Results 41 to 50 of about 6,573 (255)

Biosynthesis of very long chain fatty acids in Trypanosoma cruzi

Parasitology Research, 2014
Trypanosoma brucei and Trypanosoma cruzi showed similar fatty acid (FA) compositions, having a high proportion of unsaturated FAs, mainly 18:2Δ9,12 (23-39%) and 18:1Δ9 (11-17%). C22 polyunsaturated FAs are in significant amounts only in T. brucei (12-20%) but represent a mere 2% of total FAs in T. cruzi.
Livore, Veronica Ines, Uttaro, Antonio Domingo   +1 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Practical preparation of unsaturated very-long-chain fatty acids (VLCFAs) and very-long-chain alkene pollinator attractants

Scientific Reports
To prepare very-long-chain fatty acids and alkenes (VLCFAs and VLC alkenes) that are known pollinator attractants for sexually deceptive orchids, and biosynthetic precursors thereof, we applied a methodology allowing us to prepare monounsaturated VLCFAs ...
Björn Bohman, Aylin J. Bersch, Gavin R. Flematti, Philipp M. Schlüter   +3 more
doaj   +1 more source

Reassessing very long chain fatty acids elevations: Sitosterolemia as a non-peroxisomal cause

Molecular Genetics and Metabolism Reports
Very-long-chain fatty acids (VLCFAs) are commonly used to diagnose peroxisomal disorders, but elevated levels may also result from other non-peroxisomal causes, leading to diagnostic challenges.
Merve Yoldaş Çelik, Burcu Köşeci, Ezgi Burgaç, Kanay Yararbaş   +3 more
doaj   +1 more source

Very long chain n-3 and n-6 polyunsaturated fatty acids bind strongly to liver fatty acid-binding protein

Journal of Lipid Research, 2002
Synthesis of n-3 and n-6 very long chain-PUFAs (VLC-PUFAs) from 18-carbon essential fatty acids is differentially regulated. The predominant product arising from n-3 fatty acids is docosahexaenoic acid (22:6n-3), with the liver serving as the main site ...
Andrew W. Norris, Arthur A. Spector
doaj   +1 more source

Role of MRI in X-linked adrenoleukodystrophy—A case report

Radiology Case Reports, 2022
X-linked adrenoleukodystrophy is a rare inherited peroxisomal disorder that occurs due to a genetic mutation. This mutation impairs normal transport of very long-chain fatty acids (VLCFAs) into peroxisomes, hence impeding VLCFA breakdown leading to its ...
Sajiva Aryal, MBBS, Suraj Sharma, MBBS, MD, Saroj Poudel, MBBS, Sunita Sharma, MPH   +3 more
doaj   +1 more source

Biosynthesis of very long chain fatty acids by the sciatic nerve of the rabbit [PDF]

FEBS Letters, 1978
The alkanes, a new class of neurolipids, are accumulated in the brain myelin when compared to the other brain subfractions [l--4]. The role of these hydrophobic substances in the myelin formation is far from clear. It appears that alkanes are required for a correct myelination, since the remaining myelin of the Quaking mutant, which bears a defect of ...
Cassagne, Claude, Darriet, Danielle, Bourre, J.M.   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Impact of fatty acid status on immune function of children in low-income countries.

, 2011
In vitro and animal studies point to numerous mechanisms by which fatty acids, especially long-chain polyunsaturated fatty acids (LCPUFA), can modulate the innate and adaptive arms of the immune system.
Liandré van der Merwe, van der Merwe, Liandré, Prentice, Andrew M, Andrew M. Prentice   +3 more
core   +1 more source

Biosynthesis of food constituents: Lipids. 1. Fatty acids and derivated compounds - a review

Czech Journal of Food Sciences, 2006
This review article gives a survey of the principal biosynthetic pathways that lead to the most important common fatty acids and their derivatives occurring in foods and feeds.
Jan Velíšek, Karel Cejpek
doaj   +1 more source