipocyte-derived Versican and Macrophage-derived Biglycan with Body Adipose Tissue and Hepatosteatosis in Obese Children

JCRPE
INTRODUCTION: In animal models of obesity, adipocyte-derived versican, and macrophage-derived biglycan play a crucial role in mediating adipose tissue inflammation.
Reyhan Deveci Sevim, Mustafa Gök, Özge Çevik, Ömer Erdoğan, Sebla Güneş, Tolga Ünüvar, Ahmet Anık   +6 more
doaj   +1 more source

Effects of Versican V0/V1 gene silencing on biological behaviors of mouse dental papilla cells [PDF]

Kouqiang yixue
Objective To investigate the effect of Versican V0/V1 on biological behaviors of mouse dental papilla cells (mDPCs). Methods mDPCs were isolated from C57BL/6J mice at embryonic day 16.5 (E16.5).
WU Jiayan, HUANG Haiyan, SONG Chenyu, JIANG Beizhan
doaj   +1 more source

Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA

International Journal of COPD, 2017
Lian Wu,1,2 Jing Zhang,3 Jie Ming Qu,4 Chun-xue Bai,3 Mervyn J Merrilees5 1Department of Community and Health Services, Unitec, 2Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand; 3Department of ...
Wu L, Zhang J, Qu JM, Bai CX, Merrilees MJ   +4 more
doaj  

Homozygous Recessive Versican Missense Variation Is Associated With Early Teeth Loss in a Pakistani Family

Frontiers in Genetics, 2019
Only a few genes involved in teeth development and morphology are known to be responsible for tooth abnormalities in Mendelian-inherited diseases. We studied an inbred family of Pakistani origin in which two first-cousin born brothers are affected by ...
Stefania Bigoni, Marcella Neri, Chiara Scotton, Roberto Farina, Patrizia Sabatelli, Chongyi Jiang, Jianguo Zhang, Maria Sofia Falzarano, Rachele Rossi, Davide Ognibene, Rita Selvatici, Francesca Gualandi, Dieter Bosshardt, Paolo Perri, Claudio Campa, Francesco Brancati, Francesco Brancati, Marco Salvatore, Maria Chiara De Stefano, Domenica Taruscio, Leonardo Trombelli, Mingyan Fang, Mingyan Fang, Alessandra Ferlini, Alessandra Ferlini   +24 more
doaj   +1 more source

Proteolytic Cleavage of Versican During Limb Joint Development [PDF]

The Anatomical Record, 2010
AbstractVersican is highly expressed in developing joint interzones during limb morphogenesis. This study was undertaken to examine whether proteolytic cleavage of versican occurs that could potentially impact its function during the process of embryonic synovial joint formation.
openaire   +2 more sources

The extracellular matrix in multiple sclerosis: an update

Brazilian Journal of Medical and Biological Research, 2001
Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell
R.A. Sobel
doaj   +1 more source

Interleukin-11 Promotes the Progress of Gastric Carcinoma via Abnormally Expressed Versican

International Journal of Biological Sciences, 2012
Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines.
Zhenwei Zhang, Jianpeng Zhang, Lei Miao, Ke Liu, Shengsheng Yang, Chuanyong Pan, Binghua Jiao
doaj  

Association of versican turnover with all-cause mortality in patients on haemodialysis.

PLoS ONE, 2014
ObjectiveCardiovascular diseases are among the most common causes of mortality in renal failure patients undergoing haemodialysis. A high turnover rate of the proteoglycan versican, represented by the increased presence of its fragmentation products in ...
Federica Genovese, Morten A Karsdal, Diana J Leeming, Alexandra Scholze, Martin Tepel   +4 more
doaj   +1 more source