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Cell Research, 2020 A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic.
Chunlong Ma +10 more
semanticscholar +1 more source
Cytoplasmic Viral Replication Complexes [PDF]
Cell Host & Microbe, 2010 Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication efficiency and protection from host defenses. In particular, recent studies with diverse positive-strand RNA viruses have further elucidated the ultrastructure of membrane-bound RNA replication ...
Arturo Diaz +2 more
openaire +3 more sources
Autophagy in Viral Replication and Pathogenesis [PDF]
Molecules and Cells, 2010 Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived proteins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pathogens. A growing list of viruses has been shown to affect this cellular pathway.
Jing-hsiung James Ou, Donna Sir
openaire +3 more sources
Cyclophilins as Modulators of Viral Replication [PDF]
Viruses, 2013 Cyclophilins are peptidyl‐prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined.
Stephen D. Frausto +2 more
openaire +4 more sources
Chinese Giant Salamander Iridovirus 025L Is a Viral Essential Gene
Viruses, 2023 Ranavirus is a large nucleocytoplasmic DNA virus. Chinese giant salamander iridovirus (CGSIV) belongs to the ranavirus genus, and its replication involves a series of essential viral genes.
Zijing Liu +7 more
doaj +1 more source
Microtubules in viral replication and transport [PDF]
The Plant Journal, 2013 SummaryViruses use and subvert host cell mechanisms to support their replication and spread between cells, tissues and organisms. Microtubules and associated motor proteins play important roles in these processes in animal systems, and may also play a role in plants.
Eduardo José Peña +4 more
openaire +5 more sources
Special Issue: “Viral Replication Complexes” [PDF]
Viruses, 2021 Viruses are extraordinary biological entities that can only thrive as obligate intracellular parasites, exploiting other living cellular components in order to reproduce [...]
Núria Verdaguer, Diego S. Ferrero
openaire +5 more sources
A joint Bayesian hierarchical model for estimating SARS-CoV-2 diagnostic and subgenomic RNA viral dynamics and seroconversion [PDF]
, 2023 Understanding the viral dynamics and immunizing antibodies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for devising better therapeutic and prevention strategies for COVID-19. Here, we present a Bayesian hierarchical model that jointly estimates the diagnostic RNA viral load reflecting genomic materials of SARS-CoV-2 ...
arxiv +1 more source
Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution
mBio, 2020 HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen +7 more
doaj +1 more source
Capping pores of alphavirus nsP1 gate membranous viral replication factories
Nature, 2020 Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and alphaviruses, carry out transcription and replication inside virus-induced membranous organelles within host cells 1 – 7 .
Rhian Jones +3 more
semanticscholar +1 more source