Results 31 to 40 of about 6,573 (255)

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants [PDF]

, 2004
We report the production of two very long chain polyunsaturated fatty acids, arachidonic acid (AA) and eicosapentaenoic acid (EPA), in substantial quantities in a higher plant.
Olga Sayanova, Sayanova, O. V., Mugford, S., Colin M Lazarus, Qi, B., Dobson, G., Lazarus, C. M., Lazarus, CM, Johnathan A Napier, Napier, JA, Stobart, A. K., Mugford, S, Fraser, T., Butler, JL, Gary Dobson, A Keith Stobart, Butler, J., Stobart, AK, Dobson, G, Baoxiu Qi, Tom Fraser, Qi, B, Fraser, TCM, Napier, J. A., Sayanova, OV, Sam Mugford, Justine Butler   +26 more
core   +1 more source

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7 [PDF]

FEBS Letters, 2011
Very long-chain fatty acids (VLCFAs) have a variety of physiological functions and are related to numerous disorders. The key step of VLCFA elongation is catalyzed by members of the elongase family, ELOVLs. Mammals have seven ELOVLs (ELOVL1-7), yet none of them has been purified and analyzed.
Naganuma, Tatsuro, Sato, Yuichiro, Sassa, Takayuki, Ohno, Yusuke, Kihara, Akio   +4 more
openaire   +3 more sources

Biosynthetic mechanism of very long chain polyunsaturated fatty acids in Thraustochytrium sp. 26185[S]

Journal of Lipid Research, 2016
Thraustochytrium, a unicellular marine protist, has been used as a commercial source of very long chain PUFAs (VLCPUFAs) such as DHA (22:6n-3). Our recent work indicates coexistence of a Δ4-desaturation-dependent pathway (aerobic) and a polyketide ...
Dauenpen Meesapyodsuk, Xiao Qiu
doaj   +1 more source

Plasmalogens participate in very-long-chain fatty acid-induced pathology [PDF]

Brain, 2008
Peroxisomes are organelles responsible for multiple metabolic pathways including, the biosynthesis of plasmalogens, a class of phospholipids, and the beta-oxidation of very-long-chain fatty acids (VLCFA). Lack of peroxisomes or dysfunction in any of their normal functions is the cellular basis for human peroxisomal disorders.
Brites, Pedro, Mooyer, Petra A. W., El Mrabet, Leila, Waterham, Hans R., Wanders, Ronald J. A.   +4 more
openaire   +3 more sources

Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. [PDF]

, 2013
BACKGROUND: Intestinal damage and malabsorption caused by chronic environmental enteropathy are associated with growth faltering seen in infants in less-developed countries.
Drammeh, Saikou, Stephen Young, Andrew M Prentice, van der Merwe, Liandré F, Young, Stephen, Fulford, Anthony J, Halliday, Katherine E, Prentice, Andrew M, Saikou Drammeh, Sophie E Moore, Anthony J Fulford, Moore, Sophie E, Liandré F van der Merwe, Katherine E Halliday   +13 more
core   +1 more source

Long-chain omega-3 polyunsaturated fatty acids in relation to gut integrity, growth and cognitive development of rural African children [PDF]

Background and rationale: Weaning foods fed to infants in rural Gambia are often contaminated, resulting in infections which contribute to initiating a persistent inflammation of the gut.
Van der Merwe, Liandre Frances
core   +1 more source

Long-chain and very long-chain polyunsaturated fatty acids in ocular aging and age-related macular degeneration

Journal of Lipid Research, 2010
Retinal long-chain PUFAs (LC-PUFAs, C12-C22) play important roles in normal human retinal function and visual development, and some epidemiological studies of LC-PUFA intake suggest a protective role against the incidence of advanced age-related macular ...
Aihua Liu, James Chang, Yanhua Lin, Zhengqing Shen, Paul S. Bernstein   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.

PLoS Medicine, 2017
BackgroundCombinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated.Methods and findingsWe measured ...
Fumiaki Imamura, Stephen J Sharp, Albert Koulman, Matthias B Schulze, Janine Kröger, Julian L Griffin, José M Huerta, Marcela Guevara, Ivonne Sluijs, Antonio Agudo, Eva Ardanaz, Beverley Balkau, Heiner Boeing, Veronique Chajes, Christina C Dahm, Courtney Dow, Guy Fagherazzi, Edith J M Feskens, Paul W Franks, Diana Gavrila, Marc Gunter, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Tilman Kühn, Olle Melander, Elena Molina-Portillo, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Salvatore Panico, Olov Rolandsson, Sabina Sieri, Carlotta Sacerdote, Nadia Slimani, Annemieke M W Spijkerman, Anne Tjønneland, Rosario Tumino, Yvonne T van der Schouw, Claudia Langenberg, Elio Riboli, Nita G Forouhi, Nick J Wareham   +43 more
doaj   +1 more source

Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. [PDF]

PLoS Pathogens, 2013
Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To
Emre Koyuncu, John G Purdy, Joshua D Rabinowitz, Thomas Shenk   +3 more
doaj   +1 more source