Results 21 to 30 of about 144,497 (249)
Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment
Frontiers in Immunology, 2023 Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though the pathogenesis of IBD remains unclear, diet is increasingly recognized as a pivotal factor influencing its onset and progression. Fatty
Dong Yan +16 more
doaj +1 more source
Journal of Lipid Research, 2011 Elongase of very long chain fatty acids-4 (ELOVL4) is the only mammalian enzyme known to synthesize C28-C36 fatty acids. In humans, ELOVL4 mutations cause Stargardt disease-3 (STGD3), a juvenile dominant macular degeneration. Heterozygous Stgd3 mice that
Anne McMahon +2 more
doaj +1 more source
Membrane Disruption by Very Long Chain Fatty Acids during Necroptosis. [PDF]
ACS Chem Biol, 2019 Necroptosis is a form of regulated cell death which results in loss of plasma membrane integrity, release of intracellular contents, and an associated inflammatory response. We previously found that saturated very long chain fatty acids (VLCFAs), which contain ≥20 carbons, accumulate during necroptosis.
Parisi LR +8 more
europepmc +4 more sources
Journal of Lipid Research, 1994 A new family of alpha,omega-dicarboxylic, very long chain fatty acids was isolated and characterized from the lipids of thermophilic anaerobic eubacterium, Thermoanaerobacter ethanolicus 39E. After the isolation of the membrane, the fatty acyl components
S Jung, J G Zeikus, R I Hollingsworth
doaj +1 more source
The Very-Long-Chain Fatty Acid Synthase Is Inhibited by Chloroacetamides
Zeitschrift für Naturforschung C, 2004 Abstract The first elongation step to form very-long-chain fatty acids (VLCFAs) is catalyzed by the VLCFA-synthase. CoA-activated fatty acids react with malonyl-CoA to condense a C2-unit. As shown with recombinant enzyme this reaction is specifically inhibited by chloroacetamide herbicides. The inhibition is alleviated when the inhibitor
Thomas, Götz, Peter, Böger
openaire +2 more sources
How very-long-chain fatty acids could signal stressful conditions in plants?
Frontiers in Plant Science, 2016 Although encountered in minor amounts in plant cells, very-long-chain fatty acids exert crucial functions in developmental processes. When their levels is perturbed by means of genetic approaches, marked phenotypic consequences that range from severe ...
Antoine de Bigault du Granrut +2 more
doaj +1 more source
Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency: Family Impact and Perspectives
International Journal of Neonatal Screening, 2023 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD) is a fatty acid oxidation disorder characterized by the decreased ability of the enzyme very-long-chain acyl-CoA dehydrogenase to break down fatty acids with 14 to 20-long carbon chains.
Sarah Crawford +5 more
doaj +1 more source
Very long-chain saturated fatty acids and diabetes and cardiovascular disease
Current Opinion in Lipidology, 2021 Purpose of review In contrast to other saturated fatty acids, very long-chain saturated fatty acids (VLSFAs) have received limited attention The purpose of this review is to summarize the associations of VLSFAs, including arachidic acid, behenic acid, and lignoceric acid, with cardiovascular disease outcomes and type 2 diabetes;
Lemaitre, Rozenn N., King, Irena B.
openaire +3 more sources
Distribution of molecular species of sphingomyelins in different parts of bovine digestive tract
Journal of Lipid Research, 1975 Sphingomyelins were isolated from mucosal layers of bovine rennet stomach, duodenum, jejunoileum, and colon ascendens. The ceramides obtained after phospholipase degradation were characterized by thin-layer chromatography, mass spectrometry, and gas ...
M.E. Breimer
doaj +1 more source
Role of long-chain and very-long-chain polyunsaturated fatty acids in macular degenerations and dystrophies [PDF]
Clinical Lipidology, 2011 Macular degeneration is a progressive, bilateral eye disorder that damages the macula of the human eye. The most common form of macular degeneration is age-related macular degeneration (AMD), which is the leading cause of irreversible blindness in people older than 50 years in developed countries.
Aihua, Liu +4 more
openaire +2 more sources