Results 51 to 60 of about 559 (125)

Effects of inhibition of Janus kinase signalling during controlled mechanical ventilation on the rate of skeletal muscle protein synthesis

The Journal of Physiology, Volume 603, Issue 22, Page 7029-7047, November 15, 2025.
Abstract figure legend 2H2O labelling was used to examine muscle protein fractional synthesis rates (FSR) in an intensive care unit (ICU) model and non‐anaesthetized control rats, and to compare the effects of a Janus kinase (JAK)/STAT inhibitor on protein FSR in the ICU model.
William J. Evans, Mahalakshmi Shankaran, Lars Larsson, Nicola Cacciani, Yvette Hedström, James L. Kirkland, Tamar Tchkonia, Hussein Mohammed, Tyler Field, Marc K. Hellerstein   +9 more
wiley   +1 more source

Transcriptome profiling of the diaphragm in a controlled mechanical ventilation model reveals key genes involved in ventilator-induced diaphragmatic dysfunction

BMC Genomics, 2021
Background Ventilator-induced diaphragmatic dysfunction (VIDD) is associated with weaning difficulties, intensive care unit hospitalization (ICU), infant mortality, and poor long-term clinical outcomes.
Ruining Liu, Gang Li, Haoli Ma, Xianlong Zhou, Pengcheng Wang, Yan Zhao   +5 more
doaj   +1 more source

Role of the Chest Wall in Newborn Respiratory Function at Birth

The FASEB Journal, Volume 39, Issue 19, 15 October 2025.
At birth, liquid is cleared from the airways into lung tissue during lung aeration, causing the lungs to swell, which in turn causes the chest wall to expand. As the newborn chest wall is highly compliant, it can easily expand, but its high compliance reduces breathing efficiency after birth.
C. Diedericks, K. J. Crossley, I. M. Davies, D. A. Blank, S. J. E. Cramer, M. J. Wallace, A. B. te Pas, M. J. Kitchen, S. B. Hooper   +8 more
wiley   +1 more source

Temporary transvenous diaphragm pacing vs. standard of care for weaning from mechanical ventilation: study protocol for a randomized trial

Trials, 2019
Background Mechanical ventilation (MV) is a life-saving technology that restores or assists breathing. Like any treatment, MV has side effects. In some patients it can cause diaphragmatic atrophy, injury, and dysfunction (ventilator-induced diaphragmatic
Douglas Evans, Deborah Shure, Linda Clark, Gerard J. Criner, Martin Dres, Marcelo Gama de Abreu, Franco Laghi, David McDonagh, Basil Petrof, Teresa Nelson, Thomas Similowski   +10 more
doaj   +1 more source

Oxygen administration for patients with ARDS

Journal of Intensive Care, 2021
Acute respiratory distress syndrome (ARDS) is a fatal condition with insufficiently clarified etiology. Supportive care for severe hypoxemia remains the mainstay of essential interventions for ARDS.
Shinichiro Ohshimo
doaj   +1 more source

Functional state of the diaphragm in patients with cervical spinal cord injury at the stages of respiratory support

Хирургия позвоночника, 2022
Objective. To analyze the role of the functional state of the diaphragm in patients with cervical spinal cord injury at the stages of respiratory support and to substantiate additional criteria for their readiness to transfer to spontaneous breathing ...
Ivan A. Statsenko, Maya N. Lebedeva, Aleksey V. Palmash   +2 more
doaj   +1 more source

Construction and validation of a risk prediction model for early ventilator-induced diaphragm dysfunction in mechanically ventilated patients

Frontiers in Medicine
BackgroundMechanical ventilation is a core life-support technique in intensive care units (ICUs), but it can easily induce ventilator-induced diaphragm dysfunction (VIDD) in the early stage of mechanical ventilation (within 24 h).
Min-Qing Long, Yu-Ting Liu
doaj   +1 more source

Pengaruh Pemberian Aminofilin pada Pasien dengan Difficult Weaning Ventilator Mekanik Pascaevantrasio Diafragma

Jurnal Anestesi Perioperatif, 2023
Penggunaan ventilasi mekanik dapat mengakibatkan kelemahan diafragma yang didiagnosis sebagai ventilator induced diaphragmatic injury (VIDD) yang dapat terjadi mulai 72 jam pascapenggunaan ventilator mekanik.
Franz Josef Tarigan, Erwin Pradian
doaj   +1 more source

Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice

Physiological Reports, Volume 13, Issue 7, April 2025.
Abstract Dual inhibition of sodium glucose cotransporters 1 and 2 (SGLT1/SGLT2) by sotagliflozin protects the kidney and heart in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). To gain mechanistic insights, the current study aimed to establish a murine model of hypertensive CKD that shows cardio‐renal protection by ...
Helen Goodluck, Alice Zemljic‐Harpf, Ony Araujo Galdino, Sadhana Kanoo, Natalia Lopez, Young Chul Kim, Volker Vallon   +6 more
wiley   +1 more source

Chaperone Proteins: The Rising Players in Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Despite significant progress in understanding the molecular aetiology of muscle atrophy, there is still a great need for new targets and drugs capable of counteracting muscle wasting. The role of an impaired proteostasis as the underlying causal mechanism of muscle atrophy is a well‐established concept. From the earliest work on muscle atrophy
Davide Acquarone, Alessandro Bertero, Mara Brancaccio, Matteo Sorge   +3 more
wiley   +1 more source