Results 11 to 20 of about 900,097 (207)

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment. [PDF]

Cancers (Basel), 2020
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of structurally related proteins showing distinct expression patterns in
Strouhalova K, Přechová M, Gandalovičová A, Brábek J, Gregor M, Rosel D.   +5 more
europepmc   +5 more sources

Intermediate filaments: Vimentin moves in [PDF]

Current Biology, 2002
Vimentin intermediate filaments move bi-directionally along microtubules in the cell. Recent work has identified the microtubule motor cytoplasmic dynein as the missing inward-directed motor that drives this ...
Clarke, Emma J., Clarke, Emma J, Allan, Viki   +2 more
core   +5 more sources

Post-translational modifications soften vimentin intermediate filaments [PDF]

Nanoscale, 2021
The mechanical properties of biological cells are determined by the cytoskeleton, a composite biopolymer network consisting of microtubules, actin filaments and intermediate filaments (IFs). By differential expression of cytoskeletal proteins, modulation
Denz, Manuela, Menzel, Julia, Kraxner, J., Denz, M., Kraxner, Julia, Urlaub, Henning, Parfentev, I., Urlaub, H., Lorenz, Charlotta, Parfentev, Iwan, Menzel, J., Köster, Sarah, Lorenz, C., Schwappach, B., Schwappach, Blanche, Silbern, I., Silbern, Ivan, Köster, S.   +17 more
core   +7 more sources

The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2014
Abstract There is an accumulation of evidence in the literature demonstrating the integral role of vimentin intermediate filaments (IFs) in the progression of lung cancers. Vimentin IF proteins have been implicated in many aspects of cancer initiation and progression, including tumorigenesis, epithelial-to-mesenchymal transition (EMT),
Karen Ridge, Dale Shumaker
exaly   +5 more sources

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers [PDF]

Cell Reports, 2015
The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive.
Yaming Jiu, Jaakko Lehtimäki, Sari Tojkander, Fang Cheng, Harri Jäälinoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen   +8 more
doaj   +2 more sources

Nanomechanical studies of vimentin intermediate filaments

, 2012
Intermediate filaments, microtubules and microfilaments are the major components of the cytoskeleton. Though it is known that intermediate filaments play an important role in the mechanical behaviour of cells, it is surprising that their mechanical ...
Wong, Kai-lun., 黃棨麟.
core   +3 more sources

Vimentin intermediate filaments modulate the motility of mitochondria

Molecular Biology of the Cell, 2011
Interactions with vimentin intermediate filaments (VimIFs) affect the motility, distribution, and anchorage of mitochondria. In cells lacking VimIFs or in which VimIF organization is disrupted, the motility of mitochondria is increased relative to ...
Ivan S. Chernoivanenko, Melissa G. Mendez, Alexander A. Minin, Pyotr A. Tyurin-Kuzmin, Vladimir I. Gelfand, Oxana E. Nekrasova, Robert D. Goldman, Edward R. Kuczmarski   +7 more
core   +3 more sources

Stress-Strain Behavior of Single Vimentin Intermediate Filaments [PDF]

, 2018
Cells are the basic unit of living organisms and consist of a cytoplasm, which is enclosed by a membrane. As building blocks of life with a plethora of functions, cells have to be equipped with a high degree of mechanical resistance, durability, and ...
Johanna Lena Block, Block, Johanna Lena
core   +5 more sources

Intermediate Filaments in Breast Cancer Progression, and Potential Biomarker for Cancer Therapy: A Narrative Review [PDF]

Breast Cancer: Targets and Therapy
Widad Aghnia Shalannandia,1 Yoan Chou,2 Muhammad Hasan Bashari,1,3 Astrid Feinisa Khairani1,3 1Graduate School of Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Jatinangor, West Java, Indonesia; 2Graduate ...
Shalannandia WA, Chou Y, Bashari MH, Khairani AF   +3 more
doaj   +1 more source

Geometric control of vimentin intermediate filaments. [PDF]

Biomaterials, 2014
Significant efforts have addressed the role of vimentin intermediate filaments (VIF) in cell motility, shape, adhesion and their connections to microfilaments (MF) and microtubules (MT). The present work uses micropatterned substrates to control the shapes of mouse fibroblasts and demonstrates that the cytoskeletal elements are dependent on each other ...
Shabbir SH, Cleland MM, Goldman RD, Mrksich M.   +3 more
europepmc   +4 more sources