Results 51 to 60 of about 6,573 (255)

A novel ABCD1 G1202A mutation in a Chinese patient with pure adrenomyeloneuropathy and literature review

Genes and Diseases, 2021
Adrenomyeloneuropathy (AMN) is a kind of varied disease caused by ABCD1 gene mutation and characterized by very-long-chain fatty acids (VLCFA) accumulation. It is diagnosed by clinical features, high VLCFAs levels and ABCD1 gene mutation.
Yu Zhang, Guoyong Zhang, Wenhui Chen, Zheng Pu, Lu Song, Xinghua Tang, Zhenguo Liu   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Changes in the Serum Fatty Acid Profile After Anhepatic Phase of Orthotopic Liver Transplantation Procedure

Frontiers in Physiology, 2022
During orthotopic liver transplantation (OLT), the patients’ body remains deprived of this organ for some time, which could cause critical changes in the levels of various metabolites in the circulation, including fatty acids. Thus, the aim of this study
Aleksandra Hliwa, Adriana Mika, Maciej Sledzinski, Dariusz Laski, Bruno Ramos-Molina, Tomasz Sledzinski   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. [PDF]

, 2006
The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline.
Hardy, Pollyanna, Rosemary Knight, Ann Truesdale, Clemens, Felicity, Hardy Pollyanna, Graham E Holder, Vickers Madge, Fletcher, Astrid E, Felicia A Huppert, Elbourne, Diana, Richards, Marcus, Knight, Rosemary, Fletcher Astrid E, Pollyanna Hardy, Madge Vickers, Vickers, Madge, Letley Louise, Letley, Louise, Dangour, Alan D, Felicity Clemens, Dangour Alan D, Ricardo Uauy, Louise Letley, Knight Rosemary, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Uauy Ricardo, Holder, Graham E, Huppert Felicia A, Richards Marcus, Alan D Dangour, Truesdale Ann, Astrid E Fletcher, Marcus Richards, Elbourne Diana, Nicky Fasey, Clemens Felicity, Holder Graham E, Fasey Nicky, Truesdale, Ann, Huppert, Felicia A   +41 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Protein Acylation by Saturated Very Long Chain Fatty Acids and Endocytosis Are Involved in Necroptosis

, 2020
Necroptosis is a form of regulated cell death that is characterized by membrane permeabilization. This permeabilization is responsible for the inflammatory properties of necroptosis and is critical for disease states involving this process. We previously
Daniel, Lu, Jason G., Kay, Ekin, Atilla-Gokcumen, Laura, Parisi, Apoorva, Pradhan, Kiana, Bynum, Jun, Qu, Sherry, Chemler, Viviana, Monje-Galvan, Ilyas, Berhane, Samuel L., Galster, Omer, Gokcumen, Shichen, Shen   +12 more
core   +1 more source

Retinal Sphingolipids and Their Very-Long-Chain Fatty Acid–Containing Species [PDF]

Investigative Opthalmology & Visual Science, 2010
Recent evidence suggests that ceramide metabolism plays an important role in retinal photoreceptor cell survival and apoptosis. The purpose of this study was to characterize sphingolipids in the retina with special emphasis on the very-long-chain-containing saturated (VLC-FA) and polyunsaturated (VLC-PUFA) fatty acid-containing species. The VLC-FAs and
Richard S, Brush, Julie-Thu A, Tran, Kimberly R, Henry, Mark E, McClellan, Michael H, Elliott, Md Nawajes A, Mandal   +5 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation [PDF]

, 2000
We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system.
Scheurink, AJW, Strubbe, JH, Keizer, Klaasjan,, Kuipers, Folkert,, Kuipers, F, Scheurink, Anton J.W.,, Benthem, L, Kuipers, F; id_orcid, Keizer, Klaas-Jan, Wiegman, Coen H.,, Strubbe, Jan H.,, Boer, Sietse F. de,, Steffens, Anton B.,, Steffens, AB, De Boer, SF, Benthem, Lambertus,, Wiegman, CH   +16 more
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