Hierarchical Structure Controls Nanomechanical Properties of Vimentin Intermediate Filaments [PDF]
Intermediate filaments (often abbreviated as IFs), in addition to microtubules and microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells (Figure 1).
Markus J. Buehler, Je´re´mie Bertaud
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Background The VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity.
Roy Polly +2 more
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Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength [PDF]
By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation of a supercellular scaffold that imparts mechanical strength to a tissue.
Godsel, Lisa M. +35 more
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Mitochondrial membrane potential is regulated by vimentin intermediate filaments.
This study demonstrates that the association of mitochondria with vimentin intermediate filaments (VIFs) measurably increases their membrane potential. This increase is detected by quantitatively comparing the fluorescence intensity of mitochondria stained with the membrane potential‐sensitive dye tetramethylrhodamine‐ethyl ester ...
Chernoivanenko IS +4 more
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Systemic Nanomechanical Single-Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation. [PDF]
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Ku M, Kwon J, Yoon N, Byeon HK, Yang J.
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Cell cultures of human ciliary muscle: growth, ultrastructural and immunocytochemical characteristics [PDF]
Primary ciliary muscle cell cultures derived from human donors (16-91 years) were established and characterized by comparing them with ciliary muscle in tissue sections using immunocytochemical and ultrastructural methods.
Baur, A. +3 more
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Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1
In this study we show that binding of mitochondria to vimentin intermediate filaments (VIF) is regulated by GTPase Rac1. The activation of Rac1 leads to a redoubling of mitochondrial motility in murine fibroblasts.
Elena A. Matveeva +3 more
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Identification of Vimentin as a Potential Therapeutic Target against HIV Infection
A combination of antiviral drugs known as antiretroviral therapy (ART) has shown effectiveness against the human immunodeficiency virus (HIV). ART has markedly decreased mortality and morbidity among HIV-infected patients, having even reduced HIV ...
Celia Fernández-Ortega +16 more
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The Diversity of Intermediate Filaments in Astrocytes
Despite the remarkable complexity of the individual neuron and of neuronal circuits, it has been clear for quite a while that, in order to understand the functioning of the brain, the contribution of other cell types in the brain have to be accounted for.
Maja Potokar +3 more
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Follikulogenese und Intermediärfilamente [PDF]
Trotz intensiver Forschung sind viele Details der Oogenese und Follikuologenese des Rindes erst wenig verstanden. So ist nicht klar, wie es zur gezielten Aktivierung einer bestimmten Zahl von Primordialfollikel pro Zyklus kommt. Sicher ist aber, dass die
Wendl, Josef Reinhard Werner Erik
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