Results 31 to 40 of about 2,128,088 (408)
Structural Insights into APOBEC3-Mediated Lentiviral Restriction
Viruses, 2020 Mammals have developed clever adaptive and innate immune defense mechanisms to protect against invading bacterial and viral pathogens. Human innate immunity is continuously evolving to expand the repertoire of restriction factors and one such family of ...
Krista A. Delviks-Frankenberry +2 more
doaj +1 more source
Journal of Virology, 2020 The outbreak of SARS-CoV-2, the cause of COVID-19, is ongoing. New and effective antiviral agents that combat the disease are needed urgently. Here, we found that an inhaled corticosteroid, ciclesonide, suppresses the replication of coronaviruses ...
S. Matsuyama +7 more
semanticscholar +1 more source
Microbiology Spectrum, 2021 Picornaviruses are a diverse and major cause of human disease, and their genomes replicate with intracellular membranes. The functionality of these replication organelles depends on the activities of both viral nonstructural proteins and co-opted host ...
Jia-Ying Lu +6 more
doaj +1 more source
Analysis of the Replication Mechanisms of the Human Papillomavirus Genomes
Frontiers in Microbiology, 2021 The life-cycle of human papillomaviruses (HPVs) includes three distinct phases of the viral genome replication. First, the viral genome is amplified in the infected cells, and this amplification is often accompanied by the oligomerization of the viral ...
Lisett Liblekas +7 more
doaj +1 more source
Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments [PDF]
, 2009 Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV ...
Ahmed +25 more
core +2 more sources
Viruses, 2020 Recent discoveries on virus-driven hijacking and compartmentalization of the cellular glycolytic and fermentation pathways to support robust virus replication put the spotlight on the energy requirement of viral processes.
P. D. Nagy, Wenwu Lin
semanticscholar +1 more source
The human papillomavirus 16 E2 protein is stabilised in S phase [PDF]
, 2009 The human papillomavirus 16 E2 protein regulates transcription from, and replication of, the viral genome and is also required for segregation of the viral genome via interaction with mitotic bodies.
Dornan, E.S. +3 more
core +1 more source
mBio, 2022 The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in ...
Ryan C. Burdick +5 more
doaj +1 more source
Nuclear actin and myosins in adenovirus infection [PDF]
, 2015 Adenovirus serotypes have been shown to cause drastic changes in nuclear organization, including the transcription machinery, during infection. This ability of adenovirus to subvert transcription in the host cell facilitates viral replication.
De Lanerolle, Primal +2 more
core +1 more source
The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15
bioRxiv, 2020 Steroid compounds, which are expected to have dual functions in blocking host inflammation and MERS-CoV replication, were screened from a chemical library.
S. Matsuyama +7 more
semanticscholar +1 more source