FUSE binding protein FUBP3 is a potent regulator in Japanese encephalitis virus infection
Virology Journal, 2021 Background The JEV genome is a positive-sense RNA with a highly structured capped 5′UTR, 3′UTR and a large open reading frame. 3′UTR is the untranslated region of flavivirus and has various important functions during viral replication, such as ...
Peng Xu, Wei Tong, Young-Mao Chen
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Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART [PDF]
Bulletin of Mathematical Biology (67) 1227-1251 (2005), 2004 When highly active antiretroviral therapy is administered for long periods of time to HIV-1 infected patients, most patients achieve viral loads that are ``undetectable'' by standard assay (i.e., HIV-1 RNA $ < 50$ copies/ml). Yet despite exhibiting sustained viral loads below the level of detection, a number of these patients experience unexplained ...
arxiv +1 more source
Viral quasispecies profiles as the result of the interplay of competition and cooperation [PDF]
BMC Evolutionary Biology 2010 10:137, 2010 Viral quasispecies can be regarded as a swarm of genetically related mutants or a quasispecies (QS). A common formalism to approach QS is the replicator-mutator equation (RME). However, a problem with the RME is how to quantify the interaction coefficients between viral variants.
arxiv +1 more source
HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors
Viruses, 2021 DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription.
Jessica E. Packard, Jill A. Dembowski
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Selection strategies for randomly partitioned genetic replicators [PDF]
Phys. Rev. E 99, 062416 (2019), 2017 The amplification cycle of many replicators (natural or artificial) involves the usage of a host compartment, inside of which the replicator express phenotypic compounds necessary to carry out its genetic replication. For example, viruses infect cells, where they express their own proteins and replicate.
arxiv +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication. [PDF]
PLoS ONE, 2016 Reovirus replication and assembly occurs within viral inclusion bodies that formed in specific intracellular compartments of cytoplasm in infected cells.
Jie Zhang +4 more
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Viral replication dynamics could critically modulate vaccine effectiveness and should be accounted for when assessing new SARS-CoV-2 variants [PDF]
arXiv, 2021 In this article, we propose a theory to explain the reduction in vaccine effectiveness (VE) against the Delta SARS-CoV-2 variant and decreasing VE over time reported in recent studies. Using a model illustration, we show that in-host viral replication dynamics and delays in immune response could play a key role in VE.
arxiv
Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies
Molecular Oncology, EarlyView.Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren +16 more
wiley +1 more source
mBioHIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in
Saiful Islam +7 more
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