Results 11 to 20 of about 6,573 (255)

Membrane Disruption by Very Long Chain Fatty Acids during Necroptosis

ACS Chemical Biology, 2019
Necroptosis is a form of regulated cell death which results in loss of plasma membrane integrity, release of intracellular contents, and an associated inflammatory response. We previously found that saturated very long chain fatty acids (VLCFAs), which contain ≥20 carbons, accumulate during necroptosis.
Laura R. Parisi, Shahin Sowlati-Hashjin, Ilyas A. Berhane, Samuel L. Galster, Kevin A. Carter, Jonathan F. Lovell, Sherry R. Chemler, Mikko Karttunen, G. Ekin Atilla-Gokcumen   +8 more
core   +6 more sources

Emerging roles of polyunsaturated fatty acid synthesis pathway in colorectal cancer

Animal Cells and Systems, 2023
The development of colorectal cancer typically involves the accumulated influences of genetic alterations, medical issues, lifestyle, and diet. Dietary fatty acids appear to affect the tumorigenesis and progression of colorectal cancer.
Young-Ah Moon
doaj   +1 more source

The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Agriculture, 2022
Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy.
Qinyue Lu, Weicheng Zong, Mingyixing Zhang, Zhi Chen, Zhangping Yang   +4 more
doaj   +1 more source

Peroxisomes attenuate cytotoxicity of very long-chain fatty acids

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2023
One of the major functions of peroxisomes in mammals is oxidation of very long-chain fatty acids (VLCFAs). Genetic defects in peroxisomal β-oxidation result in the accumulation of VLCFAs and lead to a variety of health problems, such as demyelination of nervous tissues.
Ali, Hanif, Kobayashi, Miyu, Morito, Katsuya, Hasi, Rumana Yesmin, Aihara, Mutsumi, Hayashi, Junji, Kawakami, Ryushi, Tsuchiya, Koichiro, Sango, Kazunori, Tanaka, Tamotsu   +9 more
openaire   +2 more sources

Genotoxicity evaluation of a fish oil concentrate containing Very Long Chain Fatty Acids

Toxicology Reports, 2023
Very long chain fatty acids (VLCFAs) are lipids found in fish with a chain length longer than C22. They represent a minor lipid fraction composing of less than 1% of the total lipid.
Derek Tobin, Harald Svensen, Iren Stoknes, Michael Dornish   +3 more
doaj   +1 more source

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology [PDF]

Biomolecules & Therapeutics, 2014
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators.
Sassa, Takayuki, Kihara, Akio
openaire   +2 more sources

Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA) [PDF]

, 2007
Considerable evidence exists for marked beneficial effects of omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy. The omega-3 LCPUFA docosahexaenoic acid (DHA) is incorporated in large amounts in fetal brain and other tissues ...
Hans Demmelmair, Elvira Larqué, Berthold Koletzko, Koletzko, Berthold, Larqué, Elvira, Demmelmair, Hans   +5 more
core   +1 more source

Inverse Association between trans Isomeric and Long-Chain Polyunsaturated Fatty Acids in Pregnant Women and Their Newborns: Data from Three European Countries [PDF]

, 2011
Background: trans unsaturated fatty acids are thought to interfere with essential fatty acid metabolism. To extend our knowledge of this phenomenon, we investigated the relationship between trans isomeric and long-chain polyunsaturated fatty acids ...
Krauss-Etschmann, S., É. Szabó, Marosvolgyi, Tamas, Campoy, C., T. Marosvölgyi, Decsi, Tamás, Marosvölgyi, T., C. Campoy, B. Koletzko, M. Escolano, Campoy, Cristina, Cruz, M., Szabó, É., Krauss-Etschmann, Susanne, S. Krauss-Etschmann, M. Cruz, Szabo, Eva, Escolano, M., Marchal, G., T. Decsi, Koletzko, Berthold, H. Demmelmair, Demmelmair, Hans, G. Marchal   +23 more
core   +1 more source

The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. [PDF]

, 2008
This paper reviews current knowledge on the role of the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, 20:4n-6), in maternal and term infant nutrition as well as infant development ...
Alexandre Lapillonne, Tamas Decsi, S. Forsyth, Niels J Secher, Berthold Koletzko, Willatts, Peter, MD Berthold Koletzko, C. Agostoni, Hansjosef Bö Hles, N. J. Secher, NN, NN, Szajewska, Hania, Lapillonne, Alexandre, Irene Cetin, Carlo Agostoni, Ricardo Uauy, Putet, Guy, Eric Lien, Forsyth, Stewart, I. Hoesli, Uauy, Ricardo, Mike Symonds, Dudenhausen, Joachim W, Uauy Dagach-Imbarack, Ricardo, Cristina Campoy, W. Holzgreve, Stewart Forsyth, Hania Szajewska, T. Decsi, Irene Hoesli, Koletzko, Berthold, Lien, Eric, J. W. Dudenhausen, Peter Willatts, Secher, Niels J, C. Campoy, Guy Putet, B. Koletzko, H. Szajewska, E. Lien, G. Putet, Joachim W Dudenhausen, Dudenhausen, Joachim W., Boehles, Hansjosef, Hoesli, Irene, Böhles, Hansjosef, Decsi, Tamas, Dupont, Cristophe, Cristophe Dupont, M. Symonds, Campoy, Cristina, Secher, Niels J., Symonds, Mike, P. Willatts, Cetin, Irene, A. Lapillonne, I. Cetin, Agostoni, Carlo, H. Böhles, Wolfgang Holzgreve, Holzgreve, Wolfgang, R. Uauy, World Association of Perinatal Medicine Dietary Guidelines Worki, C. Dupont   +63 more
core   +1 more source

Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts.

Journal of Lipid Research, 1992
Human skin fibroblasts in suspension are able to degrade [1-14C]-labeled alpha- and gamma-methyl branched chain fatty acids such as pristanic and homophytanic acid.
H Singh, M Brogan, D Johnson, A Poulos
doaj   +1 more source